DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and grm3

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001121815.1	Gene:	grm3 / 565256	ZFINID:	ZDB-GENE-061009-13	Length:	884	Species:	Danio rerio

Alignment Length:	903	Identity:	438/903 - (48%)
Similarity:	586/903 - (64%)	Gaps:	66/903 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILD 102
            :.:.||::||||||:||||.|. .||....:||:|||||||:|||::|.|..:|||:.:||||||
Zfish    27 IKIDGDLVLGGLFPIHEKGMGMDECGRINEDRGIQRLEAMLFAIDQINQDVALLPGVVLGVHILD 91

  Fly   103 TCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANL 167
            |||||||||.|:|:||||||..:|.:.:.|.|||  ...:..|...:.||||||:||||:|||||
Zfish    92 TCSRDTYALEQALEFVRASLTKVDDTEFICPDGS--YALQEDSPLAIAGVIGGSFSSVSIQVANL 154

  Fly   168 LRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEY 232
            ||||.|||:|.|||:..||||:|:|.||||||||.:|:.|:.:||:.|||:||||:.|||.|||.
Zfish   155 LRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRAFNWTYVSTVASEGDYGET 219

  Fly   233 GIEALHKEATERNVCIAVAEKV-PSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAK 296
            ||||..::|..||:|||.:||| .|:|....:::::.:|.:||.||..|||.|::|||.::.||.
Zfish   220 GIEAFEQQARLRNICIATSEKVGRSSAKRSSYEAVVRQLLQKPTARVAVLFLRSDDARELIAAAA 284

  Fly   297 RANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFA 361
            |.|.|  |.|:||||||.|:.:::|.|..|:||||:||.:..|.||:||...|||:.|.|||||.
Zfish   285 RLNAS--FLWVASDGWGAQESIVKGNEFTADGAITLELAAHPIPDFNRYFQTLTPQINHRNPWFK 347

  Fly   362 EYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVY 426
            ::||..|.|.|..      ||.:...|       .|..||... :.:|..:|.|||..|||:|||
Zfish   348 DFWEQKFQCSLGG------TSATGAGT-------PKPPCDQEL-VIDKSNFEPESKIMFVVNAVY 398

  Fly   427 AFAYALHNLHNDRC-NTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLL 490
            |.|:|||.:....| ||                           ::.|..|.:.||::.|.::||
Zfish   399 AMAHALHRMQRTLCANT---------------------------TRLCDAMRSLDGRKLYRDFLL 436

  Fly   491 NVSF---IDLAG--SEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWN 550
            :|:|   ...||  |:||||..|||:.||:|.|||....|..:.|..:|:|...|.||...:.|.
Zfish   437 HVNFRAPFSPAGLESQVKFDAYGDGVGRYNIFNYQSVPGSDKFAYVQVGEWAESLSLNEGLIGWP 501

  Fly   551 KETEQPTSACSLPCEVGMIKKQQ-GDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYA 614
            :..:.|||.||.||....:||.| |:.|||||..||.:||:.|||||..|.||.||..|...||.
Zfish   502 RGADVPTSQCSDPCAPNEMKKMQAGEYCCWICTPCEPYEYLPDEFTCMPCAPGQWPRPDLTGCYD 566

  Fly   615 LDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNT 679
            |...|:.|...:|:.|::||..|...|.:|.::|.:::|||||:||||||.|.||.|:.:.|..|
Zfish   567 LPEDYIMWEDAWAIGPISIACVGFICTLMVFIVFIRHNDTPLVKASGRELCYILLLGVFMSYVMT 631

  Fly   680 FALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASK-SAQRLKYISPQSQVVITT 743
            |..||||:...|.|:|.|:|..|::.|||||||||||:|||....: .|||.::|||.|||.|..
Zfish   632 FIFIAKPSPIVCTLRRLGLGTSFAVCYSALLTKTNRIARIFSGVKEGGAQRPRFISPSSQVFICL 696

  Fly   744 SLIAIQVLITMIWMVVEPPGT-RFYYPDRRE-VILKCKIQDMSFLFSQLYNMILITICTIYAIKT 806
            |||::|:|:..:|::||.||| ||..|::|: |||||.::|.|.|.|..|:::|:.:||:||.||
Zfish   697 SLISVQLLLVSVWLLVEVPGTRRFTTPEKRQTVILKCNVRDSSMLMSLSYDVVLVVLCTVYAFKT 761

  Fly   807 RKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKV 871
            ||.||||||:|||||||||||||||||:||::.|.:.|.|||||:|||:|||..|.|.|:::|||
Zfish   762 RKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCMFAPKV 826

  Fly   872 YILVFHPDKNV--RKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPG-------TSAL 920
            :|::|.|.|||  .:|.||.......|.:.|..|..|:.|..|...|       ||:|
Zfish   827 HIIMFQPQKNVTSHRLNMNRFSVSGPATSYASHASVSAHYVPTVCNGREIVDSTTSSL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	242/506 (48%)
		ANF_receptor	72..518	CDD:279440	217/452 (48%)
		NCD3G	557..604	CDD:284890	27/47 (57%)
		7tm_3	638..873	CDD:278433	133/237 (56%)
grm3	NP_001121815.1	PBP1_mGluR_groupII	31..493	CDD:107370	242/506 (48%)
		ANF_receptor	61..471	CDD:279440	218/454 (48%)
		NCD3G	508..556	CDD:284890	27/47 (57%)
		7tm_3	590..828	CDD:278433	133/237 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580273
Domainoid	1	1.000	396	1.000	Domainoid score	I725
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H651
Inparanoid	1	1.050	826	1.000	Inparanoid score	I449
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0003689
OrthoInspector	1	1.000	-	-		otm24465
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24060
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.900