Protein Alignment mGluR and olfcr1

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: NP_001417787.1
• Gene: olfcr1 / 562852
• ZFINID: ZDB-GENE-060503-302
• Length: 864
• Species: Danio rerio
• Alignment Length: 922
• Identity: 244/922 - (26%)
• Similarity: 416/922 - (45%)
• Gaps: 113/922 - (12%)

  Fly     9 TILVVVMVL-----SWSRVVDLKSPSNTHT---QDSVSVSLPGDIILGGLFPVH----------- 54
            |:.|.|::|     |.:.|..|::.....|   .|.:.....||:|:|||..:|
Zfish    10 TLSVPVLLLWPVCGSGTEVTPLETCVYLITPQYSDELGTYQDGDVIIGGLINLHNLAATPDLSFT 74

  Fly    55 EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVR 119
            .|...|.| .:...|..:..:|:::.::.:|..|::|||:.:|.||:|:|||..::|..::..:.
Zfish    75 RKPGLAQC-LEFQERTYRWFQAIVFTVEEINQHPSLLPGVKLGYHIMDSCSRYPHSLTAAMSMIS 138

  Fly   120 ASLNNLDTSGYECADGSSPQLRKNASSGPVFG---VIGGSYSSVSLQVANLLRLFHIPQVSPAST 181
            ..                     |.:.||...   :||.|.|:.|:.::..|....||.:|..:.
Zfish   139 GG---------------------NKTCGPTKPAKLLIGDSSSTQSILLSTTLVPLKIPMISYLAG 182

  Fly   182 AKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNV 246
            ...|||:.::..|.||:|.|.:|:..:|.|.|.|.|:::..:.::...|...::||.:|.....:
Zfish   183 CPCLSDRQKYPNFFRTIPSDFYQARTMVQIAKRFGWTWIGAVIADSDNGHGTLQALEEEIKGTGI 247

  Fly   247 CIA-----VAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHW 306
            |:|     ..|::..   |..|   .::..:..:||.:::.....|....|....|.|::... :
Zfish   248 CLAFYHTLYRERLQK---DVAF---AARTVQASSARVILVLAWYTDVEAFLLELMRRNVTDRL-F 305

  Fly   307 IASDGWGKQQKLLEG--LEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFN 369
            :||:.|.....::..  |..|::|.:.|.|:|..|..|..::.||.|.....:.:....||:||.
Zfish   306 LASEIWSTSYNIMANPQLYTISKGTLGVALRSAPIPGFSAHLQQLHPSRYPEDKFLRTLWENTFG 370

  Fly   370 CVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHN 434
            |..| :|......||......:..::...|..|:..|:  |.|.       :..||||.|:|||:
Zfish   371 CSPT-ISSSKIIQNSLPPCSGRESLEGHIEFIDTSHLT--VSYN-------IYLAVYAAAHALHS 425

  Fly   435 LHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTK-SQACPDMANYDGKEFYNNYLLNVSFIDLA 498
            |.  .||:|:                    .||:| ...|....|....:.. .::.:|.:....
Zfish   426 LL--ECNSQN--------------------HTDSKIKPKCSSPDNITPAQLL-QHVKDVQYTTQL 467

  Fly   499 GSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKW-FNGLQLNSETVVWNKET-EQPTSACS 561
            |.|..| .:|.....||::|:|...:.| .||..||.. .|.|.:|...:.|..:: :.|.|.|:
Zfish   468 GEEFYF-LEGGIPPVYDLVNWQIAPDGS-LQYAFIGHVDGNQLSINDSAITWPGDSGKVPISVCT 530

  Fly   562 LPCEVGMIK--KQQGDTCCWICDSCESFEYVYD--EFTCKDCGPGLWPYADKLSCYALDIQYMKW 622
            ..|..|..|  |:....||:.|..|...|....  ...|..|....|..:.|..|.|.:.:::..
Zfish   531 SECPPGTRKAIKKGLPVCCFDCLPCTEGEISNSTGSIKCYRCPKEFWSNSYKNECVARETEFLSV 595

  Fly   623 NSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPT 687
            .....:..|::|:.|..:|:.|.|:|..:.:||:|:|:..|||:.||..:.:|:......:.:|:
Zfish   596 KETMGITLMSVAVSGAVMTTTVAVIFLYHRNTPIVKANNSELSFLLLLSLKLCFLCALVFVGQPS 660

  Fly   688 IGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSA-SKSAQRLKYISPQSQVVITTSLIAIQVL 751
            :.||.:|:...|:.|.:..|.:|.||..:...|||. .:|:..:|:.....|..|......:||:
Zfish   661 LWSCRIQQAAFGISFVLCISCILVKTFVVLIAFHSTRPESSALIKWFGLGKQRGIVLVFTCVQVV 725

  Fly   752 ITMIWMVVEPPGTRFYYPD----RREVILKCKIQD-MSFLFSQLYNMILITICTIYAIKTRKIPE 811
            |..||:.|.||   ..|.:    |.:|||:|.|.. :.|.....|...|.|:|.:.|...||:|:
Zfish   726 ICAIWLCVSPP---LPYQNFGMHRSKVILECTIGSVVGFTCVLGYIGFLATVCFLLAFFARKLPD 787

  Fly   812 NFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILV 875
            ||||:|:|.|:|...|.:|:||||.|..:...|.|......|   |::|..|: |::.||.||::
Zfish   788 NFNEAKYITFSMLIFCAVWVAFVPAYVSSPGKYSVVVEVFAI---LASSFGLLFCIFVPKCYIIL 849

  Fly   876 FHPDKNVRKLTM 887
            ..|:.|.:|..|
Zfish   850 LKPENNTKKFLM 861

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	127/525 (24%)
		NCD3G	556..605	CDD:462210	14/52 (27%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	84/257 (33%)
		TM helix 1	625..650	CDD:320600	7/24 (29%)
		TM helix 2	662..683	CDD:320600	6/20 (30%)
		TM helix 3	692..716	CDD:320600	7/23 (30%)
		TM helix 4	738..758	CDD:320600	7/19 (37%)
		TM helix 5	781..807	CDD:320600	6/26 (23%)
		TM helix 6	815..838	CDD:320600	11/22 (50%)
		TM helix 7	845..870	CDD:320600	6/25 (24%)
olfcr1	NP_001417787.1	Periplasmic_Binding_Protein_type1	55..517	CDD:471960	126/525 (24%)
		NCD3G	525..578	CDD:462210	14/52 (27%)
		7tmC_V2R_pheromone	598..850	CDD:320410	84/257 (33%)
		TM helix 1	598..623	CDD:320410	7/24 (29%)
		TM helix 2	635..656	CDD:320410	6/20 (30%)
		TM helix 3	665..689	CDD:320410	7/23 (30%)
		TM helix 4	714..730	CDD:320410	4/15 (27%)
		TM helix 5	757..783	CDD:320410	6/25 (24%)
		TM helix 6	791..814	CDD:320410	11/22 (50%)
		TM helix 7	819..844	CDD:320410	7/27 (26%)