DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and tas1r2.1

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001034920.1	Gene:	tas1r2.1 / 664691	ZFINID:	ZDB-GENE-070917-1	Length:	825	Species:	Danio rerio

Alignment Length:	884	Identity:	203/884 - (22%)
Similarity:	377/884 - (42%)	Gaps:	148/884 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SLPGDIILGGLFPVHEKGEGAP-------------CGPKVYNRGVQRLEAMLYAIDRVNNDPNIL 91
            ||.||.:||||||:||..:..|             ..|.    |.|.|:.|.:|::.:||...:|
Zfish    29 SLEGDFLLGGLFPLHEIDQVTPVFTPETTECFRYTASPS----GFQMLQVMRFAVEEINNSSTLL 89

  Fly    92 PGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGS-SPQLRKNASSGPVFGVIGG 155
            |.:::|..:.|.|| :|......|.|:             ..:|| .|.:::......|..:.|.
Zfish    90 PNVSLGYELFDHCS-NTRNFGSLLSFI-------------SKNGSIKPNVKRINYQSDVIALTGP 140

  Fly   156 SYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYV 220
            ..|:.::.:|.|:.:..||.|:..:::..||:|.::..|.||||.:......::.:::.|.|::|
Zfish   141 YGSTRTISIAPLITMDLIPLVNYGASSSVLSNKLQYPSFVRTVPSNKDMINMIIHMIRWFGWNWV 205

  Fly   221 STIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK---PNARGVVLF 282
            :.:.|:.:|...|:...:.......:|:|..|::.       .|:..|:..||   .|...:|:|
Zfish   206 AFLGSKDAYSTDGLNLFNTYINNTGICVAYQERLN-------LDANYSQTLKKIDMLNINVIVVF 263

  Fly   283 TRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLE--GLEDIAEGAITVELQSEIIADFDRY 345
            ...:.|..|:..|...|:.... ||||:.|...|:|..  |:|.|          ..:|...||.
Zfish   264 AVPQYAVNIINTAIADNIRDKV-WIASETWSMNQQLPREPGVEKI----------GTVIGITDRL 317

  Fly   346 MMQLTPETNQRNPWFAEYWEDTFNCVLTSL-SVKPDTSNSANSTDNKIGVKAKTECDDSYRL-SE 408
            :..         |.|.|:       :|..: :...:.|....:|.|:       :||....| :|
Zfish   318 LTL---------PGFNEF-------ILKDMGTANVNASKFQTNTCNQ-------KCDYCPSLTAE 359

  Fly   409 KVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQAC 473
            .:..|..|.:..:..|:|..|:|||.:                            :..|||  .|
Zfish   360 DIINENPSFSFAIYAAMYTIAHALHKV----------------------------LQCDTK--GC 394

  Fly   474 PDMANYDGKEFYNNYLL--NVSFID--LAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIG 534
            |....::      .|:|  .:..:|  |.|.:||:|:..|....|.::.:...|||.  |::::|
Zfish   395 PKNTPFE------PYMLLGEMKKLDFPLNGRQVKYDKNYDPPISYAVVLWHTDENSP--QFEMVG 451

  Fly   535 KW-------FNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQG-DTCCWICDSCESFEYV- 590
            .:       |.   :::....|..:: .|.|.||:.|:.|..::.:| .:||:.|..|....||
Zfish   452 TYDTYPKTVFT---IDNSRFPWRNDS-IPFSNCSVECKPGFARQPEGFHSCCFTCKKCPRNSYVD 512

  Fly   591 --YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHD 653
              .|.:||..|....|......:|....:.|:::..:.::..|...:|.|.|...::.||..|.:
Zfish   513 YSQDPYTCFPCAVSDWSDEGSTACKTRAVVYLEFTEITSIAVMISVLFLIILLIGILGLFTYNFN 577

  Fly   654 TPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISR 718
            ||:||::|.::...:|..:.:...:.|....||:...|:::.......|::..|.|..::.:|..
Zfish   578 TPVVRSAGGDMCLLMLLCLTISSISVFFFFGKPSSVHCLVRNAIFAFFFTVCLSCLTVRSFQIIC 642

  Fly   719 IFHSASKSAQRLK--YISPQSQVVITTSLIAIQVLITMIWMVVEPP---GTRFYYPDRREVILKC 778
            :|..|:: ..||.  ::....|.:.......|.::..:||..|.|.   ...:.:.|  :.:|.|
Zfish   643 VFKMAAQ-FPRLHSLWVKHNGQWLFIAFSSFIHLISCVIWTTVSPDIPIADSWTFKD--QTLLMC 704

  Fly   779 K-IQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGN 842
            : :..::|......:..|..:|.:::...|.:|:|:||:|.|.|::....:.|:.:...|....:
Zfish   705 EMVNTITFTVVLFISWFLGFLCLVFSYMGRDLPKNYNEAKSITFSLILYYLSWIVYFTAYLSIKS 769

  Fly   843 SYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            .| :........|| |....|...:.||.||::|.|.||
Zfish   770 KY-IMLLNAMAQIS-SIYGILFSYFIPKSYIMIFQPQKN 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	120/530 (23%)
		ANF_receptor	72..518	CDD:279440	101/457 (22%)
		NCD3G	557..604	CDD:284890	16/50 (32%)
		7tm_3	638..873	CDD:278433	52/240 (22%)
tas1r2.1	NP_001034920.1	PBP1_Taste_receptor	28..471	CDD:107358	122/541 (23%)
		ANF_receptor	70..437	CDD:279440	101/457 (22%)
		NCD3G	478..528	CDD:284890	16/49 (33%)
		7tm_3	574..798	CDD:278433	48/228 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000