DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and gprc5c

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001103183.1	Gene:	gprc5c / 563405	ZFINID:	ZDB-GENE-070928-27	Length:	429	Species:	Danio rerio

Alignment Length:	426	Identity:	94/426 - (22%)
Similarity:	159/426 - (37%)	Gaps:	94/426 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 KDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFG-IALTSIVIVLFAKNHDTPLVRAS 660
            |.||..:    |.|.....|:     ::::.::..|.|..| :|...::|||.|   ..|.:.:.
Zfish    32 KGCGTNM----DSLYFNLCDL-----SAVWGVVVEAFAAAGLVASLILLIVLLA---SLPFINSK 84

  Fly   661 GRELSYTL-------LFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISR 718
            ....|:.|       .||:   :..|||.|......:|..:||..||.|:..:|.||.:..|::.
Zfish    85 NWRSSFGLHTVFLIFTFGL---FALTFAFIVGKNFATCASRRFLFGVLFAGCFSCLLMQAVRLNI 146

  Fly   719 IFHSASKSAQRLKYISPQSQV--VITTSLIAIQVLITMIWMVVEPPGTRFYYPDR------REVI 775
            :....|         .|:..|  :....|..::|:|...|:::    |...||..      ..:.
Zfish   147 LARRNS---------GPRGWVWCLGALGLWLVEVVINTEWLII----TIVRYPVNITGTIAPVLA 198

  Fly   776 LKCKIQDMSFLFSQLY--NMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYF 838
            :.|.|.:..|:.:.:|  |::|..:.....|...|..:...:...|..|...:..||:|::.:|.
Zfish   199 IPCNIANQDFVMALIYVLNLLLAVVVASVPIMAGKHKQWRKDGALILVTGLLSVGIWVAWIVMYV 263

  Fly   839 GTGNSYEVQTT----TLCISISLSASVALVCLYSPKVYILV-----------FHPDK---NVRKL 885
             :||:.....|    ||.|::..:|.|.|:....|.|..|.           .:|.:   |:.|.
Zfish   264 -SGNAKNGGPTWDDPTLAIALVSNAWVFLLLHTVPAVCSLSEEGEDEPVAEDMYPSRGYENMLKE 327

  Fly   886 TMNSTVYRRSAA-----AVAQGAPTS--SGY-----SRTHAPGTSALTGGAVGT----------N 928
            .....::..:.|     ..|...|.|  |||     |..:.|...|:.....|.          .
Zfish   328 QSAQNIFMENKAFSMDEPNAGNKPVSPYSGYNGQLRSCVYQPTELAIITKGTGNQLESYDNVIPR 392

  Fly   929 ASSSTLPTQNSPHLDEASAQTNVAHK----TNGEFL 960
            ||:.|.|...|   ...|..|.:...    |||.|:
Zfish   393 ASTGTPPRAQS---GSTSPTTQLEDMRKIYTNGNFI 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141
		ANF_receptor	72..518	CDD:279440
		NCD3G	557..604	CDD:284890	3/6 (50%)
		7tm_3	638..873	CDD:278433	59/255 (23%)
gprc5c	NP_001103183.1	7tmC_RAIG3_GPRC5C	51..304	CDD:320404	63/272 (23%)
		TM helix 1	51..76	CDD:320404	7/24 (29%)
		TM helix 2	90..111	CDD:320404	6/23 (26%)
		TM helix 3	120..144	CDD:320404	8/23 (35%)
		TM helix 4	161..177	CDD:320404	3/15 (20%)
		TM helix 5	204..230	CDD:320404	4/25 (16%)
		TM helix 6	240..263	CDD:320404	5/22 (23%)
		TM helix 7	273..298	CDD:320404	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910