DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and olfcs1

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001038510.1	Gene:	olfcs1 / 564219	ZFINID:	ZDB-GENE-050419-111	Length:	844	Species:	Danio rerio

Alignment Length:	905	Identity:	259/905 - (28%)
Similarity:	415/905 - (45%)	Gaps:	114/905 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SPSNTHTQDSVSVSL--PGDIILGGLFPVH-----------EKGEGAPCGPKVYNRGVQRLEAML 78
            :|:.:..:..||.||  .||:|:|||||||           ::..|:.| ..:..|..:.|.||:
Zfish     8 NPTCSLKKSFVSESLYKDGDVIIGGLFPVHVQSPVPDPAFTQQQHGSNC-QGIDLRSYRWLRAMI 71

  Fly    79 YAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKN 143
            :.:|.:|.||.:||.:|:|..:.|||..::..|:.:|..|...    :|:.:......:|.:
Zfish    72 FTVDEINRDPVLLPNVTLGYLVADTCLAESTTLSAALALVTGQ----ETTVFSTECNGAPMV--- 129

  Fly   144 ASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVAL 208
                ||  :||.:.||.|:.||:.|.:|.||.||..::...||||.||..|.||||.|.||:.|:
Zfish   130 ----PV--IIGDARSSASVVVADTLGVFDIPMVSYFASCACLSDKHRFHTFLRTVPSDAFQAKAM 188

  Fly   209 VDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK 273
            ..:|...:|::|..:..:..||:.|...|.||.....||:...|.:|.:........|:.::|..
Zfish   189 ARLLHLLDWNWVGVVAGDDEYGKSGSHLLLKELEGSGVCVDYVEVIPKSHSQSRIKQIMERIQSS 253

  Fly   274 PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGK--QQKLLEGLEDIAEGAITVELQS 336
             .|..||.|....|...|.:.....|::.. .|||::.|..  |....|.:..:| |.|...|:.
Zfish   254 -TASVVVTFAIGPDLEVIFKEMVVQNVTNR-QWIATEAWSTTVQYSDPESIPLLA-GTIGFALRR 315

  Fly   337 EIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECD 401
            ..|.....::.||.|......|:..:.||:.|.|.|              :.|.:...| :.:|.
Zfish   316 AEIKGLGAFLTQLNPVKQSNEPFVKDVWEEIFRCSL--------------AHDRQPSFK-RPKCT 365

  Fly   402 DSYRLSEKVG--YEQESK---TQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWY 461
            .|..: ||.|  |...|:   |..|..||||.||||||:  ..|             |.....:
Zfish   366 GSESV-EKHGRIYTDVSQLRVTYNVYKAVYAIAYALHNM--IAC-------------LPGRGPF- 413

  Fly   462 RKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSS 526
                   ::..|||......::.. :||..|:|....|..|.|:..|:..|.|||:|:  ..|.|
Zfish   414 -------ENGQCPDATQVKPRQLL-HYLNAVNFTTPVGELVYFENNGEPSASYDIMNW--YVNKS 468

  Fly   527 G-YQYKVIGKW------FNGLQLNSETVVWNK--ETEQPTSACSLPCEVGMIK--KQQGDTCCWI 580
            | ..:..:|::      ...|.:|.|.|:|..  ..:.|.|.||:.|..|..|  :::...||:.
Zfish   469 GEVNFVQVGQYDAAKGPGQELNINIEKVIWGGGWGNQVPVSVCSVSCLPGTRKVVQKRKPICCFD 533

  Fly   581 CDSCESFEY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSI 643
            |..|.:.|.  :.|...|..|....|...:|..|....::::.......::...:::.|..||:.
Zfish   534 CIPCAAGEISNMSDSTECMRCPEKFWSNTEKTKCIPKVVEFLSLQDTMGIVLTVLSVTGATLTTT 598

  Fly   644 VIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSA 708
            |:..|..:.|||||||...|||:.||..:.:|:......|.:|...:|:|:....||.|......
Zfish   599 VLATFFHHRDTPLVRAYNSELSFLLLMSLTLCFLCALVFIGRPAAWNCMLRHTLFGVSFVTCIGC 663

  Fly   709 LLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPP---------GT 764
            :|:||..:...|.:....:..::|..|..|.........:||:|.::|::::||         |.
Zfish   664 ILSKTVVVLVAFRATRPGSHLMQYFGPIQQRAAIFICTLVQVVICLLWLLLDPPQPTESAGELGA 728

  Fly   765 RFYYPDRREVILKCKIQD-MSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCI 828
            |        :||:|.:.. :.|:|...|..:|..:|.:.|...||:|:||||:|||.|:|:..|.
Zfish   729 R--------LILQCTVGSVVGFVFVLGYIGMLAVVCFLLAFFARKLPDNFNEAKFITFSMFIFCA 785

  Fly   829 IWLAFVPIYFGTGNSYEVQTTTLCISISLSASVA-LVCLYSPKVYILVFHPDKNVRKLTM 887
            :|.||||.|..:...|.|......|   |::|.. |:|:::||.||::..|:||.:|..|
Zfish   786 VWAAFVPAYISSPGKYTVAVEIFAI---LASSYGLLICIFTPKCYIILLKPEKNTKKTMM 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	148/523 (28%)
		ANF_receptor	72..518	CDD:279440	129/452 (29%)
		NCD3G	557..604	CDD:284890	14/50 (28%)
		7tm_3	638..873	CDD:278433	76/245 (31%)
olfcs1	NP_001038510.1	Periplasmic_Binding_Protein_Type_1	24..498	CDD:299141	151/532 (28%)
		ANF_receptor	65..463	CDD:279440	129/453 (28%)
		NCD3G	508..559	CDD:284890	14/50 (28%)
		7tm_3	603..828	CDD:278433	73/235 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910