DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm1a

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_002665785.3	Gene:	grm1a / 555576	ZFINID:	ZDB-GENE-030131-7893	Length:	1153	Species:	Danio rerio

Alignment Length:	943	Identity:	371/943 - (39%)
Similarity:	542/943 - (57%)	Gaps:	95/943 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LPGDIILGGLFPVH-----EKGEGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHI 100
            :.||:|:|.||.||     |:.....||......|:||:|||.:.:||:|.|.|:||.||:|..|
Zfish    53 MDGDVIIGALFSVHHQPSAERVADRKCGDVREQYGIQRVEAMFHTLDRINADQNLLPNITLGCEI 117

  Fly   101 LDTCSRDTYALNQSLQFVRASLNNL--DTSGYE-CADGSSPQLRKNASSGPVFGVIGGSYSSVSL 162
            .|:|...:.||.||::|:|.||.::  |..|.: |.|| :|..:...|..|:.||||...|||::
Zfish   118 RDSCWHSSVALEQSIEFIRDSLISIRDDKDGSKWCIDG-TPSNQPPPSKKPIAGVIGPGSSSVAI 181

  Fly   163 QVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEG 227
            ||.|||:||:|||::.::|:..|||||.|..|.|.||.||.|:.|::||:|::||:|||.:|:||
Zfish   182 QVQNLLQLFNIPQIAYSATSIDLSDKTLFKYFLRVVPSDTLQARAMLDIVKHYNWTYVSAVHTEG 246

  Fly   228 SYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKK-PNARGVVLFTRAEDARRI 291
            :|||.|:||..:.|.|..:|||.::|:.|.|.:|.||.::.||::: |.||.||.|......|.:
Zfish   247 NYGESGMEAFKELAAEEGLCIAHSDKIYSNAGEKHFDRLLKKLRERLPKARVVVCFCEGMTVRSL 311

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            |.|.:|..:|..|..|.||||..:.:::||.|..|:|.||::||:|.:..|:.|.::|..:||:|
Zfish   312 LMAMRRRGVSGEFQLIGSDGWADRDEVVEGYEQEADGGITMKLQTEEVQSFNDYFLKLRLDTNKR 376

  Fly   357 NPWFAEYWEDTFNCVLTSLSVKPDTSNSANS--TDNKIGVKAKTECDDSYRLSEKVGYEQESKTQ 419
            ||||||:|:..|.|.:..   .|..:::...  |.|:               |.|..|.|:||..
Zfish   377 NPWFAEFWQYRFQCRIPG---HPQENHNYQKICTGNE---------------SLKDNYVQDSKMG 423

  Fly   420 FVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEF 484
            ||::|:||.|:.||::|.:.|...|.                          .|..|...||.:.
Zfish   424 FVINAIYAMAHGLHDMHREMCPEHSG--------------------------LCEAMDPIDGSKL 462

  Fly   485 YNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVW 549
            . :|||..||..::|.|:.||..||...||||:|.|..|....:.|..:|.|..||...|:..:.
Zfish   463 L-DYLLKTSFSGVSGEEIYFDVNGDSPGRYDIMNLQYVEEIGRFDYINVGSWHEGLLSISDYKLM 526

  Fly   550 NKETEQPTSACSLPCEVGMIKK-QQGD-TCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSC 612
            ...||...|.||.||..|.||. ::|: :|||||.:|:..|||.|||||:.|..|.||..:...|
Zfish   527 TNRTEMVRSVCSEPCSKGQIKVIRKGEVSCCWICTTCKDNEYVQDEFTCRACDLGWWPDDELAEC 591

  Fly   613 YALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYC 677
            ..|.::|::|.|:.::|.:..:..||.:|..|..:|.:..|||:|::|.|||.|.:|.||.:.|.
Zfish   592 KPLPLKYLEWGSVESIIAVVFSCVGILVTLFVTFIFFQYSDTPVVKSSSRELCYIILAGIFLGYI 656

  Fly   678 NTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS--AQRLKYISPQSQVV 740
            ..|.|||:||:.||.|||..:|:..::.||||:||||||:||...:.|.  .::.:::|..:|||
Zfish   657 CPFTLIARPTVISCYLQRILVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVV 721

  Fly   741 ITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKIQDMSFLFSQLYNMILITICTIYAIK 805
            |...||::|:.:.:..||:|||.....||..|||.|.|...::..:....||.:||..||.||.|
Zfish   722 IAFMLISLQLAVVVTLMVLEPPEPVKSYPSIREVYLICNTSNVGVVAPLGYNGLLIMSCTYYAFK 786

  Fly   806 TRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPK 870
            ||.:|.||||:|:|.||||||||||||||||||  |::|::.||:  .|:|||.:|||.|:::||
Zfish   787 TRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYF--GSNYKIITTS--FSVSLSVTVALGCMFTPK 847

  Fly   871 VYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAV---------G 926
            :||::..|::|||.....|.|.|..   |..|.|         ||..|    .::         .
Zfish   848 MYIIIAKPERNVRSAFTTSDVVRMH---VGDGKP---------APCQS----NSILNMFRRKKNN 896

  Fly   927 TNASSSTLPTQNSPHLDEASAQ-----TNVAHK 954
            .||:.||.|...|....|:.|:     ::|.|:
Zfish   897 NNATGSTNPNGKSVSWSESGARPQGRGSSVFHR 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	197/509 (39%)
		ANF_receptor	72..518	CDD:279440	177/451 (39%)
		NCD3G	557..604	CDD:284890	25/48 (52%)
		7tm_3	638..873	CDD:278433	112/236 (47%)
grm1a	XP_002665785.3	PBP1_mGluR_groupI	48..523	CDD:107369	198/515 (38%)
		ANF_receptor	89..497	CDD:279440	178/453 (39%)
		NCD3G	534..583	CDD:284890	25/48 (52%)
		7tm_3	617..850	CDD:278433	112/236 (47%)
		GluR_Homer-bdg	1110..1153	CDD:287563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820