Protein Alignment mGluR and Vmn2r43

DIOPT Version :10

• Sequence 1: NP_524639.2
• Gene: mGluR / 43838
• FlyBaseID: FBgn0019985
• Length: 976
• Species: Drosophila melanogaster
• Sequence 2: XP_017177811.1
• Gene: Vmn2r43 / 381838
• MGIID: 3037819
• Length: 861
• Species: Mus musculus
• Alignment Length: 877
• Identity: 193/877 - (22%)
• Similarity: 359/877 - (40%)
• Gaps: 183/877 - (20%)

  Fly    76 AMLYAIDRVNNDPNILPGITIGV-HILDTCSRDT-----YALNQSLQFVRASLNNLDTSGYECAD 134
            |:::::|.:|.:|::||.:::.: :.|..|...|     |.|::..|   :.:.|     |.|
Mouse    77 ALVFSMDEINRNPDLLPNMSLIIRYTLGRCDGKTGIPTPYLLHKKKQ---SPIPN-----YFC-- 131

  Fly   135 GSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIP---QVSPASTAKTLSDKTRFDLFAR 196
                    |..|...|.:.|.:: .|||...|.|..|..|   |::......|.||..::....:
Mouse   132 --------NEESMCSFLLTGPNW-EVSLSFWNFLDSFLSPRILQLTYGPFHSTFSDDEQYPYLYQ 187

  Fly   197 TVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDK 261
            ..|.||..::|:|..:..|||:::..:..:...|...:..|.|::..:.:|.|..:.:  :.||.
Mouse   188 MAPKDTSLALAMVSFIHYFNWNWIGLLIPDDDQGNQFLLELKKQSGNKKICFAFVKMI--SVDDI 250

  Fly   262 V----------------------------FDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRA 298
            :                            |..:|.::.:.|     ||       |||
Mouse   251 LLEQKTEMYYQQIVMSSSNVIIIYEETINFIDLIFRMWEPP-----VL-------RRI------- 296

  Fly   299 NLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADF-------------DRYMMQLT 350
                   ||.:..|.......:.......|::|.......|:.|             |.|::.
Mouse   297 -------WITTKQWNFPTSKRDITHGTFYGSLTFLPHRGGISGFKNFVQTWFHLRSKDLYLVM-- 352

  Fly   351 PETNQRNPW-FAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQ 414
            ||      | :.:|.....||.:..       |||:|::.:             :.:.:|.....
Mouse   353 PE------WKYFKYESLASNCKMLK-------SNSSNASFD-------------WLMEQKFDMAF 391

  Fly   415 ESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANY 479
            ...:..:.:|||..|:|||.::..:.:   :|..:..|...|..:   |:
Mouse   392 SESSHNIYNAVYVVAHALHEMNLQQVD---NQAVDNGKGASSHCL---KV--------------- 435

  Fly   480 DGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGK---WFN--- 538
                  |::|..:.|.:..|.:|...::......|||.:::......|.:.| :||   :|:
Mouse   436 ------NSFLRKIHFTNPVGDKVIMKQRVIMQEDYDIFHFENLSQHLGIKVK-LGKFSPYFSHGR 493

  Fly   539 GLQLNSETV-VWNKETEQPTSACSLPCEVGM--IKKQQGDTCCWICDSCE----SFEYVYDEFTC 596
            ...|..:.: |.....:.|:|.||..|..|.  :.|:....||::|..|.    |.|...|:  |
Mouse   494 NFHLYVDMLEVATGSRKMPSSVCSAECSPGFRRLWKEGMAACCFVCRPCPENEISNETNMDQ--C 556

  Fly   597 KDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASG 661
            .:|....:...::..|....:.::.:.....::...:|....|.|::|:.:|.|:||||:|:|:.
Mouse   557 VNCPEYQYANTEQNKCIKKGVTFLSYEDPLGMVLALMAFCFSAFTAVVLCVFVKHHDTPIVKANN 621

  Fly   662 RELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKS 726
            |.|||.||..::.|:..:|..|..|...:||||:...|:.|::..|.:|.||..:...| ..:..
Mouse   622 RILSYILLLSLMSCFLCSFFFIGHPNRATCVLQQITFGIVFTVAVSTVLAKTVTVVLAF-KVTDP 685

  Fly   727 AQRLKY--ISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR----EVILKCKIQDMSF 785
            .:||::  :|.....:|....: .|.::..||:.|.||   |...|..    .:|:.|....::.
Mouse   686 GRRLRHFLVSGTPNYIIPICSL-FQCVLCAIWLAVSPP---FVDIDEHSQHGHIIIVCNKGSVTA 746

  Fly   786 LFSQL-YNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTT 849
            .:..| |...|.....|.|...:.:|:.|||:||:.|:|.....:|:.|:|:|..|..  :|...
Mouse   747 FYCVLGYLACLALGSFIVAFLAKNLPDTFNEAKFLTFSMLVFFSVWVTFLPVYHSTKG--KVMVA 809

  Fly   850 TLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            ....||..|::..|.|:::||:||::..|::|
Mouse   810 VEIFSILASSAGMLGCIFAPKIYIILMRPERN 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_524639.2	PBP1_mGluR_groupII	39..542	CDD:380598	97/522 (19%)
		NCD3G	556..605	CDD:462210	16/54 (30%)
		7tmC_mGluRs_group2_3	625..876	CDD:320600	75/257 (29%)
		TM helix 1	625..650	CDD:320600	5/24 (21%)
		TM helix 2	662..683	CDD:320600	8/20 (40%)
		TM helix 3	692..716	CDD:320600	9/23 (39%)
		TM helix 4	738..758	CDD:320600	4/19 (21%)
		TM helix 5	781..807	CDD:320600	5/26 (19%)
		TM helix 6	815..838	CDD:320600	8/22 (36%)
		TM helix 7	845..870	CDD:320600	6/24 (25%)
Vmn2r43	XP_017177811.1	PBP1_pheromone_receptor	43..503	CDD:380588	98/528 (19%)
		NCD3G	512..565	CDD:462210	16/54 (30%)
		7tmC_V2R_pheromone	585..836	CDD:320410	75/257 (29%)
		TM helix 1	585..610	CDD:320410	5/24 (21%)
		TM helix 2	622..643	CDD:320410	8/20 (40%)
		TM helix 3	652..676	CDD:320410	9/23 (39%)
		TM helix 4	700..716	CDD:320410	2/16 (13%)
		TM helix 5	743..769	CDD:320410	5/25 (20%)
		TM helix 6	777..800	CDD:320410	8/22 (36%)
		TM helix 7	805..830	CDD:320410	6/24 (25%)