DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and Gprc5d

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001192325.1	Gene:	Gprc5d / 93746	MGIID:	1935037	Length:	344	Species:	Mus musculus

Alignment Length:	272	Identity:	58/272 - (21%)
Similarity:	112/272 - (41%)	Gaps:	51/272 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   626 FALIPMAIAIFGIALTSIVIVLF----AKNHDTPLVRASGRELSYTL----LFGILVCYCNTFAL 682
            :|::..::|:.||.:|.::::.|    .|..|.........:..:.|    |||:      |||.
Mouse    22 WAIVLESLAVIGIVVTILLLLAFLFLMRKVQDCSQWNVLPTQFLFLLAVLGLFGL------TFAF 80

  Fly   683 IAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSL-- 745
            |.:....:..::.|..||.|:|.:|.||...:.:             :|.:..:.....||.|
Mouse    81 IIQLNHQTAPVRYFLFGVLFAICFSCLLAHASNL-------------VKLVRGRVSFCWTTILFI 132

  Fly   746 -IAIQVLITMIWM----VVEPPGTRFYY--PDRREVILKCKIQDMSFLFSQLYNMILITICTIYA 803
             |.:.:|.|:|.:    ::...|..|.:  |.:..|...|.:..:.||.:..:.:...|.|.
Mouse   133 AIGVSLLQTIIAIEYVTLIMTRGLMFEHMTPYQLNVDFVCLLIYVLFLMALTFFVSKATFCG--- 194

  Fly   804 IKTRKIP-ENFNE-SKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQ----TTTLCISISLSASVA 862
                  | ||:.: .:.|..|:..:.|||:.::.:........:.|    ...:||.:..:|.|.
Mouse   195 ------PCENWKQHGRLIFATVLVSIIIWVVWISMLLRGNPQLQRQPHWDDAVICIGLVTNAWVF 253

  Fly   863 LVCLYSPKVYIL 874
            |:....|::.||
Mouse   254 LLIYIIPELSIL 265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141
		ANF_receptor	72..518	CDD:279440
		NCD3G	557..604	CDD:284890
		7tm_3	638..873	CDD:278433	53/257 (21%)
Gprc5d	NP_001192325.1	7tm_3	61..264	CDD:278433	48/230 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910