Protein Alignment eIF4G1 and eif4g3

DIOPT Version :10

• Sequence 1: NP_001096852.1
• Gene: eIF4G1 / 43839
• FlyBaseID: FBgn0023213
• Length: 1919
• Species: Drosophila melanogaster
• Sequence 2: XP_031760741.1
• Gene: eif4g3 / 100216088
• XenbaseID: XB-GENE-1010293
• Length: 1740
• Species: Xenopus tropicalis
• Alignment Length: 1836
• Identity: 455/1836 - (24%)
• Similarity: 734/1836 - (39%)
• Gaps: 425/1836 - (23%)

  Fly   302 RGPPSTPNAPRG--ASGGATRHVHVQPMYS---QPLHQNMVLQQYTQYNPRQQTFPASHLQYAPA 361
            :|.|:....|.|  ||.|.:     |..|:   .|....:|   |.|......|.|.:...:|..
 Frog    96 KGHPNLAATPPGHAASPGLS-----QASYASGQSPAAPTLV---YPQPPQTMSTQPQNRSPFAAG 152

  Fly   362 PMP------YYQYQYVPTLQQQPP---------------HTRSAV-TVNTNVNVGNNLQPVQSGP 404
            |.|      :...|:....|.|||               .|.:|| ..|.::.:.|:|....:.|
 Frog   153 PRPAHHQGGFRPIQFFQRTQIQPPRAAIQTSSPSIRAGAQTPTAVYQTNQHIMMVNHLPMPYAMP 217

  Fly   405 NGP-LPVPGASSSQIQLLTSTVQ-----PGASTVMGVGGPGSTMGQVGVP-----------PMVG 452
            .|| ..:|....|....:....|     ||.|......|||......|.|           |:
 Frog   218 QGPQYCIPQYRHSAPPYVGPPQQYPVQPPGPSPFYPGPGPGDFPTPYGAPFYSSQPVYQSAPI-- 280

  Fly   453 VGVMTTSVQPQPVQVQPASRRRHQHRLQIIDPTT-KKNILDDFDKTKSNTDNEFSDQVTSTNTPA 516
              ::.|..|.||    |...:|.:..::|.||.. .|:|.:           |....|.|.|:..
 Frog   281 --IVPTQQQQQP----PPPAKREKKPIRIRDPNQGGKDITE-----------EIMSGVGSRNSTP 328

  Fly   517 TVLSEGPIRIPQQESVGLNNLTSTSSQGSE------SRTNAPYIP--IETTPISRTD-------- 565
            .:|.......|.|:         ..||..|      ....:|::|  ....|:|...
 Frog   329 PILRPNSTPTPPQQ---------LPSQAPEHGPVVYGTMESPHLPATFPAAPVSEPKPEEKPKPE 384

  Fly   566 ----------VGPTPIVSAMTDAPSVEILPTPQRGRSKKI-PIVSPKNVSESIVAPIT------- 612
                      |.|.|:....:|.  :|..|.|......:: |.:.|...:..||.||.
 Frog   385 HTVKATPPPCVRPDPVDIGTSDV--IEQTPRPASSERPELQPCLLPGVTAAPIVVPIVPTAQAFP 447

  Fly   613 ---DETDDAGSTPISRATEESMPPNQTHPNLLISDSSKHKQAVSNSEISK----DAPTGLKEMHV 670
               |:|..:.|....||...|.|..        ||.::.::.|....:.:    |||.....:..
 Frog   448 CHLDDTRGSESPAEVRAPTPSTPQE--------SDPAETEEVVCKDPVGQVAPADAPLPASALPA 504

  Fly   671 AEL-----------------ESSVASENHP-----AGILDV--------NVNKSSQSLDFSADPE 705
            .|:                 ||::|..:.|     |..:|.        ||..||.:|  ||.|.
 Frog   505 QEMNGLGDDMAGTAAGAAGEESALAEVDLPEVPGLAAPMDADAECTTSSNVPLSSPAL--SASPL 567

  Fly   706 IDS-----IGAISPTSPNAVSPILHEVLD-------------------NTELSKKLENS------ 740
            .||     ..::||.:....:....:|.:                   .||...:||:|
 Frog   568 PDSPPPLIAASLSPPASALATLCAQDVAEQEDGRAATLESDGEGQGKGRTEGDSELESSVKLLSI 632

  Fly   741 -------------TTERFKDSQSVEKPTHQELSLRNATDETEISAMALQD-VNSLDNN------- 784
                         |..:.......|.|..:|:|  .:..|.:.....|:| |..||.:
 Frog   633 NSKKSPVEAPAAITAPKMWQKPKDESPDIEEIS--QSETEPQYEDDPLEDKVTELDQDPVTYSGT 695

  Fly   785 ---QIEKTY--PSKPKLNVDVSEDISSRESAIKSTSTKN--TGVDVGLQSDSKPETTLNDKQDST 842
               ::|:.|  .:||:......|.|.:...|:..:...:  :|.:.||   :.|.:
 Frog   696 STMEVEQLYLNNAKPQEQNGEVEPIRNGADAVSESEGTDIPSGTEEGL---AYPYS--------- 748

  Fly   843 DLKVKVSAKISSIINYNEGQWSPNNPSGKKQYDREQLLQLREVKASRIQPE----VKNVSI--LP 901
              |..:.|.........|....|.:..||:||||:.||..:.:.|...:||    :.:|.:  :.
 Frog   749 --KAGIGAAEQPPDPSQEPPAPPQSADGKRQYDRDFLLGFQYMPACVQKPEGLPPISDVVLDKIN 811

  Fly   902 QPNLMPSFIRNNNNNKRVQSMVGIIGNRSNESAGNYIGKQMSMSGVQSGGGRSSMKGM------I 960
            ||.| |....:....:|.........:....:.|   |:.|.:..|   |.|.|..|.      |
 Frog   812 QPKL-PIRALDARMLQRGPDFTPAYADFGRPAPG---GRGMPLLSV---GPRRSQPGQRREPRKI 869

  Fly   961 HVNLSLNQDVKLSENENAWRPRVLNKSDGDSDAKSALEKDELVRRVRGILNKLTPERFDTLVEEI 1025
            .:|:|::.||.|.::||||:|.|  |.|...:...::....|.|:||.|||||||:.|:.|::::
 Frog   870 IMNISVSDDVHLKKSENAWKPSV--KRDSLPEDPDSIRTQALFRKVRSILNKLTPQMFNQLMKQV 932

  Fly  1026 IKLKIDTPDKVDEVIVLVFEKAIDEPNFSVSYARLCQRLAA-EVKVIDERMESETKSNSAHFRNA 1089
            ..|.:||.:::..||.||||||||||:|||:||.:|:.||. :|.:.|:      ..::.:||..
 Frog   933 TDLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLATLKVPMADK------PGSTVNFRKL 991

  Fly  1090 LLDKTEQEFTQNVSQSTAKEKKLQPIVDKIKKCTDANEKAELEAFLEEEERKIRRRSGGTVRFIG 1154
            ||::.::||.::.:.....|||.:    .::..|...||:.|:..|||.:.|.||||.|.::|||
 Frog   992 LLNRCQKEFEKDKADDDVFEKKQK----DLELATTPEEKSRLQDELEESKDKARRRSIGNIKFIG 1052

  Fly  1155 ELFKISMLTGKIIYSCIDTLLNPHSEDMLECLCKLLTTVGAKFEKTPVNSKDPSRCYSLEKSITR 1219
            ||||:.|||..|::.|:..||..|.|:.|||||:||||:|          ||    ...||:..|
 Frog  1053 ELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIG----------KD----LDFEKAKPR 1103

  Fly  1220 MQAIASKTDK--DGARVSSRVRFMLQDVIDLRKNKWQTSR-NEAPKTMGQIEKEAK----NEQLS 1277
            |....::.:|  ...:.|||:|||||||||||.:.|.:.| ::.|||:.||.||||    .||..
 Frog  1104 MDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLSNWVSRRADQGPKTIEQIHKEAKIEEQEEQRK 1168

  Fly  1278 AQYFGTLSSTTPGGSQGGSGKRDDRGNSRYGESRSSSAYGGSHSQRGDNGNLRHQQQNNVGGNVS 1342
            .|...|.....|.|.|
 Frog  1169 VQQLMTKEKRRPAGVQ------------------------------------------------- 1184

  Fly  1343 GGAGHSNGNNDENTWH-VQTSKGSRSLAVDSNKLEGLSKLS-DQNLE--TKKMGGLTQFIWI--S 1401
                    ..||..|: ||.:|.:|.|  |.:|...::|.: |:.::  .|...|    .|:  |
 Frog  1185 --------RVDEGGWNTVQGAKNNRVL--DPSKFLKITKPTIDEKIQLVPKAQPG----SWLKGS 1235

  Fly  1402 SDTTRLSSAPTPTPSNP----FAVLS---SLIDKNSNERDRDRSGPRNKGSYNKGSMERDRYDRG 1459
            |...:.|...:..|..|    |:.|.   |.:..:|:....:....|...| ::||..|::.|:
 Frog  1236 SGGAKASETESLRPGAPSLNRFSALQQPLSSVSSSSSSSPSELDSRRLLTS-SRGSTGREKNDK- 1298

  Fly  1460 MHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYTQQAPPTRHTVKAQSSVGSSNVNTG 1524
                  .|..|...|:.|.|    |||..|.:.|..:.:..::  .|..|||..::|...:.||.
 Frog  1299 ------PSAPSSIPSAPRPG----TLLRGSSKDSADNQEELRR--ETLQTVKQLTNVAEPDKNTV 1351

  Fly  1525 PLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLI---------KSVVSEIVDLSAASKEVT 1580
            |..|..|...|                 |.||.|...:         |:::.|.:.::...:
 Frog  1352 PERRPKEPAKS-----------------EPSEPDKPTLSEEEMERKSKAIIDEFLHINDYKE--- 1396

  Fly  1581 PGAVSCIKRVPEKLRCS-FIYYILTDYLHLANVGKQYRRYLSIAVSQLIQQNYISADHLRLAYNE 1644
              |:.|::.:......| |:...:...|..:.:.:.:...|   :.||:|...:|.......::|
 Frog  1397 --AMQCVEELGANGPLSVFVRQGVESTLERSQITRDHMGQL---LYQLVQSGKLSKLDFFTGFSE 1456

  Fly  1645 FTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVAKKFLKTYLIYCTQE 1709
            ....|:|:.:|||.:|||:.:...|::.:..:::.:|.....|...|.....:.|...|....::
 Frog  1457 TLELADDMAIDIPHIWLYLAELVTPMLKEGGISLRELITEFGKALLPVGRGGELLSEILHLLCKQ 1521

  Fly  1710 VGPNFARNMWIKFNLKWSDFMPESE-VADFIKFNRLEYVENESKSPVIDHRETPEKHVKNVIDHI 1773
            :.......:|.:..|:|.|.:||.| |..|:....||:..::|.|| .::....|...:.:...:
 Frog  1522 MSHKRVAALWRETGLRWRDLLPEGEDVQSFVSEKNLEFTLSDSSSP-SENLSKKEMSAEELHKRL 1585

  Fly  1774 EHL-LKEGTTADCIIDYSNGNI---MVVDKLFIRGLTETLSNFSIHYKDNSYKLESETFQKFCIP 1834
            |.| ::|....:.|.|:...::   .:....|:|.|...:...:|....:|.:::. ||.|..:|
 Frog  1586 EQLIIQEKANDEQIFDWVEASLDESQMSSPTFLRALMTAVCKAAILGDCSSCRVDI-TFLKQRVP 1649

  Fly  1835 VLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAFVIQKESLCKWRDSKD--QSA 1897
            ||.:|:||:.:.:|:.||.||.|:..|:.|..:|......|||..||.:::..||..|||  :..
 Frog  1650 VLLKYLDSDTERELQALYALQALIVKLDQPPNVLRMFFDCLYDEEVISEDAFYKWESSKDPAEQE 1714

  Fly  1898 GKGVAVKSLNPFFNSL 1913
            |||||:||:..||..|
 Frog  1715 GKGVALKSVTAFFTWL 1730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	Atrophin-1	<304..>449	CDD:460830	42/188 (22%)
		YppG	322..>379	CDD:372950	14/65 (22%)
		MIF4G	1004..1252	CDD:397130	106/250 (42%)
		MA3	1562..1677	CDD:397128	22/124 (18%)
		W2_eIF4G1_like	1764..1895	CDD:211397	38/136 (28%)
eif4g3	XP_031760741.1	PHA03247	<73..493	CDD:223021	92/442 (21%)
		MIF4G	910..1138	CDD:397130	106/251 (42%)
		MA3	1378..1489	CDD:397128	22/118 (19%)
		W2_eIF4G1_like	1579..1711	CDD:211397	38/132 (29%)
		W2	<1690..1736	CDD:473053	20/41 (49%)