DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vom2r8

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001092934.1	Gene:	Vom2r8 / 685641	RGDID:	1591372	Length:	859	Species:	Rattus norvegicus

Alignment Length:	918	Identity:	199/918 - (21%)
Similarity:	361/918 - (39%)	Gaps:	196/918 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVHEKGEGAPCGPKV---------------YN-RGVQRLEAMLYAIDRVNNDPNIL 91
            ||:::|..||:|.    ...|.|:               || :..|.:.|:::||:.:|.:||:|
  Rat    40 GDVVIGAFFPIHT----YYTGNKIPHSFLPYYYVDNYLQYNFKNYQYILALIFAIEEINENPNLL 100

  Fly    92 PGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGS 156
            ..|::|....:....:...|..:..::.|.........|:|.       :|:.::     .:.|:
  Rat   101 SNISLGFDFYNVRFTEKDTLMNACIWLTAHREKYILPNYKCG-------KKHFTA-----ALTGT 153

  Fly   157 YSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVS 221
            ..:.|.|:..|.:||..||:|.......|||:.::....:..|..:..|:.:|.:|.:|.||:|.
  Rat   154 SWTTSAQMGTLFQLFKFPQLSFGPYDHILSDRNQYSSLYQMAPMASSLSLGIVSLLVHFRWSWVG 218

  Fly   222 TIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAE 286
            .|..:...|...:.....|...:.||||..:.:|:     .:.|..:|..|..:...|::.....
  Rat   219 LILPDDHKGNTILSDFRNEMERKGVCIAFLKMIPA-----TWMSHFNKFWKNMDETNVIIIYGDI 278

  Fly   287 DARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGL-EDIAEGAIT-----VELQSEIIAD---- 341
            |:                              |||| .:|.:..:|     :.::..:|||
  Rat   279 DS------------------------------LEGLMRNIGQRLLTWKVWVMNIEPHVIADYFML 313

  Fly   342 ------------------FDRYMMQLTPETNQRNPWFAEYWEDTFNCVLT--------------S 374
                              |..::..:.|.....:.:..:.|...|.|..:              |
  Rat   314 DSFHGSLIFTHHYTERIEFTNFVQTVNPYKYPEDIYLPKLWYLFFKCSFSDIDCQLLNNCQFNAS 378

  Fly   375 LSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDR 439
            |.:.|......:.:|..|.                           :.:||||.|::||.:...:
  Rat   379 LDILPRHIFDVSMSDESIS---------------------------IYNAVYAVAHSLHEMRLQQ 416

  Fly   440 CNTQSDQTTETRKHLQSESV---WYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSE 501
            ...|..:..|.......:.:   .|..:|      ...|..:.|.::.:|
  Rat   417 VQMQPYENGEEIMFFPWQVISFLLYCNVS------ILIDQRSLDWRQKFN--------------- 460

  Fly   502 VKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNG------LQLNSETVVWNKE-TEQPTSA 559
                      ..|||:|.....|..|.:.|| |.:...      |.|..:.:.|.:| :|.|.|.
  Rat   461 ----------TEYDIINLWNLPNGLGRKVKV-GSFSTNAPQGHQLSLTEQIIQWPEEFSEIPRSV 514

  Fly   560 CSLPCEVGMIK-KQQGD-TCCWICDSCESFEY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYM 620
            ||..|..|..| ..:|. .||:.|..|...|.  ..|...|..|....:...:|..|....:.::
  Rat   515 CSESCGHGFRKLALEGKAVCCYKCTPCADNEISNETDVDQCLKCPESHYANTEKNHCLQKAVSFL 579

  Fly   621 KWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAK 685
            .:.....:...:||:....||:.||.:|.|..|||:|:|:.:.|||.||..:..|:..:...|.:
  Rat   580 AYQDPLGMSLASIALCLSTLTAFVIGIFVKYRDTPIVKANNQALSYILLITLTFCFLCSLTFIGQ 644

  Fly   686 PTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYI----SPQSQVVITTSLI 746
            |...:|::|:...||.|::..:.:|.|...:...| .|:...:.::::    :|...:.|.|
  Rat   645 PNKDTCIMQQITFGVVFTVALATVLAKAITVVIAF-KATFPGRMIRWLMKSRAPNYIIPICT--- 705

  Fly   747 AIQVLITMIWMVVEPPG-TRFYYPDRREVILKC-KIQDMSFLFSQLYNMILITICTIYAIKTRKI 809
            .|||.|..|||...||. .:.::.:...:|:.| |...::|..:..|...|.......|..:|.:
  Rat   706 LIQVFICGIWMATSPPFIDQDFHAEHGHIIIFCNKGSSVAFHCTLGYLCFLALGGYTMAFLSRTL 770

  Fly   810 PENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVC-LYSPKVYI 873
            |::||||||:..::.....:|:.|:|:|..|...:.|.|....|   |::|:||:. :::||.||
  Rat   771 PDSFNESKFLSLSLLVFFCVWITFLPVYHSTMGKFMVATEIFSI---LASSIALLSFIFAPKCYI 832

  Fly   874 LVFHPDKN 881
            ::|.|::|
  Rat   833 ILFRPNEN 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	101/565 (18%)
		ANF_receptor	72..518	CDD:279440	84/490 (17%)
		NCD3G	557..604	CDD:284890	15/50 (30%)
		7tm_3	638..873	CDD:278433	69/241 (29%)
Vom2r8	NP_001092934.1	PBP1_Pheromone_receptor	40..503	CDD:107360	102/572 (18%)
		NCD3G	512..563	CDD:284890	15/50 (30%)
		7tm_3	599..832	CDD:278433	69/239 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910