Protein Alignment mGluR and olfcq12

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_683954.6
• Gene: olfcq12 / 556129
• ZFINID: ZDB-GENE-060503-735
• Length: 894
• Species: Danio rerio
• Alignment Length: 896
• Identity: 246/896 - (27%)
• Similarity: 410/896 - (45%)
• Gaps: 133/896 - (14%)

  Fly    43 GDIILGGLFPVH---------EKGEGAPCGPKVYN-RGVQRLEAMLYAIDRVNNDPNILPGITIG 97
            ||:||||||.||         .:.|..|...:.:: ...|:.:.|::|||.:|.:||:||.||:|
Zfish    74 GDLILGGLFEVHFLTVFPEQSFRTEPEPPYCEQFDMASFQQAQTMVFAIDEINRNPNLLPNITLG 138

  Fly    98 VHILDTCSRDTYALNQSLQFV---RASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSS 159
            .::.|.|.:.:.|...::..|   ..|.::|:.:|                ..||..::|...|:
Zfish   139 YYLYDNCVKLSVAFRAAMALVSGTEESFSSLNCTG----------------PPPVIAIVGDPGST 187

  Fly   160 VSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIH 224
            .|:.::::|.||.:|.||..:|...|||:..:..|.||:|.|.||..|:|.|||.|.|::|..::
Zfish   188 HSIAISSILGLFRVPMVSYFATCSCLSDRKTYPSFFRTIPSDAFQVRAMVQILKRFGWTWVGLLY 252

  Fly   225 SEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDAR 289
            |:..||.|..::..||......|:..:|.:|...:.:...||:..:|.. .||.||:|:......
Zfish   253 SDDDYGIYAAQSFQKEMQLFGACVGFSEMLPRDNNHEDIQSIVEVIQTS-TARVVVVFSTEAYLL 316

  Fly   290 RILQAAKRANLSQPFHWIASDGWGKQ-----QKLLEGLEDIAEGAITVELQSEIIADFDRYMMQL 349
            .::......|::.. .||||:.|...     |.||..|    .|.:.:.::...|.....::..|
Zfish   317 PLMDEVALKNVTGR-QWIASEAWATSPVFHTQHLLPFL----GGTLGIAIRRGEIQGLKEFLYYL 376

  Fly   350 TPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRL-SEKVGYE 413
            .|::|.||.....:||:.|.|..                  :||.:.:..|.....| |....|.
Zfish   377 HPDSNTRNNIVRIFWENIFGCSF------------------EIGGRERKVCTGQEDLKSTNTAYT 423

  Fly   414 QES---KTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTK----SQ 471
            ..|   .:.....||||.|:|||:|                  :|.|         |.:    ..
Zfish   424 DVSGLRASYNAYKAVYALAHALHDL------------------MQCE---------DGRGPFSGN 461

  Fly   472 ACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQEN-----------S 525
            .|.|..|....:.. :||..|:|....|..|.||..||.||.||::|:|...:           :
Zfish   462 KCADQINLQPWQVV-HYLQKVNFTTGFGDHVSFDENGDALAIYDVMNWQPSSDGAISVSTVGVVN 525

  Fly   526 SGYQYKVIGKWFNGLQLNSETVVWN-KETEQPTSACSLPCEVG--MIKKQQGDTCCWICDSCESF 587
            .|...|::      |.|...::.|| |..:.|.|.||..|..|  .::::....||:.|..|...
Zfish   526 EGASMKMV------LTLKENSIFWNFKNRKPPQSVCSESCPPGTRQVRRKGLPVCCFDCLPCADG 584

  Fly   588 EY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAK 650
            |.  ..|...||.|...|||..:|..|...:..::.:.....:.....::.|....::|:|:|:.
Zfish   585 EISNTTDAIECKICPDELWPNPNKDQCVPKEEDFLSFEDPLGISLTTASLLGTCFCALVMVIFSH 649

  Fly   651 NHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNR 715
            :.:||:|||:..|||:.||..:.:|:......|.:|.:.:|.|:....|:.|.:..|::|.||..
Zfish   650 HRNTPVVRANNSELSFLLLLSLKLCFLCVLLFIGRPKLWTCQLRHAAFGISFVLCVSSILVKTMV 714

  Fly   716 ISRIFHSA---SKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVV---EPPGTRFYYPDRREV 774
            :..:|.|:   ||||.:...::.|...|:  :|..:|::|..:|:.:   :|.....|...:  |
Zfish   715 VIAVFKSSRPESKSAMKWFGVAQQRGTVM--ALTTLQIVICTVWLSMASPKPYKNSLYISSK--V 775

  Fly   775 ILKCKIQDMSFLFSQL--YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIY 837
            :.:|.|..: ..||.|  |..:|..:..::|...|.:|:||||:|||.|:|...|.:|:.|||.|
Zfish   776 VYECDIGSV-VGFSLLLGYIGLLAAVSFLFAFLARNLPDNFNEAKFITFSMLIFCAVWITFVPAY 839

  Fly   838 FGTGNSYEVQTTTLCISISLSASVA-LVCLYSPKVYILVFHPDKNVRKLTM 887
            ..:...|.|......|   |::|.. ||.:::||.|:::|||::|.:|..|
Zfish   840 VSSPGKYAVAVEIFAI---LASSFGLLVAIFAPKCYMILFHPERNTKKSIM 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	141/535 (26%)
		NCD3G	556..605	CDD:462210	16/52 (31%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	75/259 (29%)
		TM helix 1	625..650	CDD:320600	4/24 (17%)
		TM helix 2	662..683	CDD:320600	6/20 (30%)
		TM helix 3	692..716	CDD:320600	7/23 (30%)
		TM helix 4	738..758	CDD:320600	5/19 (26%)
		TM helix 5	781..807	CDD:320600	6/27 (22%)
		TM helix 6	815..838	CDD:320600	11/22 (50%)
		TM helix 7	845..870	CDD:320600	6/25 (24%)
olfcq12	XP_683954.6	None