DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and casr

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_017211901.1	Gene:	casr / 560607	ZFINID:	ZDB-GENE-050119-8	Length:	956	Species:	Danio rerio

Alignment Length:	990	Identity:	286/990 - (28%)
Similarity:	468/990 - (47%)	Gaps:	129/990 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVH----EKGEGAPCGPKV-----YN- 68
            :::|..|.|:....| |...|.:      |||:||||||:|    .|.:.....|:.     ||
Zfish    12 LVLLGSSCVISTYGP-NQRAQKT------GDILLGGLFPMHFGVASKDQDLAARPESTECVRYNF 69

  Fly    69 RGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFV-RASLNNLDTSGYEC 132
            ||.:.|::|::||:.:||...:||.||:|..|.|||:..:.||..||.|| :..:::|:...:..
Zfish    70 RGFRWLQSMIFAIEEINNSSTLLPNITLGYRIFDTCNTVSKALEASLSFVAQNKIDSLNLDEFCN 134

  Fly   133 ADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFART 197
            ..|:.|.         ...|:|.|.|:||..||:||.||:|||:|.||:::.||:|.::..|.||
Zfish   135 CTGNIPS---------TIAVVGASGSAVSTAVADLLGLFYIPQISYASSSRLLSNKNQYKSFMRT 190

  Fly   198 VPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKV 262
            :|.|.:|::|:..|:::|.|::|..|.|:..||..|||....|...|::||.:...:....|:..
Zfish   191 IPTDEYQAIAMAAIIEHFQWNWVIAIASDDEYGRPGIEKFENEMFHRDICIDLNVLISQYVDEAE 255

  Fly   263 FDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLL--EGLEDI 325
            ...:..::|.. :|:.:|:|....|...:::...|.|::... |:||:.|.....:.  |.| |:
Zfish   256 IRRLADRIQNS-SAKVIVVFASGPDIEPLVKEMVRRNITDRV-WLASEAWASSSLVAKPEYL-DV 317

  Fly   326 AEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANS--- 387
            ..|.|...|::..|..|..::.|:.|:.:..|.:..|:||:||||.|.......|:.|.:.|
Zfish   318 MGGTIGFALRAGHIPGFKDFLQQVHPKKSSHNEFVREFWEETFNCYLEDSPRNADSENGSTSFRP 382

  Fly   388 --TDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTET 450
              |..:.....:|...|...|  ::.|.       |..||||.|.||.::          .|...
Zfish   383 LCTGEEDIASVETPYLDYTHL--RISYN-------VYVAVYAIAQALQDI----------LTCTP 428

  Fly   451 RKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYD 515
            .|.|.|..             :|.|:...:..:.... |.:::|||..|..|:||...:..|.|.
Zfish   429 GKGLFSNG-------------SCADIRKVEAWQVLKQ-LRHLNFIDSMGERVRFDNGSELSANYT 479

  Fly   516 ILNYQRQENSSGYQYKVIG------KWFNGLQLNSETVVWNKETEQ-----------PTSACSLP 563
            |:|:.|........:|.:|      |....|.::...::||....:           |.|.||:.
Zfish   480 IINWHRSPEDGSVVFKEVGYYSIHNKNVAKLSIDKSKILWNGRLTEVMCCFSFLYQVPFSNCSVE 544

  Fly   564 CEVGMIKK-QQGD-TCCWICDSCESFEYV--YDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNS 624
            ||.|..|. ..|: |||:.|..|...||.  .|...|..|....|...:..||:...|:::.|..
Zfish   545 CEPGTRKGIIDGEPTCCFECTECSDGEYSDHKDASFCVKCPNNSWSNGNHTSCFLKQIEFLSWTE 609

  Fly   625 LFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIG 689
            .|.:.....|:.|:.||:.|:.:|.:..|||:|:||.||||:.|||.::.|:.::...|.:|...
Zfish   610 PFGIALALFAVLGVLLTAFVLGVFVQFRDTPIVKASNRELSFLLLFSLICCFSSSLIFIGEPQDW 674

  Fly   690 SCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITM 754
            :|.:::...|:.|.:..|.:|.||||:..:|.:...::...|:.....|.::......:||:|.:
Zfish   675 TCRVRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLFTFVQVMICV 739

  Fly   755 IWMVVEPPGTRFYYPDRREVILKC---KIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNES 816
            :|:...|||:...|.....:.:.|   .:..:.||..  |..:|..||..:|.|:||:||||.|:
Zfish   740 VWLYNAPPGSYKNYDIDEIIFITCNEGSMMALGFLIG--YTCLLAAICFFFAFKSRKLPENFTEA 802

  Fly   817 KFIGFTMYTTCIIWLAFVPIYFGTGNSY----EVQTTTLCISISLSASVALVCLYSPKVYILVFH 877
            |||.|:|....|:|::|:|.||.|...:    ||      |:|..|:...|.|::..||||::..
Zfish   803 KFITFSMLIFFIVWISFIPAYFSTYGKFVSAVEV------IAILASSFSLLACIFFNKVYIILLK 861

  Fly   878 PDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHL 942
            |.:|..:....||......||.......|||:.:     .|:..||:..::.|||
Zfish   862 PSRNTIEEVRCSTAAHAFKAAAKATLRHSSGFRK-----RSSSVGGSSASSPSSS---------- 911

  Fly   943 DEASAQTNVAHKTNG 957
                    ::.||||
Zfish   912 --------ISMKTNG 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	153/522 (29%)
		ANF_receptor	72..518	CDD:279440	131/453 (29%)
		NCD3G	557..604	CDD:284890	18/50 (36%)
		7tm_3	638..873	CDD:278433	77/241 (32%)
casr	XP_017211901.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810