Protein Alignment eIF4G1 and Eif4g3

DIOPT Version :10

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: XP_038965571.1
• Gene: Eif4g3 / 298573
• RGDID: 1311370
• Length: 1807
• Species: Rattus norvegicus
• Alignment Length: 2060
• Identity: 482/2060 - (23%)
• Similarity: 767/2060 - (37%)
• Gaps: 587/2060 - (28%)

  Fly    17 AMQPH-SAQNMILPANKKTKKYDQQVPTSKPQSLHQPLQPQHSHPTAQPQFQINKAYNVVSILKA 80
            |..|| :.:.:..||       .||:|....|   |||:.:...||      ::..|:.|:
  Rat    57 AAPPHPNIRALQTPA-------PQQIPRGPVQ---QPLEDRIFPPT------VSAVYSTVT---- 101

  Fly    81 SAQIAQQ---------SPHLTNQQHP-----PIHHPQQTQQHQQSYTNVVNRSLSASEPVRAQSS 131
              |:|:|         |.|..|:.||     |..|.......|..|.:..|          |..:
  Rat   102 --QVARQPGPPTPSPYSAHEINKGHPNLAATPPGHASSPGLSQTPYPSGQN----------AGPA 154

  Fly   132 VICNGSSILTVNSR-QLNSGDMNSTAIY------------NISSYRKLTGSLDGNVCFLNVQDIK 183
            .:....:..|:||: |..|....:..::            ....||.|.|......|
  Rat   155 TLVYPQAPQTMNSQPQARSPPSRAVPVHCPDNWKRRKVLEQTPVYRSLAGRGWIKYC-------- 211

  Fly   184 QNGNISGSVVSNKSIVGVGSEKSSCTG------VSINNQIVLPNAQIGTSMGI----AGTTTAGT 238
                          |...|...:...|      .....||..|.|.|..|...    |.|.||
  Rat   212 --------------IFAAGPRPAHHQGGFRPIQFFQRPQIQPPRAAIPNSSPSLRPGAQTPTA-- 260

  Fly   239 SYMHEKNIVGVSVNCVNTSKKYDFNNSSLLSNN---SYPASTAEYVSTGNNNSGNTRSNPQ---S 297
                                .|..|...::.|:   .||..           .|.....||   |
  Rat   261 --------------------VYQANQHIMMVNHLPMPYPVP-----------QGPQYCIPQYRHS 294

  Fly   298 GGIFRGPPST-PNAPRGASGGATRHVHVQPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAPA 361
            |..:.|||.. |..|.|..          |.|..|...:......|.:.|.|..       |..|
  Rat   295 GPPYVGPPQQYPVQPPGPG----------PFYPGPGPGDFANAYGTPFYPSQPV-------YQSA 342

  Fly   362 PMPYYQYQYVPTLQQQPPHTRSAVTVN-TNVNVGNN--LQPVQSG-----PNGPLPVPGASSSQI 418
            |:      .|||.||.||..|...|:. .:.|.|..  .:.:.||     |..|:..|.::.:..
  Rat   343 PI------IVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPP 401

  Fly   419 QLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVGVMTTSVQ-----PQPVQVQPASRRRHQHR 478
            |.|.|.....:..|.|      |:....:.....|...:...|     |.||...|::      .
  Rat   402 QQLPSQAPEHSPVVYG------TVESAHLAASTPVTAASDQKQEEKPKPDPVFQSPST------V 454

  Fly   479 LQIIDPTTKKNILDDFDKTKSNTDNEFSDQVTSTNTPATVLSEGPIRIPQQESVGLNN---LTST 540
            |:::....||.......:|.:   .|.|.:...|::|.|:.......:|...|..|::   ||:.
  Rat   455 LRLVLSGEKKEQAGQIPETAA---GEPSPEPPRTSSPTTLPPLARSSLPSPMSAALSSQQLLTAE 516

  Fly   541 SS-QGSESRTNAPYIPIETTPISRTDVGPTPIVSAMTD-----------AP------SVEILPTP 587
            .. :.|.|:.:||  |:. :|.|.| ..|.|   ::||           ||      |..:|...
  Rat   517 DKCELSSSKDDAP--PVR-SPTSCT-AAPGP---SLTDDIGLCKKPCGVAPPDGQLVSSPVLINE 574

  Fly   588 QRGRSKKIPIVSPKNVSESI---VAPITDETD-----------DAGSTPISRATEESMPPNQTHP 638
            ..|..:|:|  :.:|..:.:   |.|:|.|.:           :...|||:.:|..|..|....|
  Rat   575 MNGVGEKLP--AKENTVDMVRQEVLPLTLELEILEHPQEERKVECTPTPITPSTMPSFSPAPPTP 637

  Fly   639 -------NLLISDSSKHKQAVS-------------NSEISKDAPTGLKE-MHVAELESSVASENH 682
                   .:::|.:.....||:             .:.:||||    || ...||.||...:|.
  Rat   638 PASPPCTPVVLSATIARSPAVATVIQRVVDEGESLRTCLSKDA----KETQDKAEAESDGQTEE- 697

  Fly   683 PAGILDVNVNKSSQSLDFSADPEIDSIGAISPTSPNAVSPILHEVLDNTELSKKLENSTTERFKD 747
                              :|||:    .|.:..||   :|:     .....:.|....|.||.:.
  Rat   698 ------------------TADPQ----NAHAGRSP---APV-----QTATTAPKTWKKTKERTRT 732

  Fly   748 SQSV-----EKPTHQELSLRNATD-ETEISAMALQ---DVNSLDNNQIEKTYPSKPKLNVDVSED 803
            ...|     |....:|||:.:..: |.|..:...|   |.::|...:.|:.       |.:.:|.
  Rat   733 PDEVLEAEAEPKAEEELSVDSVLEPEQEKMSQGFQFERDPSTLKRAKAEEE-------NGEEAEP 790

  Fly   804 I-SSRESAIK---------STSTKNTGVDVGLQSDSKPETTLNDKQDSTDLKVKVSAKISSIINY 858
            : :..|||.:         ||.:...||....:::|
  Rat   791 VRNGAESASEGEGGDANSGSTDSSGDGVTFPFKAES----------------------------- 826

  Fly   859 NEGQWSPNNPSGKKQYDREQLLQLREVKASRIQPE----VKNV-----------------SILPQ 902
                |.|.:..||||||||.||.::.:.|...:||    :.:|                 .|||:
  Rat   827 ----WKPADTEGKKQYDREFLLDIQFMPACIQKPEGLPPISDVVLDKINQPRLPMRTLDPRILPR 887

  Fly   903 -PNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGMIH----- 961
             |:..|:|                 .:...::.|   |:.:.:..|   |.|.|..|...
  Rat   888 GPDFTPAF-----------------ADFGRQTPG---GRGVPLLSV---GPRRSQPGQRREPRKI 929

  Fly   962 VNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEII 1026
            :.:|:.:||.|.:.||||:|.  .|.|..:|...:::..||.|:||.|||||||:.|:.|::::.
  Rat   930 ITVSVKEDVHLRKAENAWKPS--QKRDSHADDPESIKTQELFRKVRSILNKLTPQMFNQLMKQVS 992

  Fly  1027 KLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAA-EVKVIDERMESETKSNSAHFRNAL 1090
            .|.:||.:::..||.||||||||||:|||:||.:|:.|.. :|.:.|:      ..|:.:||..|
  Rat   993 ALTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADK------PGNTVNFRKLL 1051

  Fly  1091 LDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGE 1155
            |::.::||.::.:.....|||.:    :::..:...|:..|...|||.:.|.||||.|.::||||
  Rat  1052 LNRCQKEFEKDKADDDVFEKKQK----ELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGE 1112

  Fly  1156 LFKISMLTGKIIYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRM 1220
            |||:.|||..|::.|:..||..|.|:.|||||:||||:|          ||    ...||:..||
  Rat  1113 LFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIG----------KD----LDFEKAKPRM 1163

  Fly  1221 QAIASKTDK--DGARVSSRVRFMLQDVIDLRKNKWQTSR-NEAPKTMGQIEKEAK----NEQLSA 1278
            ....::.:|  ...:.|||:|||||||||||...|.:.| ::.|||:.||.||||    .||...
  Rat  1164 DQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKV 1228

  Fly  1279 QYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNV-- 1341
            |...|.....|             |..|..|...::..|..:|:..|........:..:...:
  Rat  1229 QQLMTKEKRRP-------------GVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQL 1280

  Fly  1342 -------SGGAGHSNGNNDENTWHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQFIW 1399
                   |.|.|.|.|           :|.|.:.|:.|:
  Rat  1281 VPKAQLGSWGKGSSGG-----------AKASETDALRSS-------------------------- 1308

  Fly  1400 ISSDTTRLSSAPTPTPS-NPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSR 1463
             :|...|.|....|.|| :|.|   :.:|.:|           .:...::|||.|::.|:.:.:.
  Rat  1309 -ASSLNRFSPLQPPAPSGSPSA---TPLDFDS-----------RRALTSRGSMGREKSDKPLPAG 1358

  Fly  1464 T--------GSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSN 1520
            |        |||:...:|.|..  :|.|.:|.:  .|..:.....::|.......||:..| .|.
  Rat  1359 TARPNTFLRGSSKDLLDNQSQE--EQRREMLET--VKQLTGGVDAERASTEADRSKARELV-KSE 1418

  Fly  1521 VNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVS 1585
            |.|.|                    ||....:...|.:.| .||::.|.:.:: ..||.|    .
  Rat  1419 VCTVP--------------------APDKPALSEEEVERK-SKSIIDEFLHIN-DFKEAT----Q 1457

  Fly  1586 CIKRVPEKLRCSFIYYILTDYLHL-ANVGKQY--------RRYLSIAVSQLIQQNYISADHLRLA 1641
            ||:.:..:           ..||: ..||.::        |.::...:.||:|...:|.......
  Rat  1458 CIEELSAQ-----------GPLHVFVKVGVEFTLERSQITRDHMGHLLYQLVQSEKLSKQDFFKG 1511

  Fly  1642 YNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYC 1706
            ::|....|:|:.:|||.:|||:.:...|::.:..:::.:|.....|...|...|...|...|...
  Rat  1512 FSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELIVEFSKPLLPVGRAGVLLSEILHLL 1576

  Fly  1707 TQEVGPNFARNMWIKFNLKWSDFMPESE-VADFIKFNRLEYVENES--KSPVIDHRETPEKHVKN 1768
            .:::.......:|.:.:|.|.||:||.| |.:|:...:|::.|:|.  .|..:..:|...:.:.
  Rat  1577 CRQMSHKKVSALWREADLSWKDFLPEGEDVHNFLLEQKLDFTESEGPCSSEALSKKELSAEELS- 1640

  Fly  1769 VIDHIEHLLKEGTTAD-CIIDYSNGNIMVVDKLFIRGLTETLSNF-SIHYKDNSYKLESETFQKF 1831
              ..:|.|:.|....| .|.|:.....:.|    :.||....|.| .:|...
  Rat  1641 --QRLEKLIMEDKADDERIFDWVEVQTLTV----LCGLCRMASGFLRVHITS------------- 1686

  Fly  1832 CIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELY 1876
              |:|..:..|.......|:||:.|......:.|.::..|...|:
  Rat  1687 --PLLNTFYPSCASGFCACMYTVYLKFRDCFYKRSVIFTLFIYLF 1729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	Atrophin-1	<304..>449	CDD:460830	36/153 (24%)
		YppG	322..>379	CDD:372950	14/56 (25%)
		MIF4G	1004..1252	CDD:397130	104/250 (42%)
		MA3	1562..1677	CDD:397128	27/123 (22%)
		W2_eIF4G1_like	1764..1895	CDD:211397	22/115 (19%)
Eif4g3	XP_038965571.1	PHA03247	<65..498	CDD:223021	112/557 (20%)
		MIF4G	969..1197	CDD:397130	104/251 (41%)
		MA3	1435..1547	CDD:397128	28/128 (22%)