Protein Alignment mGluR and Vmn2r33

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001098535.2
• Gene: Vmn2r33 / 624512
• MGIID: 3757694
• Length: 861
• Species: Mus musculus
• Alignment Length: 865
• Identity: 187/865 - (21%)
• Similarity: 358/865 - (41%)
• Gaps: 139/865 - (16%)

  Fly    76 AMLYAIDRVNNDPNILPGITIGV-HILDTCSRDT-----YALNQSLQFVRASLNNLDTSGYECAD 134
            |:.:|:|.:|.:|::||.:::.: :.|..|...|     |..::.        |......|.|
Mouse    77 ALAFAMDEINRNPDLLPNMSLIIRYTLGRCDGKTVIPTPYLFHKK--------NQSPIPNYFC-- 131

  Fly   135 GSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQV-----SPASTAKTLSDKTRFDLF 194
             :...:.....:||.:|        ||:.....|..|..|::     .|.|:  ..||..::...
Mouse   132 -NEETMCSFLLTGPNWG--------VSISFWKYLDSFLSPRILQLTYGPFSS--IFSDDEQYPYL 185

  Fly   195 ARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAAD 259
            .:..|.||..::|:|..:..|||:::..:..:...|...:..|.|:...:.:|.|..:.:  :.|
Mouse   186 YQMAPKDTSLALAMVSFILYFNWNWIGLVIPDDDQGNQFLLELKKQRENKEICFAFVKMI--SVD 248

  Fly   260 DKVFDSIISKLQKK---PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEG 321
            |..|:.......|:   .::..::::....|...::.......:.|.. ||.:..|.......:.
Mouse   249 DISFEHKTEMYYKQIVMSSSNVIIIYEETIDFIDLIFRMWEPPVLQRI-WITTKQWNFPTSKRDI 312

  Fly   322 LEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSN-SA 385
            ......|::|.......|:.|..::          ..||....:|.:       .|.|:... ..
Mouse   313 THGTFYGSLTFLPHHGGISGFKDFV----------QTWFHLRSKDLY-------LVMPEWKYFKY 360

  Fly   386 NSTDNKIGVKAKTECDDSY--RLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQS-DQT 447
            .|:.:|..:......|.|:  .:.:|........:..:.:||:|.|:|||.::..:.:.|: |..
Mouse   361 ESSASKCKILKNNSSDASFDWLMEQKFDMAFSESSHNIYNAVHAIAHALHEMNLQQVDNQAIDNG 425

  Fly   448 TETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLA 512
            .....|                   |..:         |::|..:.|.:..|::|...::.....
Mouse   426 KGASSH-------------------CLKV---------NSFLRKIHFTNPLGNKVIMKQRVIMQE 462

  Fly   513 RYDILNYQRQENSSGYQYKVIGK---WFN---GLQLNSETV-VWNKETEQPTSACSLPCEVGM-- 568
            .|||.::.......|.:.| :||   :|:   ...|..:.: |.....:.|:|.||.....|.
Mouse   463 EYDIFHFGNLSQHLGIKVK-LGKFSPYFSHGRNFHLYVDMLEVATGSRKMPSSVCSAEGSPGFRR 526

  Fly   569 IKKQQGDTCCWICDSCE----SFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALI 629
            :.|:....||:||..|.    |.|...|:  |.:|....:...::..|....:.::.:..   .:
Mouse   527 LWKEGMAACCFICSPCPENEISNETNMDQ--CVNCPEYQYANTEQNKCIQKGVTFLSYED---PL 586

  Fly   630 PMAIAIFGI---ALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSC 691
            .||:|:...   |.|::|:.:|.|:||||:|:|:.|.|||.||..::.|:..:|..|..|...:|
Mouse   587 GMALALMAFCFSAFTAVVLCVFVKHHDTPIVKANNRILSYILLISLMSCFLCSFFFIGHPNRATC 651

  Fly   692 VLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLK---------YISPQSQVVITTSLIA 747
            |||:...|:.|::..|.:|.||..:...| ..:...:||:         ||.|...:
Mouse   652 VLQQITFGIVFTVAVSTVLAKTVTVVLAF-KVTDPGRRLRNFLVSGTPNYIIPICSL-------- 707

  Fly   748 IQVLITMIWMVVEPPGTRFYYPDRR----EVILKCKIQDMSFLFSQLYNMILITICTI-YAIKTR 807
            :|.::..||:.|.||   |...|..    .:|:.|....::..:..|..:..:.:.:. .|...:
Mouse   708 LQCVLCAIWLEVSPP---FVDIDEHSQHGHIIIVCNKGSVTAFYCVLGYLACLALGSFSLAFLAK 769

  Fly   808 KIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVY 872
            .:|:.|||:||:.|:|.....:|:.|:|:|..|..  :|.......||..|::..|.|:::||:|
Mouse   770 NLPDTFNEAKFLTFSMLVFFSVWVTFLPVYHSTKG--KVMVAVEIFSILASSAGMLGCIFAPKIY 832

  Fly   873 ILVFHPDKN-VRKLTM-NST 890
            |::..||:| .:|:.: |||
Mouse   833 IILMRPDRNSTQKIKVRNST 852

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	86/489 (18%)
		NCD3G	556..605	CDD:462210	16/54 (30%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	75/267 (28%)
		TM helix 1	625..650	CDD:320600	7/27 (26%)
		TM helix 2	662..683	CDD:320600	8/20 (40%)
		TM helix 3	692..716	CDD:320600	9/23 (39%)
		TM helix 4	738..758	CDD:320600	3/19 (16%)
		TM helix 5	781..807	CDD:320600	2/26 (8%)
		TM helix 6	815..838	CDD:320600	8/22 (36%)
		TM helix 7	845..870	CDD:320600	6/24 (25%)
Vmn2r33	NP_001098535.2	PBP1_pheromone_receptor	43..503	CDD:380588	87/495 (18%)
		NCD3G	512..565	CDD:462210	16/54 (30%)
		7tmC_V2R_pheromone	585..836	CDD:320410	75/264 (28%)
		TM helix 1	585..610	CDD:320410	7/24 (29%)
		TM helix 2	622..643	CDD:320410	8/20 (40%)
		TM helix 3	652..676	CDD:320410	9/23 (39%)
		TM helix 4	700..716	CDD:320410	4/23 (17%)
		TM helix 5	743..769	CDD:320410	2/25 (8%)
		TM helix 6	777..800	CDD:320410	8/22 (36%)
		TM helix 7	805..830	CDD:320410	6/24 (25%)