DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment eIF4G1 and Paip1

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	NP_663432.1	Gene:	Paip1 / 218693	MGIID:	2384993	Length:	400	Species:	Mus musculus

Alignment Length:	317	Identity:	74/317 - (23%)
Similarity:	123/317 - (38%)	Gaps:	76/317 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   971 KLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLT--PERFDTLVE---EIIKLKI 1030
            |||.|...:.|...:.:..:|......:...|...|:..||.||  |..|:|.:|   |.:...:
Mouse    48 KLSANAPEFYPSGYSSNYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGWV 112

  Fly  1031 DTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTE 1095
            .|.|.:.|::.|::::|...||||...||||..|:..:.:         ...|.:||..||.:..
Mouse   113 TTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTI---------SPQSGNFRQLLLQRCR 168

  Fly  1096 QEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELF--- 1157
            .|:                         :|.::|      .:.:...|:|....|.|:|||:
Mouse   169 TEY-------------------------EAKDQA------AKGDEVTRKRFHAFVLFLGELYLNL 202

  Fly  1158 KISMLTGKI---------IYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSL 1213
            :|....|::         :...::.|.:...:|.|.|..|||...|:..|.|           ..
Mouse   203 EIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDT-----------WK 256

  Fly  1214 EKSITRMQAIASKTDKD--GARVSSRVRFMLQDVIDLRKNKW------QTSRNEAPK 1262
            ||..|.|:.|..:.:..  .|..|..|:.||..:::||.:.|      .|.|...|:
Mouse   257 EKGKTDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPE 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	63/266 (24%)
		MA3	1562..1677	CDD:280933
		W2_eIF4G1_like	1764..1895	CDD:211397
Paip1	NP_663432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		PABPC1-interacting motif-2 (PAM2). /evidence=ECO:0000250	37..64		5/15 (33%)
		MIF4G	81..297	CDD:280935	63/266 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..376
		PABPC1-interacting motif-1 (PAM1). /evidence=ECO:0000250	361..400
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810