DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mGluR and GPRC5D

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_061124.1	Gene:	GPRC5D / 55507	HGNCID:	13310	Length:	345	Species:	Homo sapiens

Alignment Length:	380	Identity:	83/380 - (21%)
Similarity:	151/380 - (39%)	Gaps:	74/380 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   597 KDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLF----AKNHDTPLV 657
            |||......|.  |.|.|        ...:.:|..::||.||.:|.::::.|    .|..|....
Human     3 KDCIESTGDYF--LLCDA--------EGPWGIILESLAILGIVVTILLLLAFLFLMRKIQDCSQW 57

  Fly   658 RASGRELSYTL----LFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISR 718
            .....:|.:.|    |||:      .||.|.:....:..::.|..||.|::.:|.||...:.:.:
Human    58 NVLPTQLLFLLSVLGLFGL------AFAFIIELNQQTAPVRYFLFGVLFALCFSCLLAHASNLVK 116

  Fly   719 IFHS-ASKSAQRLKYIS---PQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCK 779
            :... .|.|...:..|:   ...|::|.|..:.:.:...|:::.:.|                |:
Human   117 LVRGCVSFSWTTILCIAIGCSLLQIIIATEYVTLIMTRGMMFVNMTP----------------CQ 165

  Fly   780 IQDMSFLFSQLYNMILITICTIYAIKTRKIP-ENFNE-SKFIGFTMYTTCIIWLAFVPIYFGTGN 842
            : ::.|:...:|.:.|:.:....:..|...| ||:.: .:.|..|:..:.|||:.::.:......
Human   166 L-NVDFVVLLVYVLFLMALTFFVSKATFCGPCENWKQHGRLIFITVLFSIIIWVVWISMLLRGNP 229

  Fly   843 SYEVQ----TTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNS---TVYRRSAAAVA 900
            .::.|    ...:||::..:|.|.|:....|::.|| :...:....|..|:   |.|:.|.....
Human   230 QFQRQPQWDDPVVCIALVTNAWVFLLLYIVPELCIL-YRSCRQECPLQGNACPVTAYQHSFQVEN 293

  Fly   901 Q---GAPTSSGYSRTHAPGTSALTGGAVGTNASSSTL-PTQN--------SPHLD 943
            |   .|..|.|     |....|||  :.||.....|: |||.        ||..|
Human   294 QELSRARDSDG-----AEEDVALT--SYGTPIQPQTVDPTQECFIPQAKLSPQQD 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141
		ANF_receptor	72..518	CDD:279440
		NCD3G	557..604	CDD:284890	3/6 (50%)
		7tm_3	638..873	CDD:278433	48/252 (19%)
GPRC5D	NP_061124.1	7tm_GPCRs	21..267	CDD:333717	54/269 (20%)
		TM helix 1	22..46	CDD:320095	7/23 (30%)
		TM helix 2	60..81	CDD:320095	7/26 (27%)
		TM helix 3	90..112	CDD:320095	7/21 (33%)
		TM helix 4	131..147	CDD:320095	4/15 (27%)
		TM helix 5	166..189	CDD:320095	3/23 (13%)
		TM helix 6	200..225	CDD:320095	5/24 (21%)
		TM helix 7	236..261	CDD:320095	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910