Protein Alignment mGluR and tas1r2.2

DIOPT Version :9

• Sequence 1: NP_001259076.1
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001077325.1
• Gene: tas1r2.2 / 664686
• ZFINID: ZDB-GENE-070917-2
• Length: 823
• Species: Danio rerio
• Alignment Length: 884
• Identity: 209/884 - (23%)
• Similarity: 387/884 - (43%)
• Gaps: 144/884 - (16%)

  Fly    40 SLPGDIILGGLFPVHE--------KGEGAPCGPKVYNR-GVQRLEAMLYAIDRVNNDPNILPGIT 95
            ||.||.:||||||:||        ..|...|....::: |.|.|:.|.:|::.:||...:||.::
Zfish    23 SLKGDYLLGGLFPIHEGKPATHLFTPEAIECFRYTFSKSGYQMLQVMRFAVEEINNSTTLLPDVS 87

  Fly    96 IGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGS-SPQLRKNASSGPVFGVIGGSYSS 159
            :|..|.|.|| ||......|.|:             ..:|| .|:|:.|.....|..:.|...|:
Zfish    88 LGYEIFDHCS-DTKNFPSVLSFI-------------SKNGSIKPKLKLNNYEPEVIALTGPYGST 138

  Fly   160 VSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIH 224
            .::.:|.|:.:..||.|:..:::.:||:|..:..|.||||.:......::.|::.|.|::|:.:.
Zfish   139 TTITIAPLITMDLIPLVNYGASSYSLSNKLMYPSFVRTVPSNKDLIHMIIQIIQWFGWNWVAFLG 203

  Fly   225 SEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDAR 289
            .:..|.|.|:...:...:...:|:|..|    |...|...|:..::....|...:|:|...:.|.
Zfish   204 DQDDYSEDGLRLFNTFISNSGICLAYQE----ALSQKTNYSLTFEMIDMLNVNVIVVFAEQQYAS 264

  Fly   290 RILQAAKRANLSQPFHWIASDGWGKQQKLLE--GLEDIAEGAITVELQSEIIADFDRYMMQLTPE 352
            .|::|| .||..:...||||:.|...|:|..  |:|.|          ..:|...:|::..
Zfish   265 NIIKAA-IANDVRDKVWIASETWSMNQQLPREPGIEKI----------GTVIGITERFLSL---- 314

  Fly   353 TNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKT---ECDDSYRL-SEKVGYE 413
                 |.|.|:           :..:..:.:.|........||::|   :||....| :|::..|
Zfish   315 -----PGFNEF-----------IYKERRSVDDAGHNHGMGEVKSQTCNQDCDCCTLLTAEEIITE 363

  Fly   414 QESKTQFVVDAVYAFAYALHNLHNDRCNTQ-SDQTTETRKHLQSESVWYRKISTDTKSQACPDMA 477
            ..:.|..:..|:|..|:|||.:.  :|:.. .|:.|..:.::..|.:  :|:
Zfish   364 NPTFTFGIYSAIYTIAHALHKVL--QCDVNVCDKNTTAKPYMLLEQI--KKL------------- 411

  Fly   478 NYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFN---- 538
                     ::.||       ..:||:|..||....:.|:.:..:.:..  .:..:|.:..
Zfish   412 ---------DFPLN-------DRQVKYDANGDPTISFAIILWHTETDPP--HFDKVGMFDTYPEV 458

  Fly   539 GLQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGDTCCWICDSC--ESF-EYVYDEFTCKDC 599
            ...:|:..:.|:...  |.|.||..|:.|..:: .:..|||::|..|  .|: :|..|.:||..|
Zfish   459 TFTINNTLLPWHNNV--PFSNCSAECKEGFAREHDRFHTCCFLCKKCPRNSYVDYTRDPYTCFPC 521

  Fly   600 GPGLWPYADKLSCYALDIQYMKWNS------LFA---LIPMAIAIFGIALTSIVIVLFAKNHDTP 655
            ....|......:|....:.|::...      ||:   |:.:.||||         ||||.|::||
Zfish   522 AESEWSDEGSTACKNRSVAYLQLTEASSITVLFSATCLMTVLIAIF---------VLFACNYNTP 577

  Fly   656 LVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIF 720
            :||::|..:.:.:|..:::...:.|....:||...|:|:.......||:..|.:..::.:|..||
Zfish   578 VVRSAGGSMCFLMLACLIMSTVSVFFFFGEPTFEHCILRNVIFAYFFSVFLSCMAVRSFQIVCIF 642

  Fly   721 HSASK-SAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGT-RFYYPDRREVILKCKIQDM 783
            ..|:| .:....::....|.:.......|.::..:::|.|.||.. |.....:.::||.|:|.:
Zfish   643 KMAAKFPSMHSLWVKHNGQWLFVGFFSIINIVSCVLYMTVSPPKPFRDLVTFKDQLILSCEIGN- 706

  Fly   784 SFLFSQLYNMILIT------ICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGN 842
                :...:|::..      :|.:::...|.:|:|:||:|.|.|::....:.|:.:...|....:
Zfish   707 ----TVTISMVMFIAWFLGFLCLVFSYMGRDLPKNYNEAKSITFSLILYYLSWIVYFTTYLMLKS 767

  Fly   843 SYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            .| :|.......:| |....|...:.||.||::|.|.||
Zfish   768 KY-IQLVNAMTELS-SIYGILFSYFIPKSYIIIFQPHKN 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	118/519 (23%)
		ANF_receptor	72..518	CDD:279440	104/453 (23%)
		NCD3G	557..604	CDD:284890	16/50 (32%)
		7tm_3	638..873	CDD:278433	54/242 (22%)
tas1r2.2	NP_001077325.1	Periplasmic_Binding_Protein_Type_1	22..470	CDD:299141	121/530 (23%)
		ANF_receptor	64..438	CDD:279440	104/455 (23%)
		NCD3G	476..526	CDD:284890	16/49 (33%)
		7tm_3	560..796	CDD:278433	58/251 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000