Protein Alignment mGluR and TAS1R3

DIOPT Version :9

• Sequence 1: NP_001259076.1
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_016857924.1
• Gene: TAS1R3 / 83756
• HGNCID: 15661
• Length: 894
• Species: Homo sapiens
• Alignment Length: 939
• Identity: 214/939 - (22%)
• Similarity: 376/939 - (40%)
• Gaps: 191/939 - (20%)

  Fly    36 SVSVSLPGDIILGGLFPVHEKGEGA------PCGP---KVYNRGVQRLEAMLYAIDRVNNDPNIL 91
            |..:.:.||.:||||||:.|..|..      |..|   :..:.|:....||..|::.:||..::|
Human    26 SQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINNKSDLL 90

  Fly    92 PGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGS 156
            ||:.:|..:.||||....|:..||.|: |...:.|.:.|.......|:         |..|||..
Human    91 PGLRLGYDLFDTCSEPVVAMKPSLMFL-AKAGSRDIAAYCNYTQYQPR---------VLAVIGPH 145

  Fly   157 YSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVS 221
            .|.:::........|.:||||..::.:.||.:..|..|.||||.|..|..|..::|:.|.|::|:
Human   146 SSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAELLQEFGWNWVA 210

  Fly   222 TIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQ------KKPNARGVV 280
            .:.|:..||..|:......|..|.:|||....||....|   ||.:.|:|      .:.:.:.|:
Human   211 ALGSDDEYGRQGLSIFSALAAARGICIAHEGLVPLPRAD---DSRLGKVQDVLHQVNQSSVQVVL 272

  Fly   281 LFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAE-GAITVELQ-SEIIADFD 343
            ||.....|..:...:..:.|| |..|:||:.| ....|:.||..:|: |.:...|| ...:.:|.
Human   273 LFASVHAAHALFNYSISSRLS-PKVWVASEAW-LTSDLVMGLPGMAQMGTVLGFLQRGAQLHEFP 335

  Fly   344 RYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVK--------AKTEC 400
            :|                         |.|.|::..|.:..:...:.:.|::        .:.:|
Human   336 QY-------------------------VKTHLALATDPAFCSALGEREQGLEEDVVGQRCPQCDC 375

  Fly   401 DDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKIS 465
            .....:|..:.:.|   |..|..|||:.|.||||  ..:||
Human   376 ITLQNVSAGLNHHQ---TFSVYAAVYSVAQALHN--TLQCN------------------------ 411

  Fly   466 TDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQY 530
                :..||........:...| :.|::| .:.|..::||..|:....||:..:..|  .|..:.
Human   412 ----ASGCPAQDPVKPWQLLEN-MYNLTF-HVGGLPLRFDSSGNVDMEYDLKLWVWQ--GSVPRL 468

  Fly   531 KVIGKWFNGLQLNSETVVWN-KETEQPTSACSLPCEVGMIKKQQG-DTCCWICDSCES------- 586
            ..:|::...|:.....:.|: .:.::|.|.||..|:.|.:::.:| .:||:.|..||:
Human   469 HDVGRFNGSLRTERLKIRWHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNP 533

  Fly   587 -------------------------------------FEYVYDEFTCKDCGPGLWPYADKLSCYA 614
                                                 |..:.|:..|..||...|.......|:.
Human   534 GEPPSRQAGVGTQQGRVLPSPDSETRAHRVQDEHPAPFSSLTDDIACTFCGQDEWSPERSTRCFR 598

  Fly   615 LDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVC---Y 676
            ...:::.|.....|:.:.:....:.|....:.||..:.|:|||:|||..|:   .|| |||   .
Human   599 RRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPLA---CFG-LVCLGLV 659

  Fly   677 CNTFALI-AKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS----------AQRL 730
            |.:..|. .:|:...|:.|:          ..:.|..|..:|.:|..|::.          |.||
Human   660 CLSVLLFPGQPSPARCLAQQ----------PLSHLPLTGCLSTLFLQAAEIFVESELPLSWADRL 714

  Fly   731 K--YISPQSQVVITTSLIAIQVLITMIWMVVEPPG-TRFYYPDRREVILKCKIQD-MSFLFSQLY 791
            .  ...|.:.:|:..::: ::|.:...::|..||. ...::....|.::.|:.:. :||..:...
Human   715 SGCLRGPWAWLVVLLAML-VEVALCTWYLVAFPPEVVTDWHMLPTEALVHCRTRSWVSFGLAHAT 778

  Fly   792 NMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGT----GNSYEVQTTTLC 852
            |..|..:|.:.....|..|..:|.::.:.|.|....|.|::|||:....    ..:.::....||
Human   779 NATLAFLCFLGTFLVRSQPGCYNRARGLTFAMLAYFITWVSFVPLLANVQVVLRPAVQMGALLLC 843

  Fly   853 ISISLSASVALVCLYSPKVYILVFHPDKN 881
            :...|:|      .:.|:.|:|:..|..|
Human   844 VLGILAA------FHLPRCYLLMRQPGLN 866

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	130/523 (25%)
		ANF_receptor	72..518	CDD:279440	113/461 (25%)
		NCD3G	557..604	CDD:284890	16/91 (18%)
		7tm_3	638..873	CDD:278433	57/256 (22%)
TAS1R3	XP_016857924.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910