DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm5a

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001315639.1	Gene:	grm5a / 568406	ZFINID:	ZDB-GENE-090821-9	Length:	1173	Species:	Danio rerio

Alignment Length:	1000	Identity:	363/1000 - (36%)
Similarity:	541/1000 - (54%)	Gaps:	119/1000 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GTILVVVMVLSWSRVVDLKSPSNTHTQD-SVSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNR-- 69
            |...::|.||..:|:...:..:.....: .|...:|||||:|.||.||.:    |...||:.|
Zfish     2 GGFHLLVFVLIGNRLGPTRILAEAQASERRVLAHIPGDIIIGALFSVHHQ----PPADKVHERKC 62

  Fly    70 -------GVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLD- 126
                   |:||:|||::.:||:|.||.|||.||:|..|.|:|.....||.||::|:|.:|.:.:
Zfish    63 GAVREQYGIQRVEAMMHTLDRINADPLILPNITLGCEIRDSCWHSAVALEQSIEFIRDTLVSAEE 127

  Fly   127 --------TSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAK 183
                    |.|     |.:|...|.    |:.|:||...|||::||.|||:||:|||::.::|:.
Zfish   128 EEGMAKCSTEG-----GGTPMKGKK----PIVGLIGPGSSSVAIQVQNLLQLFNIPQIAYSATSM 183

  Fly   184 TLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCI 248
            .||||:.:..|.|.||.|..|:.|:|||:|.:||:|||.||:||:|||.|:||....|.:..:||
Zfish   184 DLSDKSLYKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAIHTEGNYGESGMEAFKDMAAKEGICI 248

  Fly   249 AVAEKVPSAADDKVFDSIISKLQKK-PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGW 312
            |.::|:.|.|.::.||.::.||:.. |.||.|..|......|.||.|.:|..|...|..:.||||
Zfish   249 AHSDKIYSNAGEQSFDRLLDKLRSHLPKARVVACFCEGMTVRGILMAMRRRRLVGEFLLVGSDGW 313

  Fly   313 GKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSV 377
            ..:..:.:|.:..|.|.||::|||..:..||.|.:.|.|:||.|||||.|:|:..|.|   .|..
Zfish   314 ADRYDVTDGFQREAAGGITIKLQSAYVTWFDDYYLNLQPDTNMRNPWFPEFWQHRFQC---RLKG 375

  Fly   378 KPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNT 442
            .|..|...|.|..|             :.|.:..|.|::|..||::|:|:.|:.||.:....|..
Zfish   376 HPQESVKYNKTCTK-------------KESLRHQYAQDTKMGFVINAIYSMAFGLHAMQKSLCPG 427

  Fly   443 QSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQ 507
            .:.                          .|..|...||.:.. .:|:..:|..::|..|.||..
Zfish   428 YAG--------------------------LCEAMRPIDGGKLL-EFLMRTNFSGVSGEVVLFDEN 465

  Fly   508 GDGLARYDILNYQRQENSSGYQYKVIGKWFN-GLQLNSETVVWNKETEQPTSACSLPCEVGMIKK 571
            ||...||:|:|: :|.:...|.|..:|.|.| ||:::.|. :|...:....|.||.|||...||.
Zfish   466 GDSPGRYEIMNF-KQMSEEDYSYIHVGSWDNRGLKMDDEE-IWANSSAIIRSVCSDPCEKAQIKV 528

  Fly   572 -QQGD-TCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIA 634
             ::|: :|||.|..|:..|:|:||:||:.|..|.||..|...|..:.:||::|.....:..:..|
Zfish   529 IRKGEVSCCWTCTPCKENEFVFDEYTCRACELGSWPTDDLTGCERIPVQYLQWGDPEPIAAVVFA 593

  Fly   635 IFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIG 699
            ..|:..|..|.::|.:.||||:|::|.|||.:.:|.||.:.|..||.|||||.:..|.|||.|||
Zfish   594 CLGLLATIFVTLVFVRFHDTPVVKSSSRELCFIILAGICLGYLCTFCLIAKPHVAYCYLQRLGIG 658

  Fly   700 VGFSIIYSALLTKTNRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPP 762
            :..::.||||:||||||:||...:.|.  .::.:::|..:|:||...||.||:.|.:...::|||
Zfish   659 LSPAMSYSALVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILILIQLGIIVALFIMEPP 723

  Fly   763 GTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTC 827
            ...:.||..|||.|.|....:..:....||.:||..||.||.|||.:|.||||:|:|.|||||||
Zfish   724 QVIYDYPSIREVHLICNTTTLGVVAPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTC 788

  Fly   828 IIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVY 892
            |||||||||||  |::|::  .|:|.|:||||:.||.|::.|||||::..|::|||.....|||.
Zfish   789 IIWLAFVPIYF--GSNYKI--ITMCFSVSLSATTALCCMFVPKVYIMLAKPERNVRSAFTTSTVV 849

  Fly   893 R------RSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNV 951
            |      :||:|.::.:..::.:.|..:           ||:..||             :.:|..
Zfish   850 RMHVGDGKSASAASRSSSLANLFRRRPS-----------GTDTVSS-------------NGKTVT 890

  Fly   952 AHKTNGEFLPEVGERVEPICHIVNK 976
            ..:....:.|.:.:|:.  .||..|
Zfish   891 WAQNERSYRPNLWKRIS--IHIKKK 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	186/518 (36%)
		ANF_receptor	72..518	CDD:279440	163/455 (36%)
		NCD3G	557..604	CDD:284890	22/48 (46%)
		7tm_3	638..873	CDD:278433	113/236 (48%)
grm5a	NP_001315639.1	PBP1_mGluR_groupI	31..502	CDD:107369	188/527 (36%)
		ANF_receptor	72..478	CDD:279440	164/458 (36%)
		NCD3G	514..563	CDD:284890	22/48 (46%)
		7tm_3	597..830	CDD:278433	113/236 (48%)
		GluR_Homer-bdg	1123..1173	CDD:287563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820