Protein Alignment mGluR and Vom2r9

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001092935.1
• Gene: Vom2r9 / 685666
• RGDID: 1591347
• Length: 866
• Species: Rattus norvegicus
• Alignment Length: 916
• Identity: 209/916 - (22%)
• Similarity: 380/916 - (41%)
• Gaps: 156/916 - (17%)

  Fly    43 GDIILGGLFPVH------EKGEGAPCGPKVYN-----------RGVQRLEAMLYAIDRVNNDPNI 90
            |::::|..||:|      :...|     .|.|           ...|.:.|:::||:.:|.:|::
  Rat    41 GNVVIGAFFPLHTFYTANKTAYG-----NVMNYYKDFYLKYKFNNYQFVLALVFAIEEINKNPHL 100

  Fly    91 LPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGG 155
            |..|::|.|:.:....:...|..:|.::....|.:  ..|.|        |.|..|.   ..:.|
  Rat   101 LSNISLGFHVYNVPYTEKNTLMSTLIWLTGQRNFM--PNYNC--------RMNRMSA---AALTG 152

  Fly   156 SYSSVSLQVANLLRLFHIPQV-------SPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILK 213
            :..:.|.|:..||:|:..|||       .|:.  ..|||:.:|....:..|.||..|:|:|.::.
  Rat   153 TSWATSAQIGTLLQLYKFPQVREIILTFGPSD--PILSDRGQFSSLYQMAPNDTTLSLAMVSLML 215

  Fly   214 NFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPS--AADDKVFDSIISKLQKKPNA 276
            :||||:|..:..:...|.:.:..|.:|.....:|:|:.|.:|.  .:....|...:.|:|:. .|
  Rat   216 HFNWSWVGLLLIDDHKGTHILSHLREEMDRSKICLALVEMIPVTWTSFSYNFWKNLKKIQES-LA 279

  Fly   277 RGVVLFTRAEDARRILQAAKRANLSQPF----HWIASDGWGKQQKLLEGLEDIAEGAITVELQSE 337
            ...:::...:..:.::.     ||.|..    .||.:..|...::....|.|...|::......|
  Rat   280 NVFIIYGDIDSLQGLMD-----NLGQQLITWKVWIMNSQWDSTKQADYFLLDSFHGSLIFSHHHE 339

  Fly   338 IIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSL------SVKPDTSNSANSTDNKIGVKA 396
            ...:|..::.::.|.....:|:..:.|...|||..:..      :.:|:.|.....|.    :..
  Rat   340 ESFEFSNFIRKVNPYKYPEDPYLPKLWYALFNCSFSKFDCQLLENCQPNASLELFPTT----IID 400

  Fly   397 KTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESV-- 459
            .:..::||.               :..:|||.|:.|..:...:|..||        ||:.|.:
  Rat   401 MSMSEESYN---------------IYTSVYAVAHTLQEMSLQQCQMQS--------HLKGEKMVF 442

  Fly   460 --WYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQ 522
              |.                       .:::|..:.    .|..:..:.:...:..|||||:...
  Rat   443 FPWQ-----------------------LHHFLRKIH----EGDHMSLEWKWRFIEEYDILNFWNF 480

  Fly   523 ENSSGYQYKVIGKWF------NGLQLNSETVVW-NKETEQPTSACSLPCEVGMIKKQQGD--TCC 578
            ....|.:.|| |.:.      ..|.|:...:.| .|.|:.|.|||...|..|..|..|..  .||
  Rat   481 PKGLGLKVKV-GTFSLDAPQGEQLSLSEHMIQWPTKFTQIPQSACYTSCWPGFRKATQKGRAVCC 544

  Fly   579 WICDSC--ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALT 641
            :.|..|  .......|...|..|....:|..:|.:|....:.::::|....::.:.||:...|||
  Rat   545 YDCIPCLDNEISNETDVDQCVKCPETHFPNTEKNNCLQKSMSFLEYNDNLGMVLITIALCFSALT 609

  Fly   642 SIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIY 706
            ..|:.:|.|..|||:|:|:.|.|||.||..::||:..:...|..|...:|::|:...|:.|::..
  Rat   610 LAVLGVFVKYRDTPIVKANNRTLSYILLMTLVVCFLCSLLFIGHPNTATCLMQQTTFGIVFTVAL 674

  Fly   707 SALLTKTNRISRIF-HSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFY--- 767
            |.:|.|...:...| .:......|...:|.....||....: ||:::..|::...||   |.
  Rat   675 STVLAKVITVVMAFKFTIPGRITRWLMVSRAPNYVIPICTL-IQIVLCGIYLGTSPP---FLDQD 735

  Fly   768 -YPDRREVILKC-KIQDMSFLFSQLYNMILITIC------TIYAIKTRKIPENFNESKFIGFTMY 824
             |.:...:::.| |..|:      :::.||..:|      .:.|..:|.:|:.|||||.:.|:|.
  Rat   736 PYSEHDHILIVCNKGSDV------VFHCILGYLCFLALGSCVMAFLSRNLPDTFNESKLLSFSMQ 794

  Fly   825 TTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNS 889
            ....:|:.|:|:|..|..  :|.......||..|::..|..:::||.||::..||:|......|:
  Rat   795 VFLCVWVTFLPVYHSTKG--KVMVAMQVSSILASSAGILGFIFAPKCYIILLRPDQNSLHHIRNT 857

  Fly   890 TVYRRS 895
            ...||:
  Rat   858 AYTRRN 863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	108/544 (20%)
		NCD3G	556..605	CDD:462210	15/52 (29%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	72/262 (27%)
		TM helix 1	625..650	CDD:320600	7/24 (29%)
		TM helix 2	662..683	CDD:320600	8/20 (40%)
		TM helix 3	692..716	CDD:320600	6/23 (26%)
		TM helix 4	738..758	CDD:320600	5/19 (26%)
		TM helix 5	781..807	CDD:320600	5/31 (16%)
		TM helix 6	815..838	CDD:320600	8/22 (36%)
		TM helix 7	845..870	CDD:320600	5/24 (21%)
Vom2r9	NP_001092935.1	PBP1_pheromone_receptor	44..512	CDD:380588	108/548 (20%)
		NCD3G	520..573	CDD:462210	15/52 (29%)
		7tmC_V2R_pheromone	594..844	CDD:320410	72/261 (28%)
		TM helix 1	594..618	CDD:320410	7/23 (30%)
		TM helix 2	630..651	CDD:320410	8/20 (40%)
		TM helix 3	660..684	CDD:320410	6/23 (26%)
		TM helix 4	708..724	CDD:320410	4/16 (25%)
		TM helix 5	751..777	CDD:320410	5/31 (16%)
		TM helix 6	785..808	CDD:320410	8/22 (36%)
		TM helix 7	813..838	CDD:320410	5/24 (21%)