DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment eIF4G1 and wu:fb16f03

DIOPT Version :9

Sequence 1:	NP_001096852.1	Gene:	eIF4G1 / 43839	FlyBaseID:	FBgn0023213	Length:	1919	Species:	Drosophila melanogaster
Sequence 2:	XP_017206776.1	Gene:	wu:fb16f03 / 100006548	ZFINID:	ZDB-GENE-030131-196	Length:	456	Species:	Danio rerio

Alignment Length:	491	Identity:	130/491 - (26%)
Similarity:	206/491 - (41%)	Gaps:	59/491 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1436 DRSGPRNKGSYNKGSMERDRYDRGMHSRTGSSQGSRENSSSRGGQQGRTLLSSSVQKSTSHSKYT 1500
            ||:|.|.:|...:|| :|:|...|..|   .|:...|.|..|..||.    ||.|.:..| |..|
Zfish     2 DRAGDRYEGRDERGS-DRNRPAVGKRS---FSREKEERSREREQQQH----SSEVLRRGS-STTT 57

  Fly  1501 QQAPPTRHTVKAQSSVGSSNVNTGPLYRGSEQQTSATFSQTTRSVAPVAVFIEASETDLKLIKSV 1565
            ......|...:.:|:...|...|.|....:.:..........:|.|.:..::..:  |||.....
Zfish    58 DHRERDRERERERSAKRESVAATPPPPAAASKPALTEEELEKKSTAIIEEYLHIN--DLKEALQC 120

  Fly  1566 VSEIVDLSAASKEVTPGAVSCIKRVPEKLRCSFIYYILTDYLHLANVGKQYRRYLSIAVSQLIQQ 1630
            |||:...|..|..|..|..|.::|..                 ||      |.:|.:...||::.
Zfish   121 VSELNCSSLLSVFVRTGIESTLERST-----------------LA------REHLGLLFHQLLKT 162

  Fly  1631 NYISADHLRLAYNEFTVYANDLIVDIPELWLYILQFAGPLIVKKILTISDLWNNNLKENSPSNVA 1695
            ..::.........|....|.|:.:|||.:|||:.:...|::.:..:.:..|:....|...|...|
Zfish   163 QTLTTQQYYKGLMEVLEVAEDMAIDIPHIWLYLAELICPMLHEGGIPMGPLFRELSKPLLPLGKA 227

  Fly  1696 KKFLKTYLIYCTQEVGPNFARNMWIKFNLKWSDFMP-ESEVADFIKFNRLEY-------VENESK 1752
            ...|...|....:.:....|..||.:..|.|.:|:| :.:|..|:....:|:       |...||
Zfish   228 GVLLVEILKQLCKGMSHKKAGVMWREAGLNWREFLPDDQDVNKFVTEQAVEFTVLGEESVFEGSK 292

  Fly  1753 SPVIDHRETPEKHVKNVIDHIEHLLKEGTTADCIIDYSNGNI---MVVDKLFIRGLTETLSNFSI 1814
            |.:...:.:.|         :|.||:|......|:|:...|:   .....:.:|.|..::...||
Zfish   293 SSLSPAQISAE---------LERLLQEKADNQRILDWLEANLDEQQATSNMLVRVLMTSVCQSSI 348

  Fly  1815 HYKDNSYKLESETFQKFCIPVLQRYIDSNEDHQLECLYTLQLLVHGLEHPRGLLSELIGELYDAF 1879
             ..||.||::::...:.. .:||||| .:|..:|:.||.||.|:..:|.|..||......|||..
Zfish   349 -ICDNPYKVDTKEMSQRA-KLLQRYI-KDEQKELQALYALQALMVQMEQPPNLLRMFFDVLYDED 410

  Fly  1880 VIQKESLCKWRDSKD--QSAGKGVAVKSLNPFFNSL 1913
            ||::|...:|..|||  :..|||||:||:..||..|
Zfish   411 VIKEEGFYRWESSKDPAEQQGKGVALKSVTAFFTWL 446

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
eIF4G1	NP_001096852.1	MIF4G	1004..1252	CDD:280935
		MA3	1562..1677	CDD:280933	25/114 (22%)
		W2_eIF4G1_like	1764..1895	CDD:211397	41/135 (30%)
wu:fb16f03	XP_017206776.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11343
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001079
OrthoInspector	1	1.000	-	-		otm24848
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910