Protein Alignment eIF4G1 and EIF4G2

DIOPT Version :10

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: NP_001409.3
• Gene: EIF4G2 / 1982
• HGNCID: 3297
• Length: 907
• Species: Homo sapiens
• Alignment Length: 1064
• Identity: 254/1064 - (23%)
• Similarity: 430/1064 - (40%)
• Gaps: 273/1064 - (25%)

  Fly   943 SMSGVQSGGGRSSMKGMIHVNLSLNQDV---KLSENENAWRP-RVLNKSDGDSDAKSALEK---D 1000
            |.....||||.|......:...:.|.:.   ...:|...|.| |...:.|..:...||.||   |
Human    11 SRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHD 75

  Fly  1001 ELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLA 1065
            .:.|:|||||||||||:||.|..|::.:.:::...:..||:|:.:||::||.:|..||:||.|||
Human    76 AIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLA 140

  Fly  1066 AEVKVID----ERMESETKSNSAHFRNALLDKTEQEF---TQNVSQSTAKEKKLQPIVDKIKKCT 1123
            .:....|    |....:.:|.:  ||..|:.|.:.||   |:||.....:|..|.|
Human   141 EDAPNFDGPAAEGQPGQKQSTT--FRRLLISKLQDEFENRTRNVDVYDKRENPLLP--------- 194

  Fly  1124 DANEKAELEAFLEEEERKIRR-RSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHS----EDM- 1182
                       .|||:|.|.: :..|.::|||||.|:.::...|::.||.|||....    :||
Human   195 -----------EEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMG 248

  Fly  1183 --LECLCKLLTTVGAKFEKTPVNSKDPSRCYSL-EKSITRMQAIASKTDKDGARVSSRVRFMLQD 1244
              |||||:::.|||.:.        |..|..|| ::...||.::....:     :.:|:||:|||
Human   249 EDLECLCQIMRTVGPRL--------DHERAKSLMDQYFARMCSLMLSKE-----LPARIRFLLQD 300

  Fly  1245 VIDLRKNKWQTSR---NEAPKTMGQIEKEAKN-----------EQLSAQYF-------------- 1281
            .::||::.|...:   :..|||:.||.::|..           :.:.:.:|
Human   301 TVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGMRSDFFLEGPFMPPRMKMDR 365

  Fly  1282 ---GTLS---STTPGGSQG-GSGKRDDRGNSRYGESRSSSAYGG--------SHSQRGDNGNLRH 1331
               |.|:   ...||...| |.|...||.:...|..||:..:.|        :.||.|:
Human   366 DPLGGLADMFGQMPGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGE------ 424

  Fly  1332 QQQNNVGGNVSGGAGHSNGNNDENTWHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGGLTQ 1396
                 :||......|.|      ..:|.| |:|..|      :|:|.||  |......|.|.|
Human   425 -----MGGKFMKSQGLS------QLYHNQ-SQGLLS------QLQGQSK--DMPPRFSKKGQL-- 467

  Fly  1397 FIWISSDTTRLSSAPTPTPSNPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRGMH 1461
                ::|...|..|.           |.|::||...:
Human   468 ----NADEISLRPAQ-----------SFLMNKNQVPK---------------------------- 489

  Fly  1462 SRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTGPL 1526
                             .|...|::..|.|...:      |.||...|.:.........:...|
Human   490 -----------------LQPQITMIPPSAQPPRT------QTPPLGQTPQLGLKTNPPLIQEKP- 530

  Fly  1527 YRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIK--R 1589
                        ::|::...|      :.|..|||.::||:|.::...|::     ||:.::  |
Human   531 ------------AKTSKKPPP------SKEELLKLTETVVTEYLNSGNANE-----AVNGVREMR 572

  Fly  1590 VPEKLRCSFIYYILTDYLHLA-NVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYANDLI 1653
            .|:    .|:..:|:..:.|: :...:.:...|..:|.|.|:...::|:...|:.........|.
Human   573 APK----HFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLDQCPKLE 633

  Fly  1654 VDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFARNM 1718
            ||||.:..|:.|||...|:.::::||:|       ..|......|  ...:.|.|::.....|.
Human   634 VDIPLVKSYLAQFAARAIISELVSISEL-------AQPLESGTHF--PLFLLCLQQLAKLQDRE- 688

  Fly  1719 WI-------KFNLKWSDFMPESEVADFIKFNRLEYVENESKS---PVIDHRETPEKHVKNVID-- 1771
            |:       |.|::  ..:||   .|..|...||.:|.:..|   |::...:...|.:|  :|
Human   689 WLTELFQQSKVNMQ--KMLPE---IDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIK--LDPS 746

  Fly  1772 --HIEHLLKEGTTADCIIDYSNGNIMVVDKLFIRGLTETLSNFSIHYKDNS----YKLESE---- 1826
              .|...:|:..:....:|....||::..  |::.::..::..|.....:|    .:||.|
Human   747 PQTIYKWIKDNISPKLHVDKGFVNILMTS--FLQYISSEVNPPSDETDSSSAPSKEQLEQEKQLL 809

  Fly  1827 -TFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWR 1890
             :|:    ||:|:::..:.|.|:..||.||:..:....|:|:|.......||..:|::|:...|:
Human   810 LSFK----PVMQKFLHDHVDLQVSALYALQVHCYNSNFPKGMLLRFFVHFYDMEIIEEEAFLAWK 870

  Fly  1891 -DSKDQSAGKGVAVKSLNPFFNSL 1913
             |...:..|||.|:..:|.:...|
Human   871 EDITQEFPGKGKALFQVNQWLTWL 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	Atrophin-1	<304..>449	CDD:460830
		YppG	322..>379	CDD:372950
		MIF4G	1004..1252	CDD:397130	88/263 (33%)
		MA3	1562..1677	CDD:397128	27/117 (23%)
		W2_eIF4G1_like	1764..1895	CDD:211397	33/144 (23%)
EIF4G2	NP_001409.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..71		14/59 (24%)
		MIF4G	78..308	CDD:397130	88/264 (33%)
		PRK12757	<436..>543	CDD:237191	32/208 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	498..541		9/67 (13%)
		MA3	544..657	CDD:214714	30/121 (25%)
		W2_eIF4G1_like	740..876	CDD:211397	32/143 (22%)