DRSC/TRiP Functional Genomics Resources

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Protein Alignment mGluR and grm8b

DIOPT Version :10

Sequence 1:NP_524639.2 Gene:mGluR / 43838 FlyBaseID:FBgn0019985 Length:976 Species:Drosophila melanogaster
Sequence 2:NP_001274468.1 Gene:grm8b / 569768 ZFINID:ZDB-GENE-110421-3 Length:907 Species:Danio rerio


Alignment Length:935 Identity:414/935 - (44%)
Similarity:553/935 - (59%) Gaps:93/935 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 SPSNTHTQDSVSVSLPGDIILGGLFPVHEKGE-GAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNI 90
            :|...|     |:.|.||||||||||||.:|| |||||.....:|:.||||||:|||.:|.||::
Zfish    32 APEYAH-----SIRLDGDIILGGLFPVHARGERGAPCGELKKEKGIHRLEAMLFAIDLINKDPDL 91

  Fly    91 LPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGG 155
            ||.:|:|..||||||||||||.|||.||:|.:.. |::...||.|..|..   |....:.||||.
Zfish    92 LPNVTLGARILDTCSRDTYALEQSLTFVQALIER-DSTDVRCASGEQPIF---AKPDKIIGVIGA 152

  Fly   156 SYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYV 220
            :.||||:.|||:||||.|||:|.||||..|||.||:|.|:|.||||::|:.|::||:....|:||
Zfish   153 AASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMLDIVTAMGWNYV 217

  Fly   221 STIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTR 284
            ||:.|||:|||.|:||..:.:.|. .||||.:.|:|.......||.||.:|.:.|:||.:|:|..
Zfish   218 STLASEGNYGESGVEAFVQISRETGGVCIAQSLKIPREPRPGEFDKIILRLLETPSARAIVMFAN 282

  Fly   285 AEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQL 349
            .:|.||:|.||||.|.:..|.|:.||.||.:...:...|.:||||||:..:...|..||||....
Zfish   283 EDDIRRVLDAAKRNNQTGHFLWVGSDSWGSKISPVVQQESVAEGAITILPKRASIEAFDRYFKSR 347

  Fly   350 TPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVG--- 411
            :...|:||.||||:||:.|.|.|.....:|.:.......                   ||||   
Zfish   348 SLSNNRRNVWFAEFWEENFGCKLGMHGKRPGSPRKCTGL-------------------EKVGRDS 393

  Fly   412 -YEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPD 475
             ||||.|.|||:|||||.|:|||.:|.|.|:....                          .||.
Zfish   394 TYEQEGKVQFVMDAVYAMAHALHRMHRDLCSGYPG--------------------------LCPR 432

  Fly   476 MANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGL 540
            |:|.||||.. .|:.||||...|.:.|.|:..||...||||..||....|:  :|::||.|.:.|
Zfish   433 MSNIDGKELL-GYIRNVSFNGSAKTLVVFNENGDAPGRYDIYQYQITNKST--EYRIIGHWTDQL 494

  Fly   541 QLNSETVVW-NKETEQPTSACSLPCEVGMIKK-QQGDTCCWICDSCESFEYVYDEFTCKDCGPGL 603
            .||...:.| :.:...|||.|||||::|..|| .:|..|||.|:.||.:.|...||||:.|...|
Zfish   495 HLNINAMQWASGDDVMPTSVCSLPCQMGERKKIVKGVPCCWHCERCEGYHYQASEFTCQICPYEL 559

  Fly   604 WPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTL 668
            .|..::..|..:.|..::|:|.:|::|:.|||.||..|:.|:|.|.:.:|||:|||||||:||.|
Zfish   560 RPDQNRTGCQPIPIIKLEWHSPWAVVPVFIAILGILATTFVVVTFVRYNDTPIVRASGREMSYVL 624

  Fly   669 LFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYI 733
            |.||.:||..||.:|..|.:..|..:|..:|:|....|:|||||||||.|||.....|....::|
Zfish   625 LTGIFLCYVITFPMIGAPGVAVCSFRRIFLGLGMCFSYAALLTKTNRIHRIFEQGKCSVAAPRFI 689

  Fly   734 SPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR-------EVILKCKIQDMSFLFSQLY 791
            ||.||:|||.|||::|::...:|.||:||.|...|.::|       ..:|||.|.|:|.:.|..|
Zfish   690 SPASQLVITFSLISVQLMGVFVWFVVDPPHTVVDYGEQRTQDPKNARGVLKCDISDLSLICSLGY 754

  Fly   792 NMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---VQTTTLCI 853
            :::|:..||:||||||.:||.|||:|.|||||||||||||||:||:|||..|.|   :||.||.:
Zfish   755 SILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSEERMYIQTATLTV 819

  Fly   854 SISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTS 918
            |:||||||:|..||.|||||::.||::||.|       .:||..|:...|..::..|:.    .|
Zfish   820 SLSLSASVSLGMLYMPKVYIIILHPEQNVPK-------RKRSFKAIVTAATMTNKLSQL----AS 873

  Fly   919 ALTGGAVGT-------NASSSTLPT 936
            ....|.|.|       |::.||..|
Zfish   874 ERPNGEVKTELCESVDNSAPSTKTT 898

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mGluRNP_524639.2 PBP1_mGluR_groupII 39..542 CDD:380598 225/508 (44%)
NCD3G 556..605 CDD:462210 25/49 (51%)
7tmC_mGluRs_group2_3 625..876 CDD:320600 135/260 (52%)
TM helix 1 625..650 CDD:320600 11/24 (46%)
TM helix 2 662..683 CDD:320600 12/20 (60%)
TM helix 3 692..716 CDD:320600 11/23 (48%)
TM helix 4 738..758 CDD:320600 9/19 (47%)
TM helix 5 781..807 CDD:320600 11/25 (44%)
TM helix 6 815..838 CDD:320600 19/22 (86%)
TM helix 7 845..870 CDD:320600 15/27 (56%)
grm8bNP_001274468.1 PBP1_mGluR_groupIII 39..503 CDD:380599 227/515 (44%)
NCD3G 511..561 CDD:462210 25/49 (51%)
7tm_GPCRs 581..907 CDD:475119 153/329 (47%)
TM helix 1 582..606 CDD:410628 11/23 (48%)
TM helix 2 618..639 CDD:410628 12/20 (60%)
TM helix 3 648..670 CDD:410628 9/21 (43%)
TM helix 4 696..712 CDD:410628 7/15 (47%)
TM helix 5 744..767 CDD:410628 8/22 (36%)
TM helix 6 779..801 CDD:410628 18/21 (86%)
TM helix 7 811..836 CDD:410628 14/24 (58%)

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