DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G1 and Eif4g1

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	XP_006248643.1	Gene:	Eif4g1 / 287986	RGDID:	1306144	Length:	1599	Species:	Rattus norvegicus

Alignment Length:	1816	Identity:	463/1816 - (25%)
Similarity:	734/1816 - (40%)	Gaps:	428/1816 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 PASTAEYV-STGNNNSGNTRSNPQSGGIFRG----------PPSTPNAPRGASGGATR---HVHV 324
            |..||..| ||......||.|.|:.|| ||.          |||:. |.|..|....|   ..||
  Rat    25 PGQTAPVVFSTPQATQMNTPSQPRQGG-FRSLQHFYPSRAQPPSSA-ASRVQSAAPARPGPAPHV 87

  Fly   325 QPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAPAPMPYYQYQYVPTLQQQPPHTRSAVTVNT 389
            .|..||.:   |:        |.|.::.||...|           |:      |...||...|.|
  Rat    88 YPAGSQVM---MI--------PSQISYSASQGAY-----------YI------PGQGRSTYVVPT 124

  Fly   390 NVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVG 454
                  ...|||  |..|...||||.::.           .|..|...|..::.|
  Rat   125 ------QQYPVQ--PGAPGFYPGASPTEF-----------GTYAGAYYPAQSVQQ---------- 160

  Fly   455 VMTTSVQP------QPVQVQPASRRRHQHRLQIIDPTT-KKNILDDFDKTKSNTDNEFSDQVTST 512
             ...||.|      ||.|:.|   :|.:..::|.||.. .|:|.:           |......:.
  Rat   161 -FPASVAPAPVLMNQPPQIAP---KRERKTIRIRDPNQGGKDITE-----------EIMSGARTA 210

  Fly   513 NTPATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIETTPISRTD---VGPTPIVSA 574
            :||....:.|.:. ||...                  .:|.:.:...|..|:.   :|..|.:..
  Rat   211 STPTPPQTGGSLE-PQPNG------------------ESPQVAVIIRPDDRSQGAAIGGRPGLPG 256

  Fly   575 MTDAPSVEILPTPQRGRSKKIPIVSPKNVSESIVAPITDETDDAGSTPISRATEESMP------- 632
            ...:|..|..|:.........||:.|.:.|...|..|..:|...|..|||  .|||.|
  Rat   257 PEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTMTTGMIPIS--VEESTPISCESGE 319

  Fly   633 -------PNQTHPNLLI----------SDSSKHKQAVSNSEISKDA----PTGLKEMHVAELESS 676
                   |....|.|.:          |:.|.....||.|.:...|    |.|:  :...:||..
  Rat   320 PYCLSPEPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTSLVPHRAETHEPNGV--IPSEDLEPE 382

  Fly   677 VASENHPA-GILDVNVNKSSQSLDFSADPEIDSIGAISPTS----------------PNA----- 719
            |.|...|| ..|....::|...:..:|.||....||.||.:                |:|
  Rat   383 VESSTEPAPPPLSACASESLVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVPSAALASI 447

  Fly   720 VSPILHEVLDNTELSKKLENSTTERFKDSQSVEKPTHQELSLRNATDETEISAMALQDVNSLDNN 784
            |||.......:|..::: |....:..:|.::..:...::|.|    |.|.:.|...|::......
  Rat   448 VSPTPPVAPSDTSAAQE-EEIEEDEDEDGEAESEKGGEDLPL----DSTPVPAQLSQNLEVAAAP 507

  Fly   785 QIEKTYPSK----PKLN--------------VDVS-EDISSRESAIKSTSTKNTGVDVGLQSDSK 830
            |:..:.|.:    .:||              ||.: .::.::.....:.|.::.| ...|....:
  Rat   508 QVAVSVPKRRRKIKELNKKEAVGDLLDAFKEVDPAVPEVENQPPTGSNPSPESEG-SAALPQPEE 571

  Fly   831 PETTLNDKQDSTDLKVKVSAKISSIIN---------YNEGQWSPNNPSGKKQYDREQLLQLREVK 886
            .|.|.:.|:|          ||.:..|         |...||.|.|...||:||||.||..:.:.
  Rat   572 AEETWDSKED----------KIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIF 626

  Fly   887 ASRIQPE----VKNV---------------SILPQPNLMPSFIRNNNNNKRVQSMVGIIGNRSNE 932
            ||..:||    :.:|               |.||..|..|.|..:..|..|     ..:.:|...
  Rat   627 ASMQKPEGLPHITDVVLDKANKTPLRSLDPSRLPGINCGPDFTPSFANLGR-----PTLSSRGPP 686

  Fly   933 SAGNYIGKQMSMSGVQSG-GGRSSMKG------MIHVNLSLNQDVKLSENENAWRP----RVLNK 986
            ..|.  |.::. .|.|:| |.|.|.:|      .|..::.:.:|:||::.|.||:|    ...:|
  Rat   687 RGGP--GGELP-RGPQAGLGPRRSQQGPRKETRKIISSVIMTEDIKLNKAEKAWKPSSKRTAADK 748

  Fly   987 SDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEP 1051
            ..|:.||..:..:| |.||||.|||||||:.|..|::::.:|.|||.:::..||.|:|||||.||
  Rat   749 DRGEEDADGSKTQD-LFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEP 812

  Fly  1052 NFSVSYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIV 1116
            ||||:||.:|:.|.| :||    ..:|..:.:.:||..||::.::||.::.......|||.:
  Rat   813 NFSVAYANMCRCLMA-LKV----PTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQK--- 869

  Fly  1117 DKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHSED 1181
             ::.:...|.|:..|:..|||.....||||.|.::|||||||:.|||..|::.|:..||..|.|:
  Rat   870 -EMDEAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEE 933

  Fly  1182 MLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFMLQDVI 1246
            .|||||:||||:|...:......:       :::...:|:.|..:     .:.|||:|||||||:
  Rat   934 SLECLCRLLTTIGKDLDFAKAKPR-------MDQYFNQMEKIIKE-----KKTSSRIRFMLQDVL 986

  Fly  1247 DLRKNKWQTSR-NEAPKTMGQIEKEAKNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGES 1310
            |||::.|...| ::.|||:.||.|||:.|:
  Rat   987 DLRQSNWVPRRGDQGPKTIDQIHKEAEMEE----------------------------------- 1016

  Fly  1311 RSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVSGGAGHSNGNN------DENTWH-VQTSKGSRSL 1368
                     |.:     :::.||....||:...|.......|      |:..|: |..|||||
  Rat  1017 ---------HRE-----HIKVQQLMAKGGDKRRGGPPGPPVNRGLPLVDDGGWNTVPISKGSR-- 1065

  Fly  1369 AVDSNKLEGLSKLS--DQNLETKKMGGLTQFIW----------ISSDTTRLSSAPTPTPSNPFAV 1421
            .:|:::|..::|..  |.|.:....||  :..|          ..|||.  |.|..|...|.|:.
  Rat  1066 PIDTSRLTKITKPGSIDSNNQLFAPGG--RLSWGKGSSGGSGAKPSDTA--SEATRPATLNRFSA 1126

  Fly  1422 LSSL--IDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRT 1484
            |...  ::...|.|...||           |:.|:|.::      ...:|.|...|.|||.:|..
  Rat  1127 LQQTLPVENTDNRRVVQRS-----------SLSRERGEK------AGDRGDRLERSERGGDRGDR 1174

  Fly  1485 LLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQ--------- 1540
            |..:             :.|.|:.:...:....|....:.|  .|..:..|.|..:
  Rat  1175 LDRA-------------RTPATKRSFSKEVEERSRERPSQP--EGLRKAASLTEDRGRDPVKREA 1224

  Fly  1541 TTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIKRVPE-KLRCSFIYYILT 1604
            |...|:|....:...|.:.| .|:::.|.:.|:...:     ||.|::.:.. .|...|:...:.
  Rat  1225 TLPPVSPPKAALAVDEVERK-SKAIIEEYLHLNDMKE-----AVQCVQELASPSLLFIFVRLGIE 1283

  Fly  1605 DYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVY-----ANDLIVDIPELWLYIL 1664
            ..|..:.:.:::       :.:|:.| .:.|.||..|.....:|     |.|:.:|||.:|||:.
  Rat  1284 STLERSTIAREH-------MGRLLHQ-LLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYLA 1340

  Fly  1665 QFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMWIKFNLKWSDF 1729
            :...|::.:..:.:.:|:....|...|...|...|...|....:.:||.....:|.:..|.|.:|
  Rat  1341 ELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWREF 1405

  Fly  1730 MPE-SEVADFIKFNRLEY-VENESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNG 1792
            :.| .:|..|:...::|| :..||::|  ..|....:.::.   .:|.|||:|.:...:.|:...
  Rat  1406 LAEGQDVGSFVAEKKVEYTLGEESEAP--GQRALAFEELRR---QLEKLLKDGGSNQRVFDWIEA 1465

  Fly  1793 NI---MVVDKLFIRGLTETLSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYTL 1854
            |:   .:.....:|.|..|:...:|.: :...:::.:.. |....:||:|: |:|..:|:.||.|
  Rat  1466 NLNEQQIASNTLVRALMTTVCYSAIIF-ETPLRVDVQVL-KVRARLLQKYL-SDEQKELQALYAL 1527

  Fly  1855 QLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKD--QSAGKGVAVKSLNPFFNSL 1913
            |.||..||.|..||......|||..|:::::...|..|||  :..|||||:||:..|||.|
  Rat  1528 QALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWL 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	100/247 (40%)
		MA3	1562..1677	CDD:280933	25/120 (21%)
		W2_eIF4G1_like	1764..1895	CDD:211397	37/135 (27%)
Eif4g1	XP_006248643.1	MIF4G	764..992	CDD:280935	100/248 (40%)
		MA3	1241..1353	CDD:280933	26/125 (21%)
		W2_eIF4G1_like	1440..1569	CDD:211397	37/134 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3545
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I2228
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	1	1.000	-	-		otm45802
orthoMCL	1	0.900	-	-		OOG6_101572
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1015
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.830