Protein Alignment mGluR and Tas1r3

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_114078.1
• Gene: Tas1r3 / 83771
• MGIID: 1933547
• Length: 858
• Species: Mus musculus
• Alignment Length: 936
• Identity: 235/936 - (25%)
• Similarity: 383/936 - (40%)
• Gaps: 179/936 - (19%)

  Fly    43 GDIILGGLFPVHEKGEGA----------PCGPKVYNR----GVQRLEAMLYAIDRVNNDPNILPG 93
            ||.|||||||:....|..          ||     ||    |:....||..|::.:||...:|||
Mouse    33 GDYILGGLFPLGSTEEATLNQRTQPNSIPC-----NRFSPLGLFLAMAMKMAVEEINNGSALLPG 92

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYS 158
            :.:|..:.||||.....:..||.|: |.:.:...:.|.......|:         |..|||...|
Mouse    93 LRLGYDLFDTCSEPVVTMKSSLMFL-AKVGSQSIAAYCNYTQYQPR---------VLAVIGPHSS 147

  Fly   159 SVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTI 223
            .::|........|.:||||.:::...|||:..|..|.||||.|..|..|:|.:|:||:|::|:.:
Mouse   148 ELALITGKFFSFFLMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAAL 212

  Fly   224 HSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADD-----KVFDSIISKLQKKPNARGVVLFT 283
            .|:..||..|:......|..|.:|||....||.....     ||.|.:....|.|  .:.||||.
Mouse   213 GSDDDYGREGLSIFSSLANARGICIAHEGLVPQHDTSGQQLGKVLDVLRQVNQSK--VQVVVLFA 275

  Fly   284 RAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAE-GAITVELQ-SEIIADFDRYM 346
            .|.....:...:....|| |..|:||:.| ....|:..|.:||. |.:...|| ..::.:|..|:
Mouse   276 SARAVYSLFSYSIHHGLS-PKVWVASESW-LTSDLVMTLPNIARVGTVLGFLQRGALLPEFSHYV 338

  Fly   347 MQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANS----TDNKIGVKAKTECDD----- 402
                 ||:                  .:|:..|....|.|:    .::.:|.:. ..|||
Mouse   339 -----ETH------------------LALAADPAFCASLNAELDLEEHVMGQRC-PRCDDIMLQN 379

  Fly   403 -SYRLSEKVGYEQESKTQFVV-DAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKIS 465
             |..|.:.:...|.....|.. .|||:.|.||||  ..:||......:|   |:..   |
Mouse   380 LSSGLLQNLSAGQLHHQIFATYAAVYSVAQALHN--TLQCNVSHCHVSE---HVLP---W----- 431

  Fly   466 TDTKSQACPDMANYDGKEFYNNYLLNVSF--IDLAGSEVKFDRQGDGLARYDILNYQRQENSSGY 528
                             :...| :.|:||  .||.   ::||.:|:....||:..:..|  |...
Mouse   432 -----------------QLLEN-MYNMSFHARDLT---LQFDAEGNVDMEYDLKMWVWQ--SPTP 473

  Fly   529 QYKVIGKWFNG-LQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQG-DTCCWICDSCESFEYVY 591
            ....:|. ||| |||....:.| ...:.|.|.||..|:.|.:::.:| .:||:.|..|::..|..
Mouse   474 VLHTVGT-FNGTLQLQQSKMYW-PGNQVPVSQCSRQCKDGQVRRVKGFHSCCYDCVDCKAGSYRK 536

  Fly   592 --DEFTCKDCGPGLWPYADKLSCYALDIQYMKWNS--LFALIPMAIAIFGIALTSIVIVLFAKNH 652
              |:|||..|....|......:|.....:::.|..  :.:|:.:...:.|:||.:  :.|...:.
Mouse   537 HPDDFTCTPCNQDQWSPEKSTACLPRRPKFLAWGEPVVLSLLLLLCLVLGLALAA--LGLSVHHW 599

  Fly   653 DTPLVRASGRELSYTLLFGILVC---YCNTFALI-AKPTIGSCVLQRFGIGVGFSIIYSALLTKT 713
            |:|||:|||   .....|| |:|   :|.:..|. .:|:..||:.|:          ..|.|..|
Mouse   600 DSPLVQASG---GSQFCFG-LICLGLFCLSVLLFPGRPSSASCLAQQ----------PMAHLPLT 650

  Fly   714 NRISRIFHSASKS--------------AQRLKYISPQSQVVITT---------SLIAIQVLITMI 755
            ..:|.:|..|:::              ...|:.:.....|::.|         .|||....:...
Mouse   651 GCLSTLFLQAAETFVESELPLSWANWLCSYLRGLWAWLVVLLATFVEAALCAWYLIAFPPEVVTD 715

  Fly   756 WMVVEPPGTRFYYPDRREVILKCKIQD-MSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFI 819
            |.|:.           .||:..|.::. :|.....:.|.:|..:|.:.....:..|..:|.::.:
Mouse   716 WSVLP-----------TEVLEHCHVRSWVSLGLVHITNAMLAFLCFLGTFLVQSQPGRYNRARGL 769

  Fly   820 GFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRK 884
            .|.|....|.|::|||:......:|  |......:|.:.|...||..:.||.|:|::.|..|.::
Mouse   770 TFAMLAYFITWVSFVPLLANVQVAY--QPAVQMGAILVCALGILVTFHLPKCYVLLWLPKLNTQE 832

  Fly   885 LTMNSTVYRRSAAAVAQGAPTSSGYS 910
            ..:.... :::|...:.|...:.|::
Mouse   833 FFLGRNA-KKAADENSGGGEAAQGHN 857

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	145/533 (27%)
		NCD3G	556..605	CDD:462210	17/51 (33%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	62/278 (22%)
		TM helix 1	625..650	CDD:320600	5/24 (21%)
		TM helix 2	662..683	CDD:320600	5/23 (22%)
		TM helix 3	692..716	CDD:320600	4/23 (17%)
		TM helix 4	738..758	CDD:320600	6/28 (21%)
		TM helix 5	781..807	CDD:320600	4/26 (15%)
		TM helix 6	815..838	CDD:320600	7/22 (32%)
		TM helix 7	845..870	CDD:320600	5/24 (21%)
Tas1r3	NP_114078.1	Periplasmic_Binding_Protein_type1	29..502	CDD:471960	149/549 (27%)
		NCD3G	500..552	CDD:462210	17/51 (33%)
		7tm_GPCRs	597..823	CDD:475119	56/252 (22%)
		TM helix 2	609..630	CDD:320417	6/21 (29%)
		TM helix 3	639..661	CDD:320417	6/31 (19%)
		TM helix 4	688..704	CDD:320417	2/15 (13%)
		TM helix 5	731..754	CDD:320417	4/22 (18%)
		TM helix 6	766..788	CDD:320417	7/21 (33%)
		TM helix 7	793..818	CDD:320417	6/26 (23%)