DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G1 and Eif4g1

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	XP_006521998.1	Gene:	Eif4g1 / 208643	MGIID:	2384784	Length:	1601	Species:	Mus musculus

Alignment Length:	1817	Identity:	466/1817 - (25%)
Similarity:	737/1817 - (40%)	Gaps:	428/1817 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   274 PASTAEYV-STGNNNSGNTRSNPQSGGIFRG----------PPSTPNAPRGASGGATR---HVHV 324
            |..||..| ||......||.|.|:.|| ||.          |||:. |.|..|....|   ..||
Mouse    25 PGQTAPVVFSTPQATQMNTPSQPRQGG-FRSLQHFYPSRAQPPSSA-ASRVQSAAPARPGPAPHV 87

  Fly   325 QPMYSQPLHQNMVLQQYTQYNPRQQTFPASHLQYAPAPMPYYQYQYVPTLQQQPPHTRSAVTVNT 389
            .|..||.:   |:        |.|.::.||...|           |:      |...||...|.|
Mouse    88 YPAGSQVM---MI--------PSQISYSASQGAY-----------YI------PGQGRSTYVVPT 124

  Fly   390 NVNVGNNLQPVQSGPNGPLPVPGASSSQIQLLTSTVQPGASTVMGVGGPGSTMGQVGVPPMVGVG 454
                  ...|||  |..|...||||.::.                    |:..|  ...|..||.
Mouse   125 ------QQYPVQ--PGAPGFYPGASPTEF--------------------GTYAG--AYYPAQGVQ 159

  Fly   455 VMTTSVQP------QPVQVQPASRRRHQHRLQIIDPTT-KKNILDDFDKTKSNTDNEFSDQVTST 512
            ....||.|      ||.|:.|   :|.:..::|.||.. .|:|.:           |......:.
Mouse   160 QFPASVAPAPVLMNQPPQIAP---KRERKTIRIRDPNQGGKDITE-----------EIMSGARTA 210

  Fly   513 NTPATVLSEGPIRIPQQESVGLNNLTSTSSQGSESRTNAPYIPIETTPISRTD---VGPTPIVSA 574
            :||....:.|.:. ||...                  .:|.:.:...|..|:.   :|..|.:..
Mouse   211 STPTPPQTGGSLE-PQPNG------------------ESPQVAVIIRPDDRSQGAAIGGRPGLPG 256

  Fly   575 MTDAPSVEILPTPQRGRSKKIPIVSPKNVSESIVAPITDETDDAGSTPISRATEESMPPN-QTHP 638
            ...:|..|..|:.........||:.|.:.|...|..|..:|...|..|:|  .|||.|.: :|..
Mouse   257 PEHSPGTESQPSSPSPTPSPPPILEPGSESNLGVLSIPGDTMTTGMIPMS--VEESTPISCETGE 319

  Fly   639 NLLISDSSKHKQAVSNSEISKDAPTGLKEMHVAELESSVASENH------PAGI-----LDVNVN 692
            ...:|......:.:...|::...|....|...:.|:.|.|...|      |.|:     |:..|.
Mouse   320 PYCLSPEPTLAEPILEVEVTLSKPIPESEFSSSPLQVSTALVPHKVETHEPNGVIPSEDLEPEVE 384

  Fly   693 KSSQSLDFSADPEI-----DSIGAISPT-----------SPNAVSPILHEVLDNTELSKKLENST 741
            .|::    .|.|.:     :|:..|:||           ||.||.  |..|.:..|.:||:.::.
Mouse   385 SSTE----PAPPPLSPCASESLVPIAPTAQPEELLNGAPSPPAVD--LSPVSEPEEQAKKVSSAA 443

  Fly   742 TERFKDSQSVEKPTH----QELSLRNATDETE----ISAMALQDVNSLDNNQIEKTYPSKPKLNV 798
            ............|:.    ||..:....|:.|    .|....:|| .||:..:    |::...|:
Mouse   444 LASILSPAPPVAPSDTSPAQEEEMEEDDDDEEGGEAESEKGGEDV-PLDSTPV----PAQLSQNL 503

  Fly   799 DVSE------DISSRESAIKSTSTKN------------------------TGVDVGLQSD----- 828
            :|:.      .:..|...||..:.|.                        ||.:...:|:
Mouse   504 EVAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEVDPAVPEVENQPPTGSNPSPESEGSMVP 568

  Fly   829 SKPETTLNDKQDSTDLKVKVSAKI---SSIINYNEGQWSPNNPSGKKQYDREQLLQLREVKASRI 890
            ::||.| .:..||.:.|:..:..|   .....|...||.|.|...||:||||.||..:.:.||..
Mouse   569 TQPEET-EETWDSKEDKIHNAENIQPGEQKYEYKSDQWKPLNLEEKKRYDREFLLGFQFIFASMQ 632

  Fly   891 QPE----VKNV---------------SILPQPNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGN 936
            :||    :.:|               |.||..|..|.|..:..|..|     ..:.||.....|.
Mouse   633 KPEGLPHITDVVLDKANKTPLRQLDPSRLPGINCGPDFTPSFANLGR-----PALSNRGPPRGGP 692

  Fly   937 YIGKQMSMSGVQSG-GGRSSMKG------MIHVNLSLNQDVKLSENENAWRP----RVLNKSDGD 990
              |.::. .|.|:| |.|.|.:|      .|..::.:.:|:||::.|.||:|    ...:|..|:
Mouse   693 --GGELP-RGPQAGLGPRRSQQGPRKETRKIISSVIMTEDIKLNKAEKAWKPSSKRTAADKDRGE 754

  Fly   991 SDAKSALEKDELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSV 1055
            .||..:..:| |.||||.|||||||:.|..|::::.:|.|||.:::..||.|:|||||.||||||
Mouse   755 EDADGSKTQD-LFRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSV 818

  Fly  1056 SYARLCQRLAAEVKVIDERMESETKSNSAHFRNALLDKTEQEFTQNVSQSTAKEKKLQPIVDKIK 1120
            :||.:|:.|.| :||    ..:|..:.:.:||..||::.::||.::.......|||.:    ::.
Mouse   819 AYANMCRCLMA-LKV----PTTEKPTVTVNFRKLLLNRCQKEFEKDKDDDEVFEKKQK----EMD 874

  Fly  1121 KCTDANEKAELEAFLEEEERKIRRRSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHSEDMLEC 1185
            :...|.|:..|:..|||.....||||.|.::|||||||:.|||..|::.|:..||..|.|:.|||
Mouse   875 EAATAEERGRLKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLEC 939

  Fly  1186 LCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITRMQAIASKTDKDGARVSSRVRFMLQDVIDLRK 1250
            ||:||||:|...:......:       :::...:|:.|..:     .:.|||:|||||||:|||:
Mouse   940 LCRLLTTIGKDLDFAKAKPR-------MDQYFNQMEKIIKE-----KKTSSRIRFMLQDVLDLRQ 992

  Fly  1251 NKWQTSR-NEAPKTMGQIEKEA---------KNEQLSAQYFGTLSSTTPGGSQGGSGKRDDRGNS 1305
            :.|...| ::.|||:.||.|||         |.:||.|:               ||.||  ||..
Mouse   993 SNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKVQQLMAK---------------GSDKR--RGGP 1040

  Fly  1306 RYGESRSSSAYGGSHSQRG----DNGNLRHQQQNNVGGNVSGGAGHSNGNNDENTWH-VQTSKGS 1365
                       .|....||    |:|.                            |: |..||||
Mouse  1041 -----------PGPPINRGLPLVDDGG----------------------------WNTVPISKGS 1066

  Fly  1366 RSLAVDSNKLEGLSKLS--DQNLETKKMGGLTQFIW----------ISSDTTRLSSAPTPTPSNP 1418
            |  .:|:::|..::|..  |.|.:....||  :..|          ..|||.  |.|..|...|.
Mouse  1067 R--PIDTSRLTKITKPGSIDSNNQLFAPGG--RLSWGKGSSGGSGAKPSDTA--SEATRPATLNR 1125

  Fly  1419 FAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGR 1483
            |:.|...:...:.:         |:....:.|:.|:|.::      ...:|.|...|.|||.:|.
Mouse  1126 FSALQQTLPAENTD---------NRRVVQRSSLSRERGEK------AGDRGDRLERSERGGDRGD 1175

  Fly  1484 TLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQ-------- 1540
            .|..:             :.|.|:.:...:....|....:.|  .|..:..|.|..:
Mouse  1176 RLDRA-------------RTPATKRSFSKEVEERSRERPSQP--EGLRKAASLTEDRGRDPVKRE 1225

  Fly  1541 -TTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIKRVPE-KLRCSFIYYIL 1603
             |...|:|....:...|.: |..|:::.|.:.|:...:     ||.|::.:.. .|...|:...:
Mouse  1226 ATLPPVSPPKAALSVDEVE-KKSKAIIEEYLHLNDMKE-----AVQCVQELASPSLLFIFVRLGI 1284

  Fly  1604 TDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVY-----ANDLIVDIPELWLYI 1663
            ...|..:.:.:::       :.:|:.| .:.|.||..|.....:|     |.|:.:|||.:|||:
Mouse  1285 ESTLERSTIAREH-------MGRLLHQ-LLCAGHLSTAQYYQGLYETLELAEDMEIDIPHVWLYL 1341

  Fly  1664 LQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNMWIKFNLKWSD 1728
            .:...|::.:..:.:.:|:....|...|...|...|...|....:.:||.....:|.:..|.|.:
Mouse  1342 AELITPILQEDGVPMGELFREITKPLRPMGKATSLLLEILGLLCKSMGPKKVGMLWREAGLSWRE 1406

  Fly  1729 FMPE-SEVADFIKFNRLEY-VENESKSPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSN 1791
            |:.| .:|..|:...::|| :..||::|  ..|....:.::.   .:|.|||:|.:...:.|:.:
Mouse  1407 FLAEGQDVGSFVAEKKVEYTLGEESEAP--GQRTLAFEELRR---QLEKLLKDGGSNQRVFDWID 1466

  Fly  1792 GNI---MVVDKLFIRGLTETLSNFSIHYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYT 1853
            .|:   .:.....:|.|..|:...:|.: :...:::.:.. |....:||:|: .:|..:|:.||.
Mouse  1467 ANLNEQQIASNTLVRALMTTVCYSAIIF-ETPLRVDVQVL-KVRARLLQKYL-CDEQKELQALYA 1528

  Fly  1854 LQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKD--QSAGKGVAVKSLNPFFNSL 1913
            ||.||..||.|..||......|||..|:::::...|..|||  :..|||||:||:..|||.|
Mouse  1529 LQALVVTLEQPANLLRMFFDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFNWL 1590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	100/247 (40%)
		MA3	1562..1677	CDD:280933	25/120 (21%)
		W2_eIF4G1_like	1764..1895	CDD:211397	36/135 (27%)
Eif4g1	XP_006521998.1	PHA03247	<4..463	CDD:223021	123/538 (23%)
		rad2	<373..>612	CDD:273166	50/250 (20%)
		MIF4G	766..994	CDD:367217	100/248 (40%)
		MA3	1243..1355	CDD:367215	26/125 (21%)
		W2_eIF4G1_like	1442..1571	CDD:211397	36/134 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I3633
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2325
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	1	1.000	-	-		otm43729
orthoMCL	1	0.900	-	-		OOG6_101572
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R596
SonicParanoid	1	1.000	-	-		X1015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.860