Protein Alignment eIF4G1 and eif4g2b

DIOPT Version :9

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: NP_001013461.2
• Gene: eif4g2b / 334618
• ZFINID: ZDB-GENE-030131-6550
• Length: 898
• Species: Danio rerio
• Alignment Length: 1053
• Identity: 242/1053 - (22%)
• Similarity: 410/1053 - (38%)
• Gaps: 276/1053 - (26%)

  Fly   950 GGGRSSMKGMIHVNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEK---DELVRRVRGILN 1011
            ||||.:.:   |...::.....|.:.......|.:.......|..|:.||   |.:.|:||||||
Zfish    20 GGGRGASQ---HYPKTVGNSEYLGKTPGPSVQRWVPSRSTRRDVNSSTEKEHHDAIFRKVRGILN 81

  Fly  1012 KLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVID---E 1073
            |||||:||.|..|::.:.:|:...:..:|:|:.:||::||.:|..||:||.|||.:....|   .
Zfish    82 KLTPEKFDKLCLELLNVGVDSKLVLKGIILLIVDKALEEPKYSSLYAQLCLRLAEDAPNFDGPTP 146

  Fly  1074 RMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEE 1138
            .::|..| .|..||..|:.|.:.||..........:|:..|:..:                 |||
Zfish   147 EIQSSQK-QSTTFRRLLITKLQDEFENRTKNVDLYDKQDNPLTSE-----------------EEE 193

  Fly  1139 ERKIRR-RSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHS----EDM---LECLCKLLTTVGA 1195
            :|.|.: :..|.::|||||.|:.::...|::.||.|||....    :||   |||||:::.|||.
Zfish   194 QRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMGEDLECLCQIMRTVGP 258

  Fly  1196 KFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFMLQDVIDLRKNKWQTSR--- 1257
            :.:.....|       .:::...|||::.:..|     :.:|:||:|||.::||:|.|...:
Zfish   259 RLDHEKAKS-------LMDQYFGRMQSLMNNKD-----LPARIRFLLQDTVELRENNWVPRKAFI 311

  Fly  1258 NEAPKTMGQIEKEA----------KNEQLSAQYF-----------------GTLS---STTPGGS 1292
            :..|||:.||.::|          .|:.:...:|                 |.|:   ...||..
Zfish   312 DNGPKTINQIRQDAVKDLGVFIPPMNQGMRMDFFLEGPFMPNRMKLDRETLGGLADMFGQMPGSG 376

  Fly  1293 QG-GSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGHSNGNNDENT 1356
            .| |.|...||.:...|..|::..:         ||::..|.|:.....:......:.|.|..
Zfish   377 IGTGPGVIQDRFSPTLGRHRTNPLF---------NGHMASQPQSQFDLGMKPFMKSNQGQNQH-- 430

  Fly  1357 WHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQFIWISSDTTRLSSAPTPTPSNPFAV 1421
            :|.|..                :.|:.|..::|.|
Zfish   431 FHNQNQ----------------NHLNQQQAQSKDM------------------------------ 449

  Fly  1422 LSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLL 1486
                             .||    :.||.|..|.    :..|...|....:|...:...|..|::
Zfish   450 -----------------PPR----FKKGQMNADE----ISLRPAQSFLLNKNQVPKLQPQIPTMI 489

  Fly  1487 SSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVF 1551
            ..|.|...:      |.||.....:.       .:.|.|.....:.|      :||:...|
Zfish   490 PPSAQPPRT------QTPPLGQPPQL-------GLKTNPPLIQEKPQ------KTTKKPPP---- 531

  Fly  1552 IEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIKR----VPEKLR----CSFIYYILTDYLH 1608
              |.|..||:.:::|:|.  |:..:.||....|..:|.    :||.|.    ||.   ..||
Zfish   532 --AREELLKMTENIVTEY--LNNRNMEVAVSGVREMKAPKHFLPEMLSKIILCSL---ERTD--- 586

  Fly  1609 LANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVK 1673
                  :.|...|..::.|..:.:|:.:|...|..........:.||||.:..|:.|||...::.
Zfish   587 ------EDREQASTLINTLRTEGFITGEHFMQALLNVLDQCPKIEVDIPLVKSYLAQFAARAVIA 645

  Fly  1674 KILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMWI-------KFNLKWSDFMP 1731
            :::::::|.:       |......|  ...:.|.|:......|. |:       |.|::  ..:|
Zfish   646 ELVSVAELAH-------PLENGNHF--PLFLLCLQQASKLKDRE-WLTDLFQQSKVNMQ--KMLP 698

  Fly  1732 ESEVADFIKFNRLEYVENESKS---PVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNGN 1793
            |   .|..|...||.:|.:..|   |::       |..|.::..|    |...:...|..:...|
Zfish   699 E---IDQNKDRMLEVLEGKGLSFLFPLL-------KLEKELLKQI----KADPSPQTIYKWIKDN 749

  Fly  1794 I---MVVDKLFIR--------------GLTETLSNFSIHYKDNSYKLESE-----TFQKFCIPVL 1836
            |   :.:||.||.              |:.|.....|...|:   :|:.|     :|:    ||:
Zfish   750 ISPKLHIDKGFINILVTSFLQYIFAELGVPECDEQLSFPSKE---QLDQEKQLLHSFK----PVM 807

  Fly  1837 QRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWR-DSKDQSAGKG 1900
            |:::..:.:.|:..||.||:..:....|:|:|.......||..:|::|:...|: |...:..|||
Zfish   808 QKFLHEHTNLQVSALYALQVHCNANAFPKGMLLRYFVHFYDMEIIEEEAFLAWKEDISQEFPGKG 872

  Fly  1901 VAVKSLNPFFNSL 1913
            .|:..:|.:...|
Zfish   873 KALFQVNQWLTWL 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	84/258 (33%)
		MA3	1562..1677	CDD:280933	28/122 (23%)
		W2_eIF4G1_like	1764..1895	CDD:211397	35/153 (23%)
eif4g2b	NP_001013461.2	MIF4G	73..303	CDD:280935	84/259 (32%)
		MA3	536..649	CDD:214714	30/126 (24%)
		W2_eIF4G1_like	732..867	CDD:211397	33/145 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920