DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G1 and Eif4g2

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	NP_038535.2	Gene:	Eif4g2 / 13690	MGIID:	109207	Length:	906	Species:	Mus musculus

Alignment Length:	1067	Identity:	256/1067 - (23%)
Similarity:	428/1067 - (40%)	Gaps:	280/1067 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   943 SMSGVQSGGGRSSMKGMIHVNLSLNQDV---KLSENENAWRP-RVLNKSDGDSDAKSALEK---D 1000
            |.....||||.|......:...:.|.:.   ...:|...|.| |...:.|..:...||.||   |
Mouse    11 SRFSASSGGGGSRGAPQHYPKTAGNSEFLGKTPGQNAQKWIPARSTRRDDNSAANNSANEKERHD 75

  Fly  1001 ELVRRVRGILNKLTPERFDTLVEEIIKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLA 1065
            .:.|:|||||||||||:||.|..|::.:.:::...:..||:|:.:||::||.:|..||:||.|||
Mouse    76 AIFRKVRGILNKLTPEKFDKLCLELLNVGVESKLILKGVILLIVDKALEEPKYSSLYAQLCLRLA 140

  Fly  1066 AEVKVID----ERMESETKSNSAHFRNALLDKTEQEF---TQNVSQSTAKEKKLQPIVDKIKKCT 1123
            .:....|    |....:.:|.:  ||..|:.|.:.||   |:||.....:|..|.|
Mouse   141 EDAPNFDGPAAEGQPGQKQSTT--FRRLLISKLQDEFENRTRNVDVYDKRENPLLP--------- 194

  Fly  1124 DANEKAELEAFLEEEERKIRR-RSGGTVRFIGELFKISMLTGKIIYSCIDTLLNPHS----EDM- 1182
                       .|||:|.|.: :..|.::|||||.|:.::...|::.||.|||....    :||
Mouse   195 -----------EEEEQRAIAKIKMLGNIKFIGELGKLDLIHESILHKCIKTLLEKKKRVQLKDMG 248

  Fly  1183 --LECLCKLLTTVGAKFEKTPVNSKDPSRCYSL-EKSITRMQAIASKTDKDGARVSSRVRFMLQD 1244
              |||||:::.|||.:.        |..|..|| ::...||.::....:     :.:|:||:|||
Mouse   249 EDLECLCQIMRTVGPRL--------DHERAKSLMDQYFARMCSLMLSKE-----LPARIRFLLQD 300

  Fly  1245 VIDLRKNKWQTSR---NEAPKTMGQIEKEA---------------KNEQL--------------- 1276
            .::||::.|...:   :..|||:.||.::|               :|:..
Mouse   301 TVELREHHWVPRKAFLDNGPKTINQIRQDAVKDLGVFIPAPMAQGRNDFFLEGPFMPPRMKMDRD 365

  Fly  1277 ----SAQYFGTLSSTTPGGSQG-GSGKRDDRGNSRYGESRSSSAYGG--------SHSQRGDNGN 1328
                .|..||.:    ||...| |.|...||.:...|..||:..:.|        :.||.|:
Mouse   366 PLGGLADMFGQM----PGSGIGTGPGVIQDRFSPTMGRHRSNQLFNGHGGHIMPPTQSQFGE--- 423

  Fly  1329 LRHQQQNNVGGNVSGGAGHSNGNNDENTWHVQTSKGSRSLAVDSNKLEGLSKLSDQNLETKKMGG 1393
                    :||......|.|      ..:|.| |:|..|      :|:|.||  |......|.|.
Mouse   424 --------MGGKFMKSQGLS------QLYHNQ-SQGLLS------QLQGQSK--DMPPRFSKKGQ 465

  Fly  1394 LTQFIWISSDTTRLSSAPTPTPSNPFAVLSSLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDR 1458
            |      ::|...|..|.           |.|::||...:
Mouse   466 L------NADEISLRPAQ-----------SFLMNKNQVPK------------------------- 488

  Fly  1459 GMHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNT 1523
                                .|...|::..|.|...:      |.||...|.:.........:..
Mouse   489 --------------------LQPQITMIPPSAQPPRT------QTPPLGQTPQLGLKTNPPLIQE 527

  Fly  1524 GPLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSVVSEIVDLSAASKEVTPGAVSCIK 1588
            .|             ::|::...|      :.|..|||.::||::.::...|:     .|||.::
Mouse   528 KP-------------AKTSKKPPP------SKEELLKLTEAVVTDYLNSGNAN-----DAVSGVR 568

  Fly  1589 --RVPEKLRCSFIYYILTDYLHLA-NVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNEFTVYAN 1650
              |.|:    .|:..:|:..:.|: :...:.:...|..:|.|.|:...::|:...|:........
Mouse   569 EMRAPK----HFLPEMLSKVIILSLDRSDEDKEKASSLISLLKQEGIATSDNFMQAFLNVLEQCP 629

  Fly  1651 DLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQEVGPNFA 1715
            .|.||||.:..|:.|||...|:.::::||:|       ..|......|  ...:.|.|::.....
Mouse   630 KLEVDIPLVKSYLAQFAARAIISELVSISEL-------AQPLESGTHF--PLFLLCLQQLAKLQD 685

  Fly  1716 RNMWI-------KFNLKWSDFMPESEVADFIKFNRLEYVENESKS---PVIDHRETPEKHVKNVI 1770
            |. |:       |.|::  ..:||   .|..|...||.:|.:..|   |::...:...|.:|  :
Mouse   686 RE-WLTELFQQSKVNMQ--KMLPE---IDQNKDRMLEILEGKGLSFLFPLLKLEKELLKQIK--L 742

  Fly  1771 D----HIEHLLKEGTTADCIIDYSNGNIMVVDKLFIRGLTETLSNFSIHYKDNS----YKLESE- 1826
            |    .|...:|:..:....:|....||::..  |::.::..:|..|.....:|    .:||.|
Mouse   743 DPSPQTIYKWIKDNISPKLHVDKGFVNILMTS--FLQYISSEVSPPSDETDSSSAPSKEQLEQEK 805

  Fly  1827 ----TFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLC 1887
                :|:    ||:|:::..:.|.|:..||.||:..:....|:|:|.......||..:|::|:..
Mouse   806 QLLLSFK----PVMQKFLHDHVDLQVSALYALQVHCYNSSFPKGMLLRFFVHFYDMEIIEEEAFL 866

  Fly  1888 KWR-DSKDQSAGKGVAVKSLNPFFNSL 1913
            .|: |...:..|||.|:..:|.:...|
Mouse   867 AWKEDITQEFPGKGKALFQVNQWLTWL 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935	88/263 (33%)
		MA3	1562..1677	CDD:280933	27/117 (23%)
		W2_eIF4G1_like	1764..1895	CDD:211397	34/144 (24%)
Eif4g2	NP_038535.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		14/59 (24%)
		MIF4G	78..308	CDD:280935	88/264 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..540		9/67 (13%)
		MA3	543..656	CDD:214714	30/121 (25%)
		W2_eIF4G1_like	739..875	CDD:211397	33/143 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0401
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D594395at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23253
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920