Protein Alignment mGluR and Vmn2r1

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_064302.2
• Gene: Vmn2r1 / 56544
• MGIID: 3645892
• Length: 912
• Species: Mus musculus
• Alignment Length: 970
• Identity: 249/970 - (25%)
• Similarity: 431/970 - (44%)
• Gaps: 142/970 - (14%)

  Fly    20 SRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEK----GEG--APCGP--KVYN-RGVQRLE 75
            |..||.|:.|               :::.||||:|.:    .|.  .|..|  :.:| ||.:.::
Mouse    40 SGYVDAKNHS---------------LVIAGLFPIHSRIIPVDEAILEPVSPMCEGFNFRGFRWMK 89

  Fly    76 AMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQL 140
            .|::.|..:|...:|||..|:|..|.|:|...:.|:..||.|:         :|.|   ...|..
Mouse    90 TMIHTIKEINERKDILPNHTLGYQIFDSCYTISKAMESSLVFL---------TGQE---EFKPNF 142

  Fly   141 RKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQS 205
            | |::...:..::|...||:|:..:.:|.|:::|||...|:...||||.:|..:.|.:|.|..||
Mouse   143 R-NSTGSTLAALVGSGGSSLSVAASRILGLYYMPQVGYTSSCSILSDKFQFPSYLRVLPSDNLQS 206

  Fly   206 VALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKL 270
            .|:|:::|:|.|.:|..|.::..||:||::...::....|:|:|.:|.:|....::.....: |.
Mouse   207 EAIVNLIKHFGWVWVGAIAADDDYGKYGVKTFKEKMESANLCVAFSETIPKVYSNEKMQKAV-KA 270

  Fly   271 QKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAE-------- 327
            .|...|:.:||:|...|....:......|::.. .|||::.|     :...|  ||:
Mouse   271 VKTSTAKVIVLYTSDIDLSLFVLEMIHHNITDR-TWIATEAW-----ITSAL--IAKPEYFPYFG 327

  Fly   328 GAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANST--DN 390
            |.|.......:|.....::..:.|..:..:....|:|:..|||...:.||..:..:..|.|  ::
Mouse   328 GTIGFATPRSVIPGLKEFLYDVHPNKDPNDVLTIEFWQTAFNCTWPNSSVPYNVDHRVNMTGKED 392

  Fly   391 KIGVKAKTECDDSYRLSE-KVGYEQESK---TQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETR 451
            ::...:...|....:|.: |..|...|:   |..|..||||.|:.|.  |..||  |..|
Mouse   393 RLYDMSDQLCTGEEKLEDLKNTYLDTSQLRITNNVKQAVYAIAHGLD--HLSRC--QEGQ----- 448

  Fly   452 KHLQSESVWYRKISTDTKSQACPDMANYDGKEFYN--NYLLNVSFIDLAGSEVKFDRQGD-GLAR 513
                         .....:|.|..:..:|   |:.  .|:..:.|.......|..|..|| ....
Mouse   449 -------------GPFGSNQQCAYIPTFD---FWQLMYYMKEIKFKSHEDKWVILDDNGDLKNGH 497

  Fly   514 YDILNYQRQENSSGYQYKVIGKWFNGLQLNSE-------TVVWNKE-TEQPTSACSLPCEVGMIK 570
            ||:||:...:... ..:..:|: ||....|.|       |:.||.| :.:|.|.|:..|..|..|
Mouse   498 YDVLNWHLDDEGE-ISFVTVGR-FNFRSTNFELVIPTNSTIFWNTESSRRPDSFCTQVCPPGTRK 560

  Fly   571 --KQQGDTCCWICDSCESFEYVYD---EFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIP 630
              :|....||:.|..|.. .||.:   :..|..||...|..|:|..|....::::.:........
Mouse   561 GIRQGQPICCFDCIPCAD-GYVSEKPGQRECDPCGEDDWSNAEKSKCVPKLVEFLAYEEALGFTL 624

  Fly   631 MAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQR 695
            :.::|||..:...|.|::..:..||||:|:.||||:.:...:::...::...|.||...||:.::
Mouse   625 VILSIFGALVLLAVTVVYVIHRHTPLVKANDRELSFLIQMSLVITVLSSLLFIGKPCNWSCMARQ 689

  Fly   696 FGIGVGFSIIYSALLTKTNRISRIF-HSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVV 759
            ..:.:||.:..|::|.||  ||..| :..|.|..||..:.|..:.:|....:..::.|...::|:
Mouse   690 ITLALGFCLCLSSILGKT--ISLFFAYRISVSKTRLISMHPIFRKLIVLICVVGEIGICAAYLVL 752

  Fly   760 EPPGTRFYYP---DRREVILKCKIQDMSFLFSQL-YNMILITICTIYAIKTRKIPENFNESKFIG 820
            |||  |.:..   ...::|.:|....:.||.|.. ::::|..:|.:.....|::|:|:.|.|.|.
Mouse   753 EPP--RMFKNIEIQNVKIIFECNEGSIEFLCSIFGFDVLLALLCFLTTFVARQLPDNYYEGKCIT 815

  Fly   821 FTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFHPDKNVRK 884
            |.|....|:|::|||.|..|...::|......|   |::|..|: ||:.||.:|::..|.:|.
Mouse   816 FGMLVFFIVWISFVPAYLSTKGKFKVAVEIFAI---LASSYGLLGCLFLPKCFIILLRPKRNT-- 875

  Fly   885 LTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDE 944
               :.||..|        .||        ...:..||..:|.:..:|:|:.|.    |||
Mouse   876 ---DETVGGR--------VPT--------VDRSIQLTSASVSSELNSTTVSTV----LDE 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	130/528 (25%)
		NCD3G	556..605	CDD:462210	16/53 (30%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	72/256 (28%)
		TM helix 1	625..650	CDD:320600	5/24 (21%)
		TM helix 2	662..683	CDD:320600	4/20 (20%)
		TM helix 3	692..716	CDD:320600	6/23 (26%)
		TM helix 4	738..758	CDD:320600	2/19 (11%)
		TM helix 5	781..807	CDD:320600	5/26 (19%)
		TM helix 6	815..838	CDD:320600	10/22 (45%)
		TM helix 7	845..870	CDD:320600	7/25 (28%)
Vmn2r1	NP_064302.2	PBP1_CaSR	51..538	CDD:380587	133/535 (25%)
		NCD3G	546..599	CDD:462210	16/53 (30%)
		7tmC_V2R-like	619..871	CDD:320407	72/258 (28%)
		TM helix 1	619..644	CDD:320407	5/24 (21%)
		TM helix 2	656..677	CDD:320407	4/20 (20%)
		TM helix 3	686..710	CDD:320407	7/25 (28%)
		TM helix 4	733..749	CDD:320407	2/15 (13%)
		TM helix 5	776..802	CDD:320407	5/25 (20%)
		TM helix 6	810..833	CDD:320407	10/22 (45%)
		TM helix 7	838..863	CDD:320407	7/27 (26%)