DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Tas1r3

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_114078.1	Gene:	Tas1r3 / 83771	MGIID:	1933547	Length:	858	Species:	Mus musculus

Alignment Length:	936	Identity:	235/936 - (25%)
Similarity:	383/936 - (40%)	Gaps:	179/936 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVHEKGEGA----------PCGPKVYNR----GVQRLEAMLYAIDRVNNDPNILPG 93
            ||.|||||||:....|..          ||     ||    |:....||..|::.:||...:|||
Mouse    33 GDYILGGLFPLGSTEEATLNQRTQPNSIPC-----NRFSPLGLFLAMAMKMAVEEINNGSALLPG 92

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYS 158
            :.:|..:.||||.....:..||.|: |.:.:...:.|.......|:         |..|||...|
Mouse    93 LRLGYDLFDTCSEPVVTMKSSLMFL-AKVGSQSIAAYCNYTQYQPR---------VLAVIGPHSS 147

  Fly   159 SVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTI 223
            .::|........|.:||||.:::...|||:..|..|.||||.|..|..|:|.:|:||:|::|:.:
Mouse   148 ELALITGKFFSFFLMPQVSYSASMDRLSDRETFPSFFRTVPSDRVQLQAVVTLLQNFSWNWVAAL 212

  Fly   224 HSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADD-----KVFDSIISKLQKKPNARGVVLFT 283
            .|:..||..|:......|..|.:|||....||.....     ||.|.:....|.|  .:.||||.
Mouse   213 GSDDDYGREGLSIFSSLANARGICIAHEGLVPQHDTSGQQLGKVLDVLRQVNQSK--VQVVVLFA 275

  Fly   284 RAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAE-GAITVELQ-SEIIADFDRYM 346
            .|.....:...:....|| |..|:||:.| ....|:..|.:||. |.:...|| ..::.:|..|:
Mouse   276 SARAVYSLFSYSIHHGLS-PKVWVASESW-LTSDLVMTLPNIARVGTVLGFLQRGALLPEFSHYV 338

  Fly   347 MQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANS----TDNKIGVKAKTECDD----- 402
                 ||:                  .:|:..|....|.|:    .::.:|.:. ..|||
Mouse   339 -----ETH------------------LALAADPAFCASLNAELDLEEHVMGQRC-PRCDDIMLQN 379

  Fly   403 -SYRLSEKVGYEQESKTQFVV-DAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKIS 465
             |..|.:.:...|.....|.. .|||:.|.||||  ..:||......:|   |:..   |
Mouse   380 LSSGLLQNLSAGQLHHQIFATYAAVYSVAQALHN--TLQCNVSHCHVSE---HVLP---W----- 431

  Fly   466 TDTKSQACPDMANYDGKEFYNNYLLNVSF--IDLAGSEVKFDRQGDGLARYDILNYQRQENSSGY 528
                             :...| :.|:||  .||.   ::||.:|:....||:..:..|  |...
Mouse   432 -----------------QLLEN-MYNMSFHARDLT---LQFDAEGNVDMEYDLKMWVWQ--SPTP 473

  Fly   529 QYKVIGKWFNG-LQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQG-DTCCWICDSCESFEYVY 591
            ....:|. ||| |||....:.| ...:.|.|.||..|:.|.:::.:| .:||:.|..|::..|..
Mouse   474 VLHTVGT-FNGTLQLQQSKMYW-PGNQVPVSQCSRQCKDGQVRRVKGFHSCCYDCVDCKAGSYRK 536

  Fly   592 --DEFTCKDCGPGLWPYADKLSCYALDIQYMKWNS--LFALIPMAIAIFGIALTSIVIVLFAKNH 652
              |:|||..|....|......:|.....:::.|..  :.:|:.:...:.|:||.:  :.|...:.
Mouse   537 HPDDFTCTPCNQDQWSPEKSTACLPRRPKFLAWGEPVVLSLLLLLCLVLGLALAA--LGLSVHHW 599

  Fly   653 DTPLVRASGRELSYTLLFGILVC---YCNTFALI-AKPTIGSCVLQRFGIGVGFSIIYSALLTKT 713
            |:|||:|||   .....|| |:|   :|.:..|. .:|:..||:.|:          ..|.|..|
Mouse   600 DSPLVQASG---GSQFCFG-LICLGLFCLSVLLFPGRPSSASCLAQQ----------PMAHLPLT 650

  Fly   714 NRISRIFHSASKS--------------AQRLKYISPQSQVVITT---------SLIAIQVLITMI 755
            ..:|.:|..|:::              ...|:.:.....|::.|         .|||....:...
Mouse   651 GCLSTLFLQAAETFVESELPLSWANWLCSYLRGLWAWLVVLLATFVEAALCAWYLIAFPPEVVTD 715

  Fly   756 WMVVEPPGTRFYYPDRREVILKCKIQD-MSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFI 819
            |.|:.           .||:..|.::. :|.....:.|.:|..:|.:.....:..|..:|.::.:
Mouse   716 WSVLP-----------TEVLEHCHVRSWVSLGLVHITNAMLAFLCFLGTFLVQSQPGRYNRARGL 769

  Fly   820 GFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRK 884
            .|.|....|.|::|||:......:|  |......:|.:.|...||..:.||.|:|::.|..|.::
Mouse   770 TFAMLAYFITWVSFVPLLANVQVAY--QPAVQMGAILVCALGILVTFHLPKCYVLLWLPKLNTQE 832

  Fly   885 LTMNSTVYRRSAAAVAQGAPTSSGYS 910
            ..:.... :::|...:.|...:.|::
Mouse   833 FFLGRNA-KKAADENSGGGEAAQGHN 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	145/533 (27%)
		ANF_receptor	72..518	CDD:279440	123/465 (26%)
		NCD3G	557..604	CDD:284890	16/49 (33%)
		7tm_3	638..873	CDD:278433	58/262 (22%)
Tas1r3	NP_114078.1	Periplasmic_Binding_Protein_Type_1	29..494	CDD:299141	147/540 (27%)
		ANF_receptor	73..469	CDD:279440	123/467 (26%)
		NCD3G	501..551	CDD:284890	16/49 (33%)
		7tm_3	597..821	CDD:278433	55/250 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000