DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vom2r9

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001092935.1	Gene:	Vom2r9 / 685666	RGDID:	1591347	Length:	866	Species:	Rattus norvegicus

Alignment Length:	916	Identity:	209/916 - (22%)
Similarity:	380/916 - (41%)	Gaps:	156/916 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVH------EKGEGAPCGPKVYN-----------RGVQRLEAMLYAIDRVNNDPNI 90
            |::::|..||:|      :...|     .|.|           ...|.:.|:::||:.:|.:|::
  Rat    41 GNVVIGAFFPLHTFYTANKTAYG-----NVMNYYKDFYLKYKFNNYQFVLALVFAIEEINKNPHL 100

  Fly    91 LPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGG 155
            |..|::|.|:.:....:...|..:|.::....|.:  ..|.|        |.|..|.   ..:.|
  Rat   101 LSNISLGFHVYNVPYTEKNTLMSTLIWLTGQRNFM--PNYNC--------RMNRMSA---AALTG 152

  Fly   156 SYSSVSLQVANLLRLFHIPQV-------SPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILK 213
            :..:.|.|:..||:|:..|||       .|:.  ..|||:.:|....:..|.||..|:|:|.::.
  Rat   153 TSWATSAQIGTLLQLYKFPQVREIILTFGPSD--PILSDRGQFSSLYQMAPNDTTLSLAMVSLML 215

  Fly   214 NFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPS--AADDKVFDSIISKLQKKPNA 276
            :||||:|..:..:...|.:.:..|.:|.....:|:|:.|.:|.  .:....|...:.|:|:. .|
  Rat   216 HFNWSWVGLLLIDDHKGTHILSHLREEMDRSKICLALVEMIPVTWTSFSYNFWKNLKKIQES-LA 279

  Fly   277 RGVVLFTRAEDARRILQAAKRANLSQPF----HWIASDGWGKQQKLLEGLEDIAEGAITVELQSE 337
            ...:::...:..:.::.     ||.|..    .||.:..|...::....|.|...|::......|
  Rat   280 NVFIIYGDIDSLQGLMD-----NLGQQLITWKVWIMNSQWDSTKQADYFLLDSFHGSLIFSHHHE 339

  Fly   338 IIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSL------SVKPDTSNSANSTDNKIGVKA 396
            ...:|..::.::.|.....:|:..:.|...|||..:..      :.:|:.|.....|.    :..
  Rat   340 ESFEFSNFIRKVNPYKYPEDPYLPKLWYALFNCSFSKFDCQLLENCQPNASLELFPTT----IID 400

  Fly   397 KTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESV-- 459
            .:..::||.               :..:|||.|:.|..:...:|..||        ||:.|.:
  Rat   401 MSMSEESYN---------------IYTSVYAVAHTLQEMSLQQCQMQS--------HLKGEKMVF 442

  Fly   460 --WYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQ 522
              |.                       .:::|..:.    .|..:..:.:...:..|||||:...
  Rat   443 FPWQ-----------------------LHHFLRKIH----EGDHMSLEWKWRFIEEYDILNFWNF 480

  Fly   523 ENSSGYQYKVIGKWF------NGLQLNSETVVW-NKETEQPTSACSLPCEVGMIKKQQGD--TCC 578
            ....|.:.|| |.:.      ..|.|:...:.| .|.|:.|.|||...|..|..|..|..  .||
  Rat   481 PKGLGLKVKV-GTFSLDAPQGEQLSLSEHMIQWPTKFTQIPQSACYTSCWPGFRKATQKGRAVCC 544

  Fly   579 WICDSC--ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALT 641
            :.|..|  .......|...|..|....:|..:|.:|....:.::::|....::.:.||:...|||
  Rat   545 YDCIPCLDNEISNETDVDQCVKCPETHFPNTEKNNCLQKSMSFLEYNDNLGMVLITIALCFSALT 609

  Fly   642 SIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIY 706
            ..|:.:|.|..|||:|:|:.|.|||.||..::||:..:...|..|...:|::|:...|:.|::..
  Rat   610 LAVLGVFVKYRDTPIVKANNRTLSYILLMTLVVCFLCSLLFIGHPNTATCLMQQTTFGIVFTVAL 674

  Fly   707 SALLTKTNRISRIF-HSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFY--- 767
            |.:|.|...:...| .:......|...:|.....||....: ||:::..|::...||   |.
  Rat   675 STVLAKVITVVMAFKFTIPGRITRWLMVSRAPNYVIPICTL-IQIVLCGIYLGTSPP---FLDQD 735

  Fly   768 -YPDRREVILKC-KIQDMSFLFSQLYNMILITIC------TIYAIKTRKIPENFNESKFIGFTMY 824
             |.:...:::.| |..|:      :::.||..:|      .:.|..:|.:|:.|||||.:.|:|.
  Rat   736 PYSEHDHILIVCNKGSDV------VFHCILGYLCFLALGSCVMAFLSRNLPDTFNESKLLSFSMQ 794

  Fly   825 TTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNS 889
            ....:|:.|:|:|..|..  :|.......||..|::..|..:::||.||::..||:|......|:
  Rat   795 VFLCVWVTFLPVYHSTKG--KVMVAMQVSSILASSAGILGFIFAPKCYIILLRPDQNSLHHIRNT 857

  Fly   890 TVYRRS 895
            ...||:
  Rat   858 AYTRRN 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	108/544 (20%)
		ANF_receptor	72..518	CDD:279440	93/468 (20%)
		NCD3G	557..604	CDD:284890	14/50 (28%)
		7tm_3	638..873	CDD:278433	68/246 (28%)
Vom2r9	NP_001092935.1	PBP1_Pheromone_receptor	41..512	CDD:107360	109/551 (20%)
		ANF_receptor	85..455	CDD:279440	88/440 (20%)
		NCD3G	521..571	CDD:284890	14/49 (29%)
		7tm_3	607..841	CDD:278433	68/245 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910