DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vmn2r22

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001098107.1	Gene:	Vmn2r22 / 546913	MGIID:	3647952	Length:	853	Species:	Mus musculus

Alignment Length:	923	Identity:	222/923 - (24%)
Similarity:	390/923 - (42%)	Gaps:	166/923 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 SPSNTHTQDSVSVSLPGDIILGGLFPV-----HEK-----GEGAPCGPKVY---NRGVQRLEAML 78
            |.|..:.||       ||.::||.|.:     |.|     |........||   .:..|.:.||:
Mouse    28 SASPGYYQD-------GDFVIGGFFSLKLSGRHSKNKFTSGNEYNIPEYVYIDFTKHYQHILAMV 85

  Fly    79 YAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKN 143
            :||:::|.|||||..:::|.|:.:....:..|:..|:..:               .|.||.: .|
Mouse    86 FAIEKINKDPNILFNMSLGFHVFNADFTEMKAMKSSMVLL---------------SGESPPI-PN 134

  Fly   144 ASSGP-----VFGVIGGSYSSVSLQVANLLRLFHIPQVSPA------STAKTLSDKTRFDLFART 197
            .|..|     :..||||..:.:|.|::.:|.|:::||:|.|      .|:..|....:|.:....
Mouse   135 YSCRPEKTDKLVAVIGGISTGISTQISRVLSLYNVPQISYAPFDQSLGTSVQLQSPYQFTVHTAA 199

  Fly   198 VPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKV 262
            :    :|.:  :.:|..|.|.:|..:..:...||..:..:.:|.....:|:|.|||||....:
Mouse   200 L----YQGI--IQLLLYFTWVWVGLVVPDDIRGELFLRDITEEMMNHGLCVAFAEKVPEILGE-- 256

  Fly   263 FDSIISK--LQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFH--WIASDGWGKQQKLLEGLE 323
             :::..|  :::....|.::.|   .|...:|...........||  ||.:..|
Mouse   257 -NTVNRKRFMERFSLTRVIIAF---GDTYSLLALPVHTTFYTTFHNVWITTSDW----------- 306

  Fly   324 DIA------------EGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLS 376
            ||.            .|.::...:.:.|..|..::..:.|....::.:..:.|...|.|...
Mouse   307 DITFYFQQPISYKYFGGGLSFSDRMDQILGFKDFLKNIQPRKYPQDIFIQDVWIILFECPYL--- 368

  Fly   377 VKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKT----QFVVDAVYAFAYALHNLHN 437
                       .|::  .:..::|:.:..||.:..:..:..|    ..|..||||.|.|||
Mouse   369 -----------IDHE--ARQLSQCEPNGSLSTRPLHVWDMNTSPYSSKVHAAVYAIAQALH---- 416

  Fly   438 DRCNTQSDQTTETRKHLQSESVWYRKISTD-TKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSE 501
            :..:.:.:..:..|..|::...|  |:... .|.|    :.....||       |:...::..:|
Mouse   417 EELSLRVEGGSLDRSALRAPLPW--KLHPFLQKGQ----LGRSSNKE-------NIVNKEILATE 468

  Fly   502 VKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKW------FNGLQLNSETVVWNKETEQ-PTSA 559
                        :||.|||..::.:..|.|| |::      .....:|.:.:.|.|..:. |.|.
Mouse   469 ------------FDIFNYQSLQSGTKAQVKV-GEFVFESHRVQHFSINEKLITWGKYGKGIPLSV 520

  Fly   560 CSLPCEVGMIKKQ-QGDT-CCWICDSCESFEYVYDE--FTCKDCGPGLWPYADKLSCYALDIQYM 620
            ||..|.:|..|.. :|.: ||:.|..|...|...|.  ..|..|....:|...|.:|......::
Mouse   521 CSQSCPLGFRKTPVEGKSFCCFDCLPCPEGEVANDTDMDQCIKCPEDQYPNKQKNNCLPKIKIFL 585

  Fly   621 KWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAK 685
            ........:.:::||...|.:::::.||....|||:|||:.|.|||.||..:::|:..:...|.:
Mouse   586 SHEDTLGAVLVSLAISLSAFSAMILGLFIHYRDTPIVRANNRNLSYVLLVSLMLCFFCSLIFIGQ 650

  Fly   686 PTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLK--YISPQSQVVITTSLIAI 748
            |:..:|||::...||.||:..||:|.||..:...| :|.|....|:  .::..|..::....| |
Mouse   651 PSTVTCVLRQMIFGVVFSVAVSAILAKTFIVVVAF-TAIKPGSTLQMWMVTRLSNAIVCCGSI-I 713

  Fly   749 QVLITMIWMVVEPPGTRFYYPDR------REVILKC-KIQDMSFLFSQLYNMILITICTIYAIKT 806
            ||.|..:|:...||     :||.      .::||.| :...::|.....|...|.::..:.|...
Mouse   714 QVCICAVWLGTYPP-----FPDADMHSEFGQIILWCNEGSTLAFYCVLGYLGFLSSLSLLIAFLA 773

  Fly   807 RKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKV 871
            |::||:|||:|.|.|:|...|.:|:.|||.|..:.....|....|  ||..|:|:.|:|::.||.
Mouse   774 RRLPESFNEAKTITFSMLVFCTVWITFVPTYLSSKGKTMVAVEIL--SILASSSILLLCIFLPKC 836

  Fly   872 YILVFHPDKNVRK 884
            |:::.....:.||
Mouse   837 YVILLRSGGHSRK 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	113/549 (21%)
		ANF_receptor	72..518	CDD:279440	96/477 (20%)
		NCD3G	557..604	CDD:284890	15/50 (30%)
		7tm_3	638..873	CDD:278433	78/243 (32%)
Vmn2r22	NP_001098107.1	PBP1_Pheromone_receptor	37..509	CDD:107360	114/556 (21%)
		ANF_receptor	82..394	CDD:279440	73/366 (20%)
		NCD3G	519..569	CDD:284890	15/49 (31%)
		7tm_3	604..838	CDD:278433	78/242 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000