DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and grm2a

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_005166174.1	Gene:	grm2a / 336153	ZFINID:	ZDB-GENE-030131-8097	Length:	894	Species:	Danio rerio

Alignment Length:	923	Identity:	433/923 - (46%)
Similarity:	565/923 - (61%)	Gaps:	105/923 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 NTHTQDSVSVSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPG 93
            ||.|... .:.:.||:::|||||||.||||| .||.....||:|||||||.|:|::|.|..||||
Zfish    46 NTDTSKK-EIVMDGDLVIGGLFPVHHKGEGAQDCGRINTQRGIQRLEAMLLALDKINQDDQILPG 109

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGS------SPQLRKNASSGPVFGV 152
            :|:|.|||||||:|||||.|||:||||||..:|.|.|.|.|||      .|.        .:.||
Zfish   110 VTLGAHILDTCSKDTYALEQSLEFVRASLTKVDDSEYTCPDGSYAIHDDVPL--------AISGV 166

  Fly   153 IGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNW 217
            ||||||.||:|||||||||.|||:|.|||:..||||:|:|.||||||||.:|:.|:.:||:.|||
Zfish   167 IGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNW 231

  Fly   218 SYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLF 282
            :||||:.|||.|||.||:|..:||....:|||.:.||..:.|...:|.:|..|.:|.||:.|:||
Zfish   232 TYVSTVASEGDYGETGIDAFQQEARALQICIATSAKVSRSMDQYSYDGVIRSLLQKSNAKVVILF 296

  Fly   283 TRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMM 347
            ||:||||.:|.||||.|:|  |.|:||||||.|:.::.|.|.:|:||.|:||.|..|.:|..|..
Zfish   297 TRSEDARELLVAAKRMNVS--FIWVASDGWGAQEVVVRGSESVADGAFTIELASYTIPEFAAYFT 359

  Fly   348 QLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGY 412
            .|.|..|.|||||.|:||:.|.|.|..:     |....:..|.|                    :
Zfish   360 NLNPYNNTRNPWFREFWENKFQCSLHDI-----TCGKHSLRDGK--------------------F 399

  Fly   413 EQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMA 477
            |||||..|||:||||.|.|||::....|                        :..||  .|..|.
Zfish   400 EQESKIMFVVNAVYAMANALHHMRQALC------------------------ANSTK--LCSAMK 438

  Fly   478 NYDGKEFYNNYLLNVSF------IDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKW 536
            ..:||..|.:|:|...|      .| ..:.:.||..||.|.||:|.:|.::.:.  |.|:.:|.|
Zfish   439 PVNGKRLYKDYILKTKFDAPFRPAD-TDNIIHFDAYGDSLGRYNIFHYHKENDE--YVYRKVGYW 500

  Fly   537 FNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKKQQ-GDTCCWICDSCESFEYVYDEFTCKDCG 600
            ...|.||:..:.|..:. .|||.||.||....||..| ||.|||||..|:.::|:.|||||.||.
Zfish   501 AQDLTLNTTLIPWESQA-VPTSQCSDPCRKNEIKSMQPGDVCCWICIPCQPYQYLLDEFTCADCS 564

  Fly   601 PGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELS 665
            .|.||..:...||.|..:|:.|...:|:.|::||..|:..|..||.||.||::||:|:|||||||
Zfish   565 FGQWPLDNLTGCYDLPEEYIHWEDAWAIGPVSIACLGMLCTLFVIGLFLKNNETPVVKASGRELS 629

  Fly   666 YTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRL 730
            |.||.|:|:||..||..|:||:...|.|:|.|:|..|::.|||||||||||:|||:.....|||.
Zfish   630 YILLLGVLLCYFMTFIYISKPSAVVCTLRRLGLGTSFAVCYSALLTKTNRIARIFNGVKDGAQRP 694

  Fly   731 KYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTR-FYYPDRREVI-LKCKIQDMSFLFSQLYNM 793
            ::|||.|||.|..:||:.|:|:.::|::||.||.| ...|:||:|: |||..:|.|.|.|..||.
Zfish   695 RFISPASQVAICAALISCQLLVVVVWLLVEAPGVRKEVSPERRDVVTLKCNSKDSSMLMSLTYNC 759

  Fly   794 ILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLS 858
            :||.:||.||.||||.||||||:|||||||||||||||||.||::.|.:.|.|||||:|||:|||
Zfish   760 VLIILCTFYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFQPIFYVTASDYRVQTTTMCISVSLS 824

  Fly   859 ASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGG 923
            .||.|.||::||::|::|.|.|||..|.:.:|                 .:|.|..||:|.....
Zfish   825 GSVVLGCLFAPKIHIILFQPQKNVTTLRVATT-----------------RFSVTTGPGSSFSQAS 872

  Fly   924 AVGTNASSSTLPT 936
            |      |:.:||
Zfish   873 A------SNIVPT 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	234/511 (46%)
		ANF_receptor	72..518	CDD:279440	210/457 (46%)
		NCD3G	557..604	CDD:284890	26/47 (55%)
		7tm_3	638..873	CDD:278433	137/236 (58%)
grm2a	XP_005166174.1	PBP1_mGluR_groupII	58..508	CDD:107370	235/513 (46%)
		NCD3G	520..569	CDD:311495	26/48 (54%)
		7tm_GPCRs	589..842	CDD:333717	143/252 (57%)
		TM helix 1	590..614	CDD:320095	10/23 (43%)
		TM helix 2	626..647	CDD:320095	13/20 (65%)
		TM helix 3	656..678	CDD:320095	12/21 (57%)
		TM helix 4	704..720	CDD:320095	5/15 (33%)
		TM helix 5	747..770	CDD:320095	11/22 (50%)
		TM helix 6	779..804	CDD:320095	22/24 (92%)
		TM helix 7	811..836	CDD:320095	16/24 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580272
Domainoid	1	1.000	396	1.000	Domainoid score	I725
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	826	1.000	Inparanoid score	I449
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0003689
OrthoInspector	1	1.000	-	-		otm24465
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.940