Protein Alignment mGluR and Grm8

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_071538.1
• Gene: Grm8 / 60590
• RGDID: 619858
• Length: 908
• Species: Rattus norvegicus
• Alignment Length: 922
• Identity: 431/922 - (46%)
• Similarity: 562/922 - (60%)
• Gaps: 76/922 - (8%)

  Fly    31 THTQD-SVSVSLPGDIILGGLFPVHEKGE-GAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPG 93
            ||:|: :.|:.:.||||||||||||.||| |.|||.....:|:.||||||||||::|.||::|..
  Rat    31 THSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSN 95

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYS 158
            ||:||.||||||||||||.|||.||:|.:.. |.|..:||:|..|...|   ...:.||||.:.|
  Rat    96 ITLGVRILDTCSRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTK---PDKISGVIGAAAS 156

  Fly   159 SVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTI 223
            |||:.|||:||||.|||:|.||||..|||.||:|.|:|.||||::|:.|:|||:....|:||||:
  Rat   157 SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTL 221

  Fly   224 HSEGSYGEYGIEALHKEATE-RNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAED 287
            .|||:|||.|:||..:.:.| ..||||.::|:|.......|:.||.:|.:.||||.|::|...:|
  Rat   222 ASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDD 286

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPE 352
            .||||:|||:.|.|..|.||.||.||.:...:...|:|||||:|:..:...|..||||....|..
  Rat   287 IRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351

  Fly   353 TNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESK 417
            .|:||.||||:||:.|.|.|.|       ....||...|        |....|::....||||.|
  Rat   352 NNRRNVWFAEFWEENFGCKLGS-------HGKRNSHIKK--------CTGLERIARDSSYEQEGK 401

  Fly   418 TQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGK 482
            .|||:||||:.||||||:|.:||.....                          .||.|...|||
  Rat   402 VQFVIDAVYSMAYALHNMHKERCPGYIG--------------------------LCPRMVTIDGK 440

  Fly   483 EFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETV 547
            |.. .|:..|:|...||:.|.|:..||...||||..|  |.|:...:||:||.|.|.|.|..|.:
  Rat   441 ELL-GYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQY--QINNKSTEYKIIGHWTNQLHLKVEDM 502

  Fly   548 VW-NKETEQPTSACSLPCEVGMIKKQ-QGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKL 610
            .| |:|...|.|.|||||:.|..||. :|..|||.|:.||.:.|..||.:|:.|.....|..::.
  Rat   503 QWANREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNINRT 567

  Fly   611 SCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVC 675
            .|..:.|..::|:|.:|::|:.|||.||..|:.|||.|.:.:|||:||||||||||.||.||.:|
  Rat   568 GCQRIPIIKLEWHSPWAVVPVFIAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLC 632

  Fly   676 YCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVV 740
            |..||.:||.|....|..:|..:|:|....|:|||||||||.|||....||....|:|||.||:|
  Rat   633 YSITFLMIAAPDTIICSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLV 697

  Fly   741 ITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREV-------ILKCKIQDMSFLFSQLYNMILITI 798
            ||.|||::|:|...:|.||:||.|...|.::|.:       :|||.|.|:|.:.|..|:::|:..
  Rat   698 ITFSLISVQLLGVFVWFVVDPPHTIIDYGEQRTLDPENARGVLKCDISDLSLICSLGYSILLMVT 762

  Fly   799 CTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---VQTTTLCISISLSAS 860
            ||:||||||.:||.|||:|.|||||||||||||||:||:|||..|.|   :|||||.:|:|||||
  Rat   763 CTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSAS 827

  Fly   861 VALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSS-----GYSRTHAPGTSAL 920
            |:|..||.|||||::|||::||:|       .:||..||...|...|     |..|.:....|.|
  Rat   828 VSLGMLYMPKVYIIIFHPEQNVQK-------RKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSEL 885

  Fly   921 TGGAVGTNASSS 932
            . .::.||.||:
  Rat   886 C-ESLETNTSST 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	233/504 (46%)
		NCD3G	556..605	CDD:462210	22/49 (45%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	142/260 (55%)
		TM helix 1	625..650	CDD:320600	12/24 (50%)
		TM helix 2	662..683	CDD:320600	13/20 (65%)
		TM helix 3	692..716	CDD:320600	11/23 (48%)
		TM helix 4	738..758	CDD:320600	10/19 (53%)
		TM helix 5	781..807	CDD:320600	11/25 (44%)
		TM helix 6	815..838	CDD:320600	19/22 (86%)
		TM helix 7	845..870	CDD:320600	16/27 (59%)
Grm8	NP_071538.1	PBP1_mGluR_groupIII	40..504	CDD:380599	235/511 (46%)
		NCD3G	512..562	CDD:462210	22/49 (45%)
		7tmC_mGluR8	582..892	CDD:320570	158/317 (50%)
		TM helix 1	582..607	CDD:320570	12/24 (50%)
		TM helix 2	619..640	CDD:320570	13/20 (65%)
		TM helix 3	649..673	CDD:320570	11/23 (48%)
		TM helix 4	695..715	CDD:320570	10/19 (53%)
		TM helix 5	745..771	CDD:320570	11/25 (44%)
		TM helix 6	779..802	CDD:320570	19/22 (86%)
		TM helix 7	812..837	CDD:320570	15/24 (63%)