DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm2b

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001274476.1	Gene:	grm2b / 564461	ZFINID:	ZDB-GENE-060201-5	Length:	874	Species:	Danio rerio

Alignment Length:	910	Identity:	436/910 - (47%)
Similarity:	571/910 - (62%)	Gaps:	85/910 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILD 102
            :.:.||:::||||||||||:|. .||.....||:|||||||.|:|.:|.|..||||:.:|.||||
Zfish    33 IIIDGDLVIGGLFPVHEKGKGTEDCGKINEERGIQRLEAMLLALDEINQDNRILPGLKLGAHILD 97

  Fly   103 TCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGP------VFGVIGGSYSSVS 161
            |||:|||||.|||.||||||..:...|:.|.|||:|.        |      :.||||||||.||
Zfish    98 TCSKDTYALEQSLAFVRASLTKVHQPGFICPDGSNPV--------PDELPLAISGVIGGSYSDVS 154

  Fly   162 LQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSE 226
            :|||||||||.|||:|.|||:..||||:|:|.||||||||.:|:.|:.:||:.|||:||||:.||
Zfish   155 IQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAIAEILRYFNWTYVSTVASE 219

  Fly   227 GSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRI 291
            |.|||.||:|..:||..|.:|||.:.||..:.:...::::|..||:|.||:.|:||||:||||.:
Zfish   220 GDYGETGIDAFQQEARVRQICIATSVKVSRSVNQGNYETVIRSLQQKANAKVVILFTRSEDAREL 284

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            |.||.|.|::  |.|:||||||.|:.::...|..|.||.|:||.|..|.:|:.|..:||||.|.|
Zfish   285 LAAAARMNVT--FIWVASDGWGAQESVVHDSEKAANGAFTIELASYSIREFEDYFTKLTPELNTR 347

  Fly   357 NPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFV 421
            ||||.||||..|.|               |..|:  |..:|:..:|.::        .|||..||
Zfish   348 NPWFREYWEHNFGC---------------NLQDH--GCASKSLRNDLFK--------PESKIMFV 387

  Fly   422 VDAVYAFAYALHNLHNDRC-NTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFY 485
            |:||||.||||||:....| ||                           ::.|..|...:||.||
Zfish   388 VNAVYAMAYALHNMRQAVCPNT---------------------------TKVCDAMKPGNGKRFY 425

  Fly   486 NNYLLNVSF---IDLAGSE--VKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSE 545
            ..::|...|   ...|.:|  |:|...||.|.||:|.:|::::|.  |.|:.:|.|..||.||:.
Zfish   426 REFILKTKFDAPFRPADTENVVRFTSLGDSLGRYNIFHYRKEDNK--YVYRKVGYWAQGLVLNTS 488

  Fly   546 TVVWNKETEQPTSACSLPCEVGMIKKQQ-GDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADK 609
            .|.|.... .|||.||.||:....|..| ||.|||||..|:..:::.:||||.|||.|.||.|:.
Zfish   489 LVPWAGGV-APTSQCSDPCQPNEAKSMQPGDVCCWICIPCQPHQFLLNEFTCVDCGFGQWPLANL 552

  Fly   610 LSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILV 674
            ..||.|..:|:.|:..:|:.|:.||..|:..|..|..||.:::|||:|:||||||||.||||:|:
Zfish   553 TGCYELPEEYIHWSDAWAVGPVTIACLGMLCTLAVAGLFLRSNDTPVVKASGRELSYILLFGVLL 617

  Fly   675 CYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQV 739
            ||..||..||||:...|.|:|.|:|..|::.|||||||||||:|||..|..||||.::|||.|||
Zfish   618 CYAMTFIYIAKPSAFVCALRRLGLGTSFAVCYSALLTKTNRIARIFGGARDSAQRPRFISPASQV 682

  Fly   740 VITTSLIAIQVLITMIWMVVEPPGTRFYY-PDRREVI-LKCKIQDMSFLFSQLYNMILITICTIY 802
            .|..:||:.|:|:.::|::||.||.|... ||||:|: |||...|.|.|.|..||.|||.:||.|
Zfish   683 AICAALISAQLLVALVWLLVEAPGVRKEVGPDRRDVVTLKCNSLDSSMLVSLSYNCILIILCTFY 747

  Fly   803 AIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLY 867
            |.||||.||||||:|||||||||||||||||.||::.|.:.|.|||||:|||:|||.||.|.||:
Zfish   748 AFKTRKCPENFNEAKFIGFTMYTTCIIWLAFQPIFYVTASDYRVQTTTMCISVSLSGSVVLGCLF 812

  Fly   868 SPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSS 932
            :||::|::|.|.|||..|.....  |.|:|..|..:..|...:.|..|  :...|..|..:.:||
Zfish   813 APKIHIILFQPQKNVTSLRAKDN--RFSSAVTAPSSTYSQASASTIVP--TVCNGREVVDSTTSS 873

Fly 933 932
Zfish 874 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	235/511 (46%)
		ANF_receptor	72..518	CDD:279440	210/457 (46%)
		NCD3G	557..604	CDD:284890	24/47 (51%)
		7tm_3	638..873	CDD:278433	141/236 (60%)
grm2b	NP_001274476.1	PBP1_mGluR_groupII	37..487	CDD:107370	236/513 (46%)
		ANF_receptor	67..462	CDD:279440	209/456 (46%)
		NCD3G	499..547	CDD:284890	24/47 (51%)
		7tm_3	581..818	CDD:278433	141/236 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580271
Domainoid	1	1.000	396	1.000	Domainoid score	I725
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	826	1.000	Inparanoid score	I449
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0003689
OrthoInspector	1	1.000	-	-		otm24465
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.770