DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm4

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_021332579.1	Gene:	grm4 / 567181	ZFINID:	ZDB-GENE-030131-5781	Length:	916	Species:	Danio rerio

Alignment Length:	964	Identity:	423/964 - (43%)
Similarity:	580/964 - (60%)	Gaps:	82/964 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGV 71
            |:.||.:.:...:.....|.|.:||..   |:.:.|||.||||||||.:| ||..||.....:|:
Zfish    18 GSALVFLYLFMTALAARTKGPGHTHLN---SIRIDGDISLGGLFPVHARGHEGKACGELKKEKGI 79

  Fly    72 QRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGS 136
            .||||||:|:||:|||..:||.||:|..|||||||||:||.|||.||:|.:.. |.:..:|..|.
Zfish    80 HRLEAMLFALDRINNDHELLPNITLGARILDTCSRDTHALEQSLTFVQALIEK-DGTDVKCQGGG 143

  Fly   137 SPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPD 201
            ||.:.|...   |.||||.|.||||:.|||:||||.|||||.||||..|||.||:|.|:|.||||
Zfish   144 SPIITKPER---VVGVIGASSSSVSIMVANILRLFKIPQVSYASTAPELSDNTRYDYFSRVVPPD 205

  Fly   202 TFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEA-LHKEATERNVCIAVAEKVPSAADDKVFDS 265
            |:|:.|:|||:::..|:||||:.|||:|||.|::| :.|...|.:|||:.:.|:|.....:.||.
Zfish   206 TYQAQAMVDIVRDMRWNYVSTVASEGNYGESGVDAFIQKSREEGSVCISQSVKIPREPKPEEFDK 270

  Fly   266 IISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAI 330
            ||.:|.:.||||.|::|...:|.||:|||||:||.:..|.|:.||.||.:...:...|::||||:
Zfish   271 IIKRLGENPNARVVIIFANEDDIRRLLQAAKKANQTGHFLWVGSDSWGSKISPVLNQEEMAEGAV 335

  Fly   331 TVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVK 395
            |:..:.:.|..||||....|.|.|:||.||||:||:.|||.|:..::|..:           |:|
Zfish   336 TILPKRQSIRGFDRYFTSRTLENNRRNIWFAEFWENNFNCKLSRHALKKGS-----------GIK 389

  Fly   396 AKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVW 460
               :|.:..|:.:...||||.|..||:|||||.|:||||:|.:.|
Zfish   390 ---KCTNQERIGKDSTYEQEGKVMFVIDAVYAMAHALHNMHKELC-------------------- 431

  Fly   461 YRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENS 525
                  ..|...|..|...||.:.... :.:|....:.|:.|:|:..||...||:|..||.:..:
Zfish   432 ------PGKVGLCSKMDPVDGAQLLKK-IRDVKIAGIGGNPVQFNENGDAPGRYEIYQYQIKNKT 489

  Fly   526 SGYQYKVIGKWFNGLQLNSETVVWNKETEQ-PTSACSLPCEVGMIKK-QQGDTCCWICDSCESFE 588
            :  :||:||.|.:.|.||...:.|.....| |||.||.||:.|..|| .:|.:|||.|:.|:.::
Zfish   490 A--EYKIIGHWTDQLYLNVRAMQWPGGGRQVPTSICSQPCKPGWRKKIVKGMSCCWHCERCDGYQ 552

  Fly   589 YVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHD 653
            |..|..|||.|...|.|..:...|..:.|..::|:|.:|:||:.|||.||..|..|:|.|.:.:|
Zfish   553 YQADLHTCKMCRFDLRPNKNHTGCQPIPIVKLEWSSPWAVIPVLIAILGIIATLFVVVTFIRYND 617

  Fly   654 TPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISR 718
            ||:|:||||||||.||.||.:||..||.:|:.|.:|.|.|:|..:|:|.||.|:|||||||||.|
Zfish   618 TPIVKASGRELSYVLLTGIFLCYATTFLMISTPDVGICSLRRIFLGLGMSISYAALLTKTNRIYR 682

  Fly   719 IFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREV-------IL 776
            ||.....:....::|||.||::||.|||::|:|...||..|:|......|.|:|.:       :|
Zfish   683 IFEQGKMTVSAPRFISPASQLIITFSLISVQLLGVCIWFAVDPSQALIDYEDQRTIDPEMARGVL 747

  Fly   777 KCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTG 841
            ||.|.|:|.:....|:|:|:..||:||||||.:||.|||:|.|||||||||||||||:||:|||.
Zfish   748 KCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTS 812

  Fly   842 NSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGA 903
            .|.|   :|||||.||:||||||:|..||.||||:::|||::||.|   .||   ||..||...|
Zfish   813 QSTEKMYIQTTTLTISVSLSASVSLGMLYMPKVYVVLFHPEQNVAK---RST---RSLKAVVTAA 871

  Fly   904 PTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQN-SPHLDEASAQTNVAHKTN 956
            ..|:.::    |..|....|...:....: |.||. ||      .||.:::..:
Zfish   872 TMSNKFN----PKASLRPNGEAKSELCEN-LETQGLSP------KQTYISYSNH 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	220/500 (44%)
		ANF_receptor	72..518	CDD:279440	195/446 (44%)
		NCD3G	557..604	CDD:284890	21/47 (45%)
		7tm_3	638..873	CDD:278433	131/244 (54%)
grm4	XP_021332579.1	Periplasmic_Binding_Protein_Type_1	50..511	CDD:324556	222/507 (44%)
		NCD3G	520..569	CDD:311495	22/48 (46%)
		7tmC_mGluR4	589..916	CDD:320568	163/343 (48%)
		TM helix 1	589..614	CDD:320568	12/24 (50%)
		TM helix 2	626..647	CDD:320568	13/20 (65%)
		TM helix 3	656..680	CDD:320568	14/23 (61%)
		TM helix 4	702..722	CDD:320568	10/19 (53%)
		TM helix 5	752..778	CDD:320568	11/25 (44%)
		TM helix 6	786..809	CDD:320568	19/22 (86%)
		TM helix 7	819..844	CDD:320568	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	46	1.000	Domainoid score	I12113
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920