DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and grm8a

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001289157.1	Gene:	grm8a / 792371	ZFINID:	ZDB-GENE-110421-2	Length:	909	Species:	Danio rerio

Alignment Length:	948	Identity:	416/948 - (43%)
Similarity:	567/948 - (59%)	Gaps:	83/948 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VVVMVLSWSRV--VDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGE-GAPCGPKVYNRGVQR 73
            ::|.:..|..|  ..|::|...:..   |:.|.||||||||||||.:|| |.|||.....:|:.|
Zfish    13 LLVFLCYWFPVSLQKLETPPIEYAH---SIRLDGDIILGGLFPVHSRGERGVPCGELKKEKGIHR 74

  Fly    74 LEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSP 138
            |||||:|||.:|.||::||.:|:|..||||||||||||.|||.||:|.:.. |.|...||:|..|
Zfish    75 LEAMLFAIDLINKDPDLLPNVTLGARILDTCSRDTYALEQSLTFVQALIER-DGSDVRCANGDQP 138

  Fly   139 QLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTF 203
            ..   |....:.||||.:.||||:.|||:||||.|||:|.||||..|||.||:|.|:|.||||::
Zfish   139 IF---AKPDKIVGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 200

  Fly   204 QSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKVFDSII 267
            |:.|::||:....|:||||:.|||:|||.|:||..:.:.|. .||||.:.|:|.......||.||
Zfish   201 QAQAMLDIVTAMGWNYVSTLASEGNYGESGVEAFVQISREMGGVCIAQSLKIPREPRAGEFDKII 265

  Fly   268 SKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITV 332
            .:|.:.||||.:::|...:|.||:|.:|||:|.:..|.|:.||.||.:...:...|.:||||||:
Zfish   266 RRLLETPNARAIIMFANEDDIRRVLDSAKRSNQTGHFLWVGSDSWGSKISPVIQQERVAEGAITI 330

  Fly   333 ELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAK 397
            ..:...:..||||....:...|:||.||||:||:.|.|                    |:|:..|
Zfish   331 LPKRATVDAFDRYFRSRSLSNNRRNVWFAEFWEENFGC--------------------KLGMHGK 375

  Fly   398 -----TECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSE 457
                 .:|....::.....||||.|.|||:|||||.|:|||.:|.:.|
Zfish   376 RPGSLKKCTGLEKVGRDSSYEQEGKVQFVMDAVYAMAHALHRMHREYC----------------- 423

  Fly   458 SVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQ 522
             ..|..:        ||.|:|.:|||.. .|:.||||...||:.|.|::.||...||||..|| .
Zfish   424 -FGYPGL--------CPRMSNINGKELL-GYIRNVSFNGSAGTPVVFNQNGDAPGRYDIFQYQ-I 477

  Fly   523 ENSSGYQYKVIGKWFNGLQLNSETVVWNK-ETEQPTSACSLPCEVGMIKK-QQGDTCCWICDSCE 585
            .|.|..:|||||:|.|.|.||...:.|.. :...|.|.||:||::|..|| .:|..|||.|:.||
Zfish   478 TNKSTAEYKVIGQWTNKLHLNVNVMRWRTGDPRLPASVCSVPCQMGERKKIVKGVPCCWHCERCE 542

  Fly   586 SFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAK 650
            .:.:...||:|:.|.....|..::..|..:.|..::|:|.:|.:|:.:|:.||..||.|:|.|.:
Zfish   543 GYHFQASEFSCELCPYEQRPDRNRTGCVPIPIIKLEWHSAWAAVPVFVAVLGILATSFVVVTFVR 607

  Fly   651 NHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNR 715
            .:|||:|||||||:||.||.||.:||..||.:||.|::|.|..:|..:|:|....|:||||||||
Zfish   608 YNDTPIVRASGREMSYVLLTGIFLCYAITFLMIATPSLGICSFRRVFLGLGMCFSYAALLTKTNR 672

  Fly   716 ISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR-------E 773
            |.|||....||....::|||.||:|||.|||::|:|...:|..|:||.|...|.::|       .
Zfish   673 IHRIFEQGKKSVAAPRFISPASQLVITFSLISVQLLGVFVWFAVDPPHTVVDYGEQRTSDPMKAR 737

  Fly   774 VILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYF 838
            .:|||.|.|:|.:.|..|:::|:..||:||||||.:||.|||:|.|||||||||||||||:||:|
Zfish   738 GVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFF 802

  Fly   839 GTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNV--RKLTMNSTVYRRSAAA 898
            ||..|.|   :|||||.||:||||||:|..||.||||:::|||::||  ||.:..:.|    .||
Zfish   803 GTAQSAERMYIQTTTLTISLSLSASVSLGMLYMPKVYVIIFHPEQNVPKRKRSFKAIV----TAA 863

  Fly   899 VAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPT 936
            ...|.....|..|.:....:.|. .::.||.:.||..|
Zfish   864 TMSGKLVQKGSDRPNGEVKTELC-ESMETNTTFSTKTT 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	224/505 (44%)
		ANF_receptor	72..518	CDD:279440	193/451 (43%)
		NCD3G	557..604	CDD:284890	19/47 (40%)
		7tm_3	638..873	CDD:278433	133/244 (55%)
grm8a	NP_001289157.1	Periplasmic_Binding_Protein_Type_1	43..504	CDD:299141	226/512 (44%)
		ANF_receptor	73..477	CDD:279440	195/455 (43%)
		NCD3G	514..560	CDD:284890	19/45 (42%)
		7tm_3	595..840	CDD:278433	133/244 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12113
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820