Protein Alignment mGluR and olfcs2

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001094425.1
• Gene: olfcs2 / 570726
• ZFINID: ZDB-GENE-060503-238
• Length: 856
• Species: Danio rerio
• Alignment Length: 897
• Identity: 248/897 - (27%)
• Similarity: 406/897 - (45%)
• Gaps: 117/897 - (13%)

  Fly    36 SVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYN-------------RGVQRLEAMLYAIDRVNND 87
            |.|:...||:|:||||||:.:   ||.....:.             |..:.|:.||:.::.:|.|
Zfish    30 SESLYKEGDVIIGGLFPVYNE---APVPNHAFTQIQNRSRCQGVDLRSYRWLKTMLFTVEEINRD 91

  Fly    88 PNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGV 152
            |.:||.|.:|..:.|||..::..|:.:|..:......:  |..||.  .:|::       ||  :
Zfish    92 PFLLPNIILGYLVADTCLAESTTLSAALAIMTGQEETV--SDTECI--VAPRV-------PV--I 143

  Fly   153 IGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNW 217
            :|.:.||.|:.||:.|.:|.||.||..::...|.|..||..|.||||.|.||:.|:..:|...:|
Zfish   144 VGDARSSASIGVADTLGVFDIPMVSYFASCACLGDNHRFHTFLRTVPSDAFQAKAMARLLHLLDW 208

  Fly   218 SYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLF 282
            ::|..:..:..||:.|::.|.||.....||:...|.:|.:...:.....:..:|.. .|..||.|
Zfish   209 TWVGVVAGDDEYGKSGVQLLLKELEHVGVCVDYLEFIPKSHSQRRIRRTVETIQSS-TAHVVVTF 272

  Fly   283 TRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLE-DIAEGAITVELQSEIIADFDRYM 346
            ..|.|...:.:.....|::.. .|||::.|....:.|:... .:..|.:...|....|.....|:
Zfish   273 AIAPDIEVLFKEVVVQNVTNR-QWIATEAWSTSVQFLDPASIPLLAGTLGFALHRADIEGLGAYL 336

  Fly   347 MQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVG 411
            .||.|......|:..:.||:.|.|     |:..|...|..          :.:|..|..:....|
Zfish   337 SQLNPAKQSNEPFVKDVWEEIFGC-----SLAQDWQPSFK----------RPKCTGSENVEIHGG 386

  Fly   412 -YEQESK---TQFVVDAVYAFAYALHNL---HNDRCNTQSDQTTETRKHLQSESVWYRKISTDTK 469
             |...|:   |..|..||||.|||:||:   ...|...::.|
Zfish   387 IYTDVSQLRVTYNVYKAVYAIAYAIHNMIACQPGRGPFENGQ----------------------- 428

  Fly   470 SQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIG 534
               |||:.....::.. :||..|:|....|..|.|:..|:..|.|||:|:...| |....:..:|
Zfish   429 ---CPDVNQIKPRQLL-HYLNAVNFTTPVGELVYFEDNGEPSASYDIMNWHVDE-SGAVNFVQVG 488

  Fly   535 KW--FNG----LQLNSETVVWNK--ETEQPTSACSLPCEVGMIKK-QQGDT-CCWICDSCESFEY 589
            ::  .||    |.:|.:.|||..  ..:.|.|.||:.|..|..|. |:|.. ||:.|..|.:.|.
Zfish   489 QFDAANGPGQELNINIKKVVWGGGWSDQVPVSVCSVSCLPGTRKSVQKGKAICCFDCLPCAAGEI 553

  Fly   590 --VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNH 652
              :.|...|..|....|...::..|....::::.......::...:::.|..||:.|:..|..:.
Zfish   554 SNLTDSTKCIRCPEKFWSNVERTKCVPKIVEFLSLQDTMGIVLTVLSVTGATLTTTVLATFFHHR 618

  Fly   653 DTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRIS 717
            |||||||:..|||:.||..:.:|:......|.:|...:|:|:....||.|.|..:.:|:||..:.
Zfish   619 DTPLVRANNSELSFMLLVSLTLCFLCALVFIGRPATWNCMLRHTLFGVSFVICIACILSKTVVVL 683

  Fly   718 RIFHSASKSAQRLKYISPQSQ---VVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR------- 772
            ..|.:....:..::|..|..|   :::.|   .:||:|.::|:::.||     .|..|
Zfish   684 VAFQATLPGSNLMQYFGPIQQRAGILVCT---MVQVVICLLWLLLAPP-----LPTERAGGEFGA 740

  Fly   773 EVILKCKIQD-MSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPI 836
            .|||:|.:.. :.|.....|..:|..:|.:.|...||:|::|||:|||.|:|...|.:|:.|||.
Zfish   741 RVILQCTVGSVVGFALVLGYIGLLAVVCFLLAFFARKLPDSFNEAKFITFSMLIFCTVWIVFVPA 805

  Fly   837 YFGTGNSYEVQTTTLCISISLSASVA-LVCLYSPKVYILVFHPDKNVRKLTM 887
            |..:...|.|......|   |::|.. |:|:::||.||::..|:||.:|..|
Zfish   806 YVSSPGKYTVAVEIFAI---LASSYGLLLCIFTPKCYIILLKPEKNTKKNMM 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	139/529 (26%)
		NCD3G	556..605	CDD:462210	17/52 (33%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	79/262 (30%)
		TM helix 1	625..650	CDD:320600	5/24 (21%)
		TM helix 2	662..683	CDD:320600	6/20 (30%)
		TM helix 3	692..716	CDD:320600	8/23 (35%)
		TM helix 4	738..758	CDD:320600	6/22 (27%)
		TM helix 5	781..807	CDD:320600	5/26 (19%)
		TM helix 6	815..838	CDD:320600	11/22 (50%)
		TM helix 7	845..870	CDD:320600	6/25 (24%)
olfcs2	NP_001094425.1	PBP1_CaSR	40..509	CDD:380587	139/529 (26%)
		NCD3G	518..571	CDD:462210	17/52 (33%)
		7tmC_V2R_pheromone	591..843	CDD:320410	79/262 (30%)
		TM helix 1	591..616	CDD:320410	5/24 (21%)
		TM helix 2	628..649	CDD:320410	6/20 (30%)
		TM helix 3	658..682	CDD:320410	8/23 (35%)
		TM helix 4	706..722	CDD:320410	4/18 (22%)
		TM helix 5	750..776	CDD:320410	5/25 (20%)
		TM helix 6	784..807	CDD:320410	11/22 (50%)
		TM helix 7	812..837	CDD:320410	7/27 (26%)