Protein Alignment mGluR and tas1r2.1

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001034920.1
• Gene: tas1r2.1 / 664691
• ZFINID: ZDB-GENE-070917-1
• Length: 825
• Species: Danio rerio
• Alignment Length: 884
• Identity: 203/884 - (22%)
• Similarity: 377/884 - (42%)
• Gaps: 148/884 - (16%)

  Fly    40 SLPGDIILGGLFPVHEKGEGAP-------------CGPKVYNRGVQRLEAMLYAIDRVNNDPNIL 91
            ||.||.:||||||:||..:..|             ..|.    |.|.|:.|.:|::.:||...:|
Zfish    29 SLEGDFLLGGLFPLHEIDQVTPVFTPETTECFRYTASPS----GFQMLQVMRFAVEEINNSSTLL 89

  Fly    92 PGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGS-SPQLRKNASSGPVFGVIGG 155
            |.:::|..:.|.|| :|......|.|:             ..:|| .|.:::......|..:.|.
Zfish    90 PNVSLGYELFDHCS-NTRNFGSLLSFI-------------SKNGSIKPNVKRINYQSDVIALTGP 140

  Fly   156 SYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYV 220
            ..|:.::.:|.|:.:..||.|:..:::..||:|.::..|.||||.:......::.:::.|.|::|
Zfish   141 YGSTRTISIAPLITMDLIPLVNYGASSSVLSNKLQYPSFVRTVPSNKDMINMIIHMIRWFGWNWV 205

  Fly   221 STIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK---PNARGVVLF 282
            :.:.|:.:|...|:...:.......:|:|..|::.       .|:..|:..||   .|...:|:|
Zfish   206 AFLGSKDAYSTDGLNLFNTYINNTGICVAYQERLN-------LDANYSQTLKKIDMLNINVIVVF 263

  Fly   283 TRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLE--GLEDIAEGAITVELQSEIIADFDRY 345
            ...:.|..|:..|...|:.... ||||:.|...|:|..  |:|.|          ..:|...||.
Zfish   264 AVPQYAVNIINTAIADNIRDKV-WIASETWSMNQQLPREPGVEKI----------GTVIGITDRL 317

  Fly   346 MMQLTPETNQRNPWFAEYWEDTFNCVLTSL-SVKPDTSNSANSTDNKIGVKAKTECDDSYRL-SE 408
            :..         |.|.|:       :|..: :...:.|....:|.|:       :||....| :|
Zfish   318 LTL---------PGFNEF-------ILKDMGTANVNASKFQTNTCNQ-------KCDYCPSLTAE 359

  Fly   409 KVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQAC 473
            .:..|..|.:..:..|:|..|:|||.:                            :..|||  .|
Zfish   360 DIINENPSFSFAIYAAMYTIAHALHKV----------------------------LQCDTK--GC 394

  Fly   474 PDMANYDGKEFYNNYLL--NVSFID--LAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIG 534
            |....::      .|:|  .:..:|  |.|.:||:|:..|....|.::.:...|||.  |::::|
Zfish   395 PKNTPFE------PYMLLGEMKKLDFPLNGRQVKYDKNYDPPISYAVVLWHTDENSP--QFEMVG 451

  Fly   535 KW-------FNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQG-DTCCWICDSCESFEYV- 590
            .:       |.   :::....|..:: .|.|.||:.|:.|..::.:| .:||:.|..|....||
Zfish   452 TYDTYPKTVFT---IDNSRFPWRNDS-IPFSNCSVECKPGFARQPEGFHSCCFTCKKCPRNSYVD 512

  Fly   591 --YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHD 653
              .|.:||..|....|......:|....:.|:::..:.::..|...:|.|.|...::.||..|.:
Zfish   513 YSQDPYTCFPCAVSDWSDEGSTACKTRAVVYLEFTEITSIAVMISVLFLIILLIGILGLFTYNFN 577

  Fly   654 TPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISR 718
            ||:||::|.::...:|..:.:...:.|....||:...|:::.......|::..|.|..::.:|..
Zfish   578 TPVVRSAGGDMCLLMLLCLTISSISVFFFFGKPSSVHCLVRNAIFAFFFTVCLSCLTVRSFQIIC 642

  Fly   719 IFHSASKSAQRLK--YISPQSQVVITTSLIAIQVLITMIWMVVEPP---GTRFYYPDRREVILKC 778
            :|..|:: ..||.  ::....|.:.......|.::..:||..|.|.   ...:.:.|  :.:|.|
Zfish   643 VFKMAAQ-FPRLHSLWVKHNGQWLFIAFSSFIHLISCVIWTTVSPDIPIADSWTFKD--QTLLMC 704

  Fly   779 K-IQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGN 842
            : :..::|......:..|..:|.:::...|.:|:|:||:|.|.|::....:.|:.:...|....:
Zfish   705 EMVNTITFTVVLFISWFLGFLCLVFSYMGRDLPKNYNEAKSITFSLILYYLSWIVYFTAYLSIKS 769

  Fly   843 SYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            .| :........|| |....|...:.||.||::|.|.||
Zfish   770 KY-IMLLNAMAQIS-SIYGILFSYFIPKSYIMIFQPQKN 806

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	122/533 (23%)
		NCD3G	556..605	CDD:462210	17/52 (33%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	56/256 (22%)
		TM helix 1	625..650	CDD:320600	6/24 (25%)
		TM helix 2	662..683	CDD:320600	2/20 (10%)
		TM helix 3	692..716	CDD:320600	3/23 (13%)
		TM helix 4	738..758	CDD:320600	4/19 (21%)
		TM helix 5	781..807	CDD:320600	3/25 (12%)
		TM helix 6	815..838	CDD:320600	5/22 (23%)
		TM helix 7	845..870	CDD:320600	4/24 (17%)
tas1r2.1	NP_001034920.1	PBP1_taste_receptor	28..478	CDD:380586	124/549 (23%)
		NCD3G	476..529	CDD:462210	17/52 (33%)
		7tm_GPCRs	549..801	CDD:475119	56/256 (22%)
		TM helix 1	550..574	CDD:410628	6/23 (26%)
		TM helix 2	586..607	CDD:410628	2/20 (10%)
		TM helix 3	616..638	CDD:410628	3/21 (14%)
		TM helix 4	665..681	CDD:410628	1/15 (7%)
		TM helix 5	708..731	CDD:410628	3/22 (14%)
		TM helix 6	743..765	CDD:410628	4/21 (19%)
		TM helix 7	770..795	CDD:410628	5/26 (19%)