Protein Alignment mGluR and grm6b

DIOPT Version :9

• Sequence 1: NP_001259076.1
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001073489.1
• Gene: grm6b / 565450
• ZFINID: ZDB-GENE-021120-2
• Length: 905
• Species: Danio rerio
• Alignment Length: 980
• Identity: 419/980 - (42%)
• Similarity: 577/980 - (58%)
• Gaps: 113/980 - (11%)

  Fly     4 KNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVY 67
            |.:.|:::.::.:|:.....:.::.| :.||.. |:.:.|||.||||||||.:| .|.|||....
Zfish    21 KPHVGSLIHIMWILTMGFTPESQAAS-SDTQPH-SIKIEGDITLGGLFPVHSRGPAGIPCGEVKK 83

  Fly    68 NRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYEC 132
            .:|:.|:||||||:|::|:||::||.||:|..||||||||||||.|||.||:|.:.. |.|...|
Zfish    84 EKGIHRMEAMLYALDQINSDPDLLPNITLGARILDTCSRDTYALEQSLTFVQALIQK-DNSDVRC 147

  Fly   133 ADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFART 197
            ::|..|.:.|...   |.||||.|.||||:.|||:||||.|||:|.||||..|||..|:|.|:|.
Zfish   148 SNGEPPIIPKPER---VVGVIGASASSVSIMVANVLRLFAIPQISYASTAPELSDNNRYDFFSRV 209

  Fly   198 VPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDK 261
            ||||:||:.|:|||:|...|:||||:.|||:|||.|::|..:.:.|. .:|||.|.|:|......
Zfish   210 VPPDSFQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFIQISREAGGLCIAQAIKIPREPRPG 274

  Fly   262 VFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIA 326
            .||.||.:|.:..|||||::|...:|.:|:|:|||||||:..|.::.||.||.:...:...||:|
Zfish   275 EFDKIIKRLMETSNARGVIIFANEDDIKRVLEAAKRANLTGHFLFVGSDSWGAKISPILNQEDVA 339

  Fly   327 EGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNK 391
            |||:|:..:...|..||:|....:.|.|:||.||||:|||.|.|.||...::.|.
Zfish   340 EGAVTILPKRASIEGFDQYFTTRSLENNRRNIWFAEFWEDDFKCKLTRPGIRGDG---------- 394

  Fly   392 IGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQS 456
             |::   :|....|:....|||||.|.|||:|||||.|:|||::|.|.|
Zfish   395 -GLR---KCTGEERIGRDSGYEQEGKVQFVIDAVYAMAHALHSMHIDLC---------------- 439

  Fly   457 ESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQR 521
                      ......|..|...||:... .|:..|:|...||:.|.|:..||...||||..||
Zfish   440 ----------PGSMGVCDKMDPVDGRMLL-TYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQ- 492

  Fly   522 QENSSGYQYKVIGKWFNGLQLNSETVVWN-KETEQPTSACSLPCEVGMIKKQ-QGDTCCWICDSC 584
            ..|::...||:||:|.|.|:|::|.:.|: .|...|.|.||.|||.|..|:. :|..|||.|:.|
Zfish   493 LSNTTNPGYKLIGQWTNHLRLSAEDMQWSGGEKLVPDSVCSFPCESGERKRMVKGVPCCWHCELC 557

  Fly   585 ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFA 649
            :.::::.|||.|..|...:.|..::.:|....|..::|:|.:|:||:.:|:.||..|:.||..|.
Zfish   558 DGYQFLLDEFNCDMCPFDMRPTPNRTACRPTPIIKLEWSSPWAIIPVFLAVLGILATTGVIATFI 622

  Fly   650 KNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTN 714
            :.:|||:||||||||||.||.||.:.|..||.:||:|....|..:|..:|:|..|.|||:|||||
Zfish   623 RFNDTPIVRASGRELSYVLLTGIFLIYLITFLMIAEPGTVVCAFRRLLLGLGMCISYSAMLTKTN 687

  Fly   715 RISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYY-------PDRR 772
            ||.|||....||....|:|||.||::||..||::|:|...||..|.||.|...:       |:..
Zfish   688 RIYRIFEQGKKSVTPPKFISPTSQLIITFILISVQLLGIFIWFGVVPPHTNVDFDELRPPNPEFA 752

  Fly   773 EVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIY 837
            ..||||.:.|:|.:....|:|.|:..||:||||:|.:||.|||:|.||||||||||||||||||:
Zfish   753 RGILKCDMSDLSLIGCLSYSMGLMVTCTVYAIKSRGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 817

  Fly   838 FGTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAV 899
            |||..|.|   :|||||.:|:||||:|:|..||.||||:::|||::||:|       .:||..||
Zfish   818 FGTSQSTEKMFIQTTTLTVSMSLSATVSLGMLYIPKVYVIIFHPEQNVQK-------RKRSFKAV 875

  Fly   900 AQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVG 964
            ||.|..|:                                 ||.:.|:.     |.|||
Zfish   876 AQAATVST---------------------------------HLSQKSSD-----KQNGE------ 896

  Fly   965 ERVEP 969
            .:|||
Zfish   897 TKVEP 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	224/500 (45%)
		ANF_receptor	72..518	CDD:279440	197/446 (44%)
		NCD3G	557..604	CDD:284890	19/47 (40%)
		7tm_3	638..873	CDD:278433	129/244 (53%)
grm6b	NP_001073489.1	PBP1_mGluR_groupIII	58..520	CDD:107371	226/507 (45%)
		ANF_receptor	88..492	CDD:279440	197/448 (44%)
		NCD3G	530..576	CDD:284890	19/45 (42%)
		7tm_3	611..856	CDD:278433	129/244 (53%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920