Protein Alignment mGluR and GLR3.6

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_190716.3
• Gene: GLR3.6 / 824311
• AraportID: AT3G51480
• Length: 903
• Species: Arabidopsis thaliana
• Alignment Length: 830
• Identity: 163/830 - (19%)
• Similarity: 281/830 - (33%)
• Gaps: 250/830 - (30%)

  Fly    76 AMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQL 140
            ||..|::.||..|:||...|:.:.:.||......::.:.|||:.:.
plant    49 AMDAAVEDVNASPSILNTTTLRIIMHDTKYNGFMSIMEPLQFMESE------------------- 94

  Fly   141 RKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQS 205
                    ...:||...|:.:..||::.....||.:|.::|..|:| ..:|..|.||...|.||.
plant    95 --------TVAIIGPQRSTTARVVAHVATELKIPILSFSATDPTMS-PLQFPFFIRTSQNDLFQM 150

  Fly   206 VALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKL 270
            .|:.||::.:.|..|..|:.:..||..|:.||....:|:...|:....:|.|...:....::.|:
plant   151 AAIADIVQFYGWREVVAIYGDDDYGRNGVAALGDRLSEKRCRISYKAALPPAPTRENITDLLIKV 215

  Fly   271 QKKPNARGVVLFTRAEDARRILQAAKRAN-LSQPFHWIASDGW-----GKQQKL-LEGLEDIAEG 328
            ... .:|.:|:.........:...|:... :|..:.|||:: |     .....| |:.:.:| :|
plant   216 ALS-ESRIIVVHASFIWGLELFNVARNLGMMSTGYVWIATN-WLSTIIDTDSPLPLDTINNI-QG 277

  Fly   329 AITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIG 393
            .||:.|.              ||.:..:.. |.:.|.:     ||.:.:
plant   278 VITLRLH--------------TPNSIMKQN-FVQRWHN-----LTHVGL---------------- 306

  Fly   394 VKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRK------ 452
                    .:|.|             :..|.|:..|.|:.:......|....:.....:
plant   307 --------STYAL-------------YAYDTVWLLAQAIDDFFKKGGNVSFSKNPIISELGGGNL 350

  Fly   453 HLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKF--DRQGDGLARYD 515
            ||.:..|                   :||.:.:...:|.|..|.|.| .:||  ||.....| :|
plant   351 HLDALKV-------------------FDGGKIFLESILQVDRIGLTG-RMKFTSDRNLVNPA-FD 394

  Fly   516 ILNYQRQENSSGYQYKVIGKWFN------------------GLQLNSETVVWNKETEQPTSACSL 562
            :||.      .|..|..||.|||                  |.:|:|  |||      |..:..:
plant   395 VLNV------IGTGYTTIGYWFNHSGLSVMPADEMENTSFSGQKLHS--VVW------PGHSIKI 445

  Fly   563 P-----------CEVGMIKKQQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALD 616
            |           ..:|:..:.:             ||.|   .:.|..|        .::.:.:|
plant   446 PRGWVFSNNGRHLRIGVPNRYR-------------FEEV---VSVKSNG--------MITGFCVD 486

  Fly   617 IQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFA 681
            :.....|    |:|.|:        ...:|.|...||.|    |..||...:..|:.........
plant   487 VFIAAIN----LLPYAV--------PFELVAFGNGHDNP----SNSELVRLITTGVYDAGVGDIT 535

  Fly   682 LIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLI 746
            :|.:.|..:...|.:        :.|.|:.    ::.:....|.:...|:..:||..::...|.:
plant   536 IITERTKMADFTQPY--------VESGLVV----VAPVRKLGSSAMAFLRPFTPQMWLIAAASFL 588

  Fly   747 AIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPE 811
               ::..:||.:.......|..|.||:||       .:|.||         ..|::.........
plant   589 ---IVGAVIWCLEHKHNDEFRGPPRRQVI-------TTFWFS---------FSTLFFSHRETTTS 634

  Fly   812 NFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASV 861
            |...         ...||||..|.|   ..:||....|::.....||:.:
plant   635 NLGR---------IVLIIWLFVVLI---INSSYTASLTSILTVHQLSSPI 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	102/498 (20%)
		NCD3G	556..605	CDD:462210	8/59 (14%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	46/237 (19%)
		TM helix 1	625..650	CDD:320600	5/24 (21%)
		TM helix 2	662..683	CDD:320600	3/20 (15%)
		TM helix 3	692..716	CDD:320600	3/23 (13%)
		TM helix 4	738..758	CDD:320600	3/19 (16%)
		TM helix 5	781..807	CDD:320600	4/25 (16%)
		TM helix 6	815..838	CDD:320600	6/22 (27%)
		TM helix 7	845..870	CDD:320600	3/17 (18%)
GLR3.6	NP_190716.3	PBP1_GABAb_receptor_plant	31..419	CDD:380645	101/484 (21%)
		GluR_Plant	458..797	CDD:270404	54/298 (18%)
		Lig_chan	576..829	CDD:459656	27/128 (21%)