Protein Alignment mGluR and grm6b

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001073489.2
• Gene: grm6b / 565450
• ZFINID: ZDB-GENE-021120-2
• Length: 909
• Species: Danio rerio
• Alignment Length: 980
• Identity: 419/980 - (42%)
• Similarity: 577/980 - (58%)
• Gaps: 113/980 - (11%)

  Fly     4 KNNNGTILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVY 67
            |.:.|:::.::.:|:.....:.::.| :.||.. |:.:.|||.||||||||.:| .|.|||....
Zfish    25 KPHVGSLIHIMWILTMGFTPESQAAS-SDTQPH-SIKIEGDITLGGLFPVHSRGPAGIPCGEVKK 87

  Fly    68 NRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYEC 132
            .:|:.|:||||||:|::|:||::||.||:|..||||||||||||.|||.||:|.:.. |.|...|
Zfish    88 EKGIHRMEAMLYALDQINSDPDLLPNITLGARILDTCSRDTYALEQSLTFVQALIQK-DNSDVRC 151

  Fly   133 ADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFART 197
            ::|..|.:.|...   |.||||.|.||||:.|||:||||.|||:|.||||..|||..|:|.|:|.
Zfish   152 SNGEPPIIPKPER---VVGVIGASASSVSIMVANVLRLFAIPQISYASTAPELSDNNRYDFFSRV 213

  Fly   198 VPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDK 261
            ||||:||:.|:|||:|...|:||||:.|||:|||.|::|..:.:.|. .:|||.|.|:|......
Zfish   214 VPPDSFQAQAMVDIVKAMGWNYVSTLASEGNYGESGVDAFIQISREAGGLCIAQAIKIPREPRPG 278

  Fly   262 VFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIA 326
            .||.||.:|.:..|||||::|...:|.:|:|:|||||||:..|.::.||.||.:...:...||:|
Zfish   279 EFDKIIKRLMETSNARGVIIFANEDDIKRVLEAAKRANLTGHFLFVGSDSWGAKISPILNQEDVA 343

  Fly   327 EGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNK 391
            |||:|:..:...|..||:|....:.|.|:||.||||:|||.|.|.||...::.|.
Zfish   344 EGAVTILPKRASIEGFDQYFTTRSLENNRRNIWFAEFWEDDFKCKLTRPGIRGDG---------- 398

  Fly   392 IGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQS 456
             |::   :|....|:....|||||.|.|||:|||||.|:|||::|.|.|
Zfish   399 -GLR---KCTGEERIGRDSGYEQEGKVQFVIDAVYAMAHALHSMHIDLC---------------- 443

  Fly   457 ESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQR 521
                      ......|..|...||:... .|:..|:|...||:.|.|:..||...||||..||
Zfish   444 ----------PGSMGVCDKMDPVDGRMLL-TYIRAVNFNGSAGTGVMFNENGDAPGRYDIFQYQ- 496

  Fly   522 QENSSGYQYKVIGKWFNGLQLNSETVVWN-KETEQPTSACSLPCEVGMIKKQ-QGDTCCWICDSC 584
            ..|::...||:||:|.|.|:|::|.:.|: .|...|.|.||.|||.|..|:. :|..|||.|:.|
Zfish   497 LSNTTNPGYKLIGQWTNHLRLSAEDMQWSGGEKLVPDSVCSFPCESGERKRMVKGVPCCWHCELC 561

  Fly   585 ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFA 649
            :.::::.|||.|..|...:.|..::.:|....|..::|:|.:|:||:.:|:.||..|:.||..|.
Zfish   562 DGYQFLLDEFNCDMCPFDMRPTPNRTACRPTPIIKLEWSSPWAIIPVFLAVLGILATTGVIATFI 626

  Fly   650 KNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTN 714
            :.:|||:||||||||||.||.||.:.|..||.:||:|....|..:|..:|:|..|.|||:|||||
Zfish   627 RFNDTPIVRASGRELSYVLLTGIFLIYLITFLMIAEPGTVVCAFRRLLLGLGMCISYSAMLTKTN 691

  Fly   715 RISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYY-------PDRR 772
            ||.|||....||....|:|||.||::||..||::|:|...||..|.||.|...:       |:..
Zfish   692 RIYRIFEQGKKSVTPPKFISPTSQLIITFILISVQLLGIFIWFGVVPPHTNVDFDELRPPNPEFA 756

  Fly   773 EVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIY 837
            ..||||.:.|:|.:....|:|.|:..||:||||:|.:||.|||:|.||||||||||||||||||:
Zfish   757 RGILKCDMSDLSLIGCLSYSMGLMVTCTVYAIKSRGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 821

  Fly   838 FGTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAV 899
            |||..|.|   :|||||.:|:||||:|:|..||.||||:::|||::||:|       .:||..||
Zfish   822 FGTSQSTEKMFIQTTTLTVSMSLSATVSLGMLYIPKVYVIIFHPEQNVQK-------RKRSFKAV 879

  Fly   900 AQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVG 964
            ||.|..|:                                 ||.:.|:.     |.|||
Zfish   880 AQAATVST---------------------------------HLSQKSSD-----KQNGE------ 900

  Fly   965 ERVEP 969
            .:|||
Zfish   901 TKVEP 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	224/504 (44%)
		NCD3G	556..605	CDD:462210	20/49 (41%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	135/260 (52%)
		TM helix 1	625..650	CDD:320600	10/24 (42%)
		TM helix 2	662..683	CDD:320600	12/20 (60%)
		TM helix 3	692..716	CDD:320600	12/23 (52%)
		TM helix 4	738..758	CDD:320600	9/19 (47%)
		TM helix 5	781..807	CDD:320600	11/25 (44%)
		TM helix 6	815..838	CDD:320600	20/22 (91%)
		TM helix 7	845..870	CDD:320600	15/27 (56%)
grm6b	NP_001073489.2	PBP1_mGluR_groupIII	58..524	CDD:380599	226/511 (44%)
		NCD3G	532..582	CDD:462210	20/49 (41%)
		7tmC_mGluR_group3	602..872	CDD:320413	141/276 (51%)
		TM helix 1	602..627	CDD:320413	10/24 (42%)
		TM helix 2	639..660	CDD:320413	12/20 (60%)
		TM helix 3	669..693	CDD:320413	12/23 (52%)
		TM helix 4	715..735	CDD:320413	9/19 (47%)
		TM helix 5	765..791	CDD:320413	11/25 (44%)
		TM helix 6	799..822	CDD:320413	20/22 (91%)
		TM helix 7	832..857	CDD:320413	14/24 (58%)