Protein Alignment mGluR and grm6a

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_021333966.1
• Gene: grm6a / 568484
• ZFINID: ZDB-GENE-060208-1
• Length: 908
• Species: Danio rerio
• Alignment Length: 968
• Identity: 419/968 - (43%)
• Similarity: 567/968 - (58%)
• Gaps: 111/968 - (11%)

  Fly    17 LSWSRVVDLKSPSNTHTQDSV-SVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQRLEAMLY 79
            |.|...|.|...|:.|..... |:.:||||.||||||||.:| .|.|||.....:|:.|||||||
Zfish    33 LLWILWVWLSPCSSVHQHSHPHSIKIPGDITLGGLFPVHSRGPAGVPCGEIKKEKGIHRLEAMLY 97

  Fly    80 AIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNA 144
            |:|::|:||.:||.||:|..||||||||||||.|||.||:|.:.. |||...|::|..|.:||..
Zfish    98 ALDQINSDPELLPNITLGARILDTCSRDTYALEQSLTFVQALIQK-DTSDIRCSNGEQPIIRKPE 161

  Fly   145 SSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALV 209
            .   |.||||.|.||||:.|||:||||.|||:|.||||..|||..|:|.|:|.||||::|:.|:|
Zfish   162 R---VVGVIGASGSSVSIMVANVLRLFEIPQISYASTAPELSDNNRYDFFSRVVPPDSYQAQAMV 223

  Fly   210 DILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKVFDSIISKLQKK 273
            ||:|...|:||||:.|||:|||.|::|..:.:.|. .:|||.:.|:|.......||.||.:|.:.
Zfish   224 DIVKAMGWNYVSTLASEGNYGESGVDAFVQISRETGGLCIAQSMKIPREPKPGEFDKIIKRLMET 288

  Fly   274 PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEI 338
            ||||||::|...:|.:::|:||:|:||:..|.::.||.||.:...:...||:||||:|:..:...
Zfish   289 PNARGVIIFAHEDDIKQVLEAARRSNLTGHFKFVGSDSWGAKSSPILDQEDVAEGAVTILPKRAS 353

  Fly   339 IADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDS 403
            |..||:|....:.|.|:||.||||:|||.|.|.||...:|.|..              |.:|...
Zfish   354 IDGFDQYFTTRSLENNRRNIWFAEFWEDDFRCKLTRPGIKIDPE--------------KKKCTGE 404

  Fly   404 YRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDT 468
            .|:|....||||.|.|||:|||||.|:||||:|.:.|                          ..
Zfish   405 ERISRDSHYEQEGKVQFVIDAVYAMAHALHNMHQELC--------------------------PG 443

  Fly   469 KSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVI 533
            .:..|..|...:|:... ||:..|:|...||:.|.|:..||...||||..|| ..|:|...|:||
Zfish   444 ATGVCDKMDPVEGRSLL-NYIRAVNFNGSAGTAVLFNENGDAPGRYDIFQYQ-MTNTSSPGYRVI 506

  Fly   534 GKWFNGLQLNSETVVWNKETEQ-PTSACSLPCEVGMIKKQ-QGDTCCWICDSCESFEYVYDEFTC 596
            |:|.|.|:||.|.:.|...:.| |.|.||.||..|..||. :|..|||.|:.|:.:::..|||.|
Zfish   507 GQWTNNLRLNVEEMQWTGGSRQIPDSVCSFPCRSGERKKMVKGVPCCWHCELCDGYQFQADEFNC 571

  Fly   597 KDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASG 661
            :.|...:.|..::.:|....|..::|:|.:|:||:.:||.||..|..:|:.|.:.:|||:|||:|
Zfish   572 EMCPFDMRPTLNRTACRPTPIIKLEWHSPWAVIPLFLAILGILATLFIIITFIRFNDTPIVRAAG 636

  Fly   662 RELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS 726
            |||||.||.||.:.|..||.:||:|....|..:|..:|:|.||.|||:|||||||.|||....||
Zfish   637 RELSYVLLTGIFLIYLITFLMIAEPGTVVCAFRRLLLGLGMSITYSAMLTKTNRIYRIFEQGKKS 701

  Fly   727 AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYY-------PDRREVILKCKIQDMS 784
            ....|:|||.||::||..||::||:...:|..|.||.|...|       |:....||||.:.|:|
Zfish   702 VTPPKFISPTSQLMITFVLISVQVVGVFVWFGVMPPHTTVDYEELRPPNPELARGILKCDMSDLS 766

  Fly   785 FLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---V 846
            .:....|:::|:..||:||:|:|.:||.|||:|.||||||||||||||||||:|||..|.|   :
Zfish   767 LICCLSYSIVLMVTCTVYAVKSRGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSTEKMFI 831

  Fly   847 QTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSR 911
            |||||.:|:||||||:|..||.||||:::|||::||:|       .:||..||.|.|..||..|
Zfish   832 QTTTLTVSMSLSASVSLGMLYIPKVYVIIFHPEQNVQK-------RKRSFKAVVQAATMSSRLS- 888

  Fly   912 THAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVGERVEP 969
                                                |.::..|.|||      .::||
Zfish   889 ------------------------------------QKSINEKQNGE------TKIEP 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	226/504 (45%)
		NCD3G	556..605	CDD:462210	20/49 (41%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	134/260 (52%)
		TM helix 1	625..650	CDD:320600	10/24 (42%)
		TM helix 2	662..683	CDD:320600	12/20 (60%)
		TM helix 3	692..716	CDD:320600	13/23 (57%)
		TM helix 4	738..758	CDD:320600	8/19 (42%)
		TM helix 5	781..807	CDD:320600	9/25 (36%)
		TM helix 6	815..838	CDD:320600	20/22 (91%)
		TM helix 7	845..870	CDD:320600	16/27 (59%)
grm6a	XP_021333966.1	PBP1_mGluR_groupIII	56..522	CDD:380599	229/511 (45%)
		NCD3G	530..580	CDD:462210	20/49 (41%)
		7tmC_mGluR_group3	600..870	CDD:320413	140/276 (51%)
		TM helix 1	600..625	CDD:320413	10/24 (42%)
		TM helix 2	637..658	CDD:320413	12/20 (60%)
		TM helix 3	667..691	CDD:320413	13/23 (57%)
		TM helix 4	713..733	CDD:320413	8/19 (42%)
		TM helix 5	763..789	CDD:320413	9/25 (36%)
		TM helix 6	797..820	CDD:320413	20/22 (91%)
		TM helix 7	830..855	CDD:320413	15/24 (63%)