DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and Vom2r37

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_038947382.1	Gene:	Vom2r37 / 690356	RGDID:	1597332	Length:	865	Species:	Rattus norvegicus

Alignment Length:	897	Identity:	207/897 - (23%)
Similarity:	385/897 - (42%)	Gaps:	147/897 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVHEKGEGAPCGPKVYNRGVQRLE------------AMLYAIDRVNNDPNILPGIT 95
            ||:.:|..||:|....|.....|......|.:.            |:::||:.||.:|::|...|
  Rat    36 GDMTIGAFFPLHILYTGNKVPHKYVPNNFQDVHIQYKFKNYQFVLALMFAIEEVNRNPHLLHNTT 100

  Fly    96 IGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSV 160
            ||..|.:....:...|..:|.:....:|.|.    .|..|..   ||:    ||  |:.|...|.
  Rat   101 IGYDIYNIPYTEKNILYSALLWHTGIINPLP----NCDCGHK---RKS----PV--VLTGPSWSA 152

  Fly   161 SLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHS 225
            |..:..||:|:.|||::......||:|:...:...:..|.||..|:|:|.::.:|:||:|..:..
  Rat   153 SAHIGTLLQLYKIPQLTFGPFDSTLNDQGTSNSLYQMAPKDTSLSLAIVLLMLHFSWSWVGLMLP 217

  Fly   226 EGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK---PNARGVVLFTRAED 287
            :...|...:..|.:......:|||.::.:|...:  .|.:.:.|..:|   .:|..:|::.....
  Rat   218 DDHRGTQFLSDLRENMESNGICIAFSKMIPGTWN--AFSNALWKSMEKIEESSANVIVIYGDIIS 280

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPE 352
            ...:::...:..::... |:.:..|.........:.:...|::......|.:.:|..::..:.|.
  Rat   281 VEGLIRHIAQLLVTWKV-WVLNSSWDVDNHSDYFMVESFHGSLVFSYHHEEMIEFMNFIQTVNPY 344

  Fly   353 TNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESK 417
            ....:.:..::|...|.|..:....:...:...|::   :.:..:...|.:  :||: ||.
  Rat   345 KYPEDDYLPKFWFLFFKCSFSKFDCQLLENCQLNAS---LELLPRHIFDPT--MSEE-GYN---- 399

  Fly   418 TQFVVDAVYAFAYALHNLHNDRCNTQSD-----------------QTTETRKHLQSESVWYRKIS 465
               :.:||||.||:||.|...:...|..                 :||..:.|::..:|.....:
  Rat   400 ---IYNAVYAVAYSLHELSLQQIQIQPYINEKGMVFSPWQLLPFLRTTINKSHVKGHTVMDGGRN 461

  Fly   466 TDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQY 530
            .|||         ||...|:|       |....|.:||       :..|.:.:|:..:.|
  Rat   462 LDTK---------YDILNFWN-------FPSGLGLKVK-------VGTYSLSSYKDVQFS----- 498

  Fly   531 KVIGKWFNGLQLNSETVVW-NKETEQPTSACSLPCEVGMIK-KQQGD-TCCWICDSCESFEY--V 590
                       |....:.| .:.|:.|.|.||..|..|:.| .|:|. .||:.|..|...|.  .
  Rat   499 -----------LCEGMIQWPTRFTKIPQSVCSESCRPGLRKAAQEGKAVCCFDCTPCAENEISNE 552

  Fly   591 YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAI------FGIALTSIVIVLFA 649
            .|...|..|....:..|:|..|....:.::.:..     |:.:|:      |.: ||::|:|:|.
  Rat   553 TDMDQCVKCPESHYANAEKNHCLRKSVSFLAYEE-----PLGMALTITALGFSV-LTAVVLVVFV 611

  Fly   650 KNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTN 714
            |:.|||:|:|:.|.|||.||..:.:|:.::...|.:|...:|:||:...|:.|::..|.:|.|..
  Rat   612 KHRDTPIVKANNRSLSYILLLTLFICFLSSLLFIGQPRTATCILQQTAFGILFTVALSTVLAKAI 676

  Fly   715 RISRIFHSASKSAQRLKYI----SPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR--- 772
            .:...| .|:..|:.::::    :|...:...|   .||::|..||:|..||   |...|..
  Rat   677 TVVIAF-KATVPARMVRWLMVSRAPNFIIPFCT---LIQIIICGIWLVTSPP---FIDQDTHAEL 734

  Fly   773 -EVILKCKIQDMSFLFSQLYNMILITICTI------YAIKTRKIPENFNESKFIGFTMYTTCIIW 830
             .:|:.|.:..     :..::.:|..:|::      .|..:|.:|:.|||:||:.|:|.....:|
  Rat   735 GHIIIVCNMGS-----TVAFHTVLGYLCSLALGSYTMAFLSRNLPDTFNEAKFLSFSMQVFFCVW 794

  Fly   831 LAFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHPDKN 881
            :.|:|:|..|.....|......|   |::|:||: .:::||.||::...:||
  Rat   795 ITFLPVYHSTKGKVMVAMEVFSI---LASSIALLGLIFAPKCYIILLRTEKN 843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	107/530 (20%)
		ANF_receptor	72..518	CDD:279440	97/477 (20%)
		NCD3G	557..604	CDD:284890	16/50 (32%)
		7tm_3	638..873	CDD:278433	70/249 (28%)
Vom2r37	XP_038947382.1	PBP1_pheromone_receptor	40..506	CDD:380588	106/533 (20%)
		NCD3G	514..567	CDD:400103	17/52 (33%)
		7tmC_V2R_pheromone	587..838	CDD:320410	75/266 (28%)
		TM helix 1	588..612	CDD:320410	7/24 (29%)
		TM helix 2	624..645	CDD:320410	7/20 (35%)
		TM helix 3	654..676	CDD:320410	7/21 (33%)
		TM helix 4	702..718	CDD:320410	4/18 (22%)
		TM helix 5	745..768	CDD:320410	2/27 (7%)
		TM helix 6	780..802	CDD:320410	7/21 (33%)
		TM helix 7	807..832	CDD:320410	6/27 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910