DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Tas1r1

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_445757.1	Gene:	Tas1r1 / 29407	RGDID:	61891	Length:	840	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	235/914 - (25%)
Similarity:	399/914 - (43%)	Gaps:	143/914 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGAPC------------ 62
            :|.:.:|..|:.       |...|:.|...|||||.:|.|||.:|     ..|
  Rat     9 LLSLQLVYCWAF-------SCQRTESSPGFSLPGDFLLAGLFSLH-----GDCLQVRHRPLVTSC 61

  Fly    63 -GPKVYN-RGVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNL 125
             .|..:| .|....:||.:.::.:||...:||.||:|..:.|.||....        |.|:|..|
  Rat    62 DRPDSFNGHGYHLFQAMRFTVEEINNSSALLPNITLGYELYDVCSESAN--------VYATLRVL 118

  Fly   126 DTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTR 190
            ...|....: ....||.::|.  |...||...:..::..|.||..|.:|.||..:::..||.|.:
  Rat   119 ALQGPRHIE-IQKDLRNHSSK--VVAFIGPDNTDHAVTTAALLGPFLMPLVSYEASSVVLSAKRK 180

  Fly   191 FDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVP 255
            |..|.||||.|..|...:|.:|::|.|.::|.|.|.|.||:.|::||.:.|..|.:|:|..:.||
  Rat   181 FPSFLRTVPSDRHQVEVMVQLLQSFGWVWISLIGSYGDYGQLGVQALEELAVPRGICVAFKDIVP 245

  Fly   256 SAADDKVFD-SIISKLQKKPNARG--VVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQK 317
            .:|  :|.| .:.|.:|....||.  ||:|:....||...::...|||:... |:||:.|.....
  Rat   246 FSA--RVGDPRMQSMMQHLAQARTTVVVVFSNRHLARVFFRSVVLANLTGKV-WVASEDWAISTY 307

  Fly   318 L--LEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPD 380
            :  :.|::.|.. .:.|.:|...:                  |...|:.|.....|..:.|..|:
  Rat   308 ITSVTGIQGIGT-VLGVAVQQRQV------------------PGLKEFEESYVRAVTAAPSACPE 353

  Fly   381 TSNSANSTDNKIGVKAKTECDDSYRLSEK----VGYEQESKTQFVVDAVYAFAYALHNLHNDRCN 441
            .|..:.   |::       |.:.:..:.:    :|....|....|.:||||.|:.||.|..  |.
  Rat   354 GSWCST---NQL-------CRECHTFTTRNMPTLGAFSMSAAYRVYEAVYAVAHGLHQLLG--CT 406

  Fly   442 TQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDR 506
                                        |:.|.....|..:.....|  .|:|: |..:.|.||.
  Rat   407 ----------------------------SEICSRGPVYPWQLLQQIY--KVNFL-LHENTVAFDD 440

  Fly   507 QGDGLARYDILNYQRQENSSGYQYKVIGKWFNG---LQLNSETVVWN-KETEQPTSACSLPCEVG 567
            .||.|..|||:.:  ..|...:.:::||.....   |.:|...:.|: |..:.|.|.|:..|..|
  Rat   441 NGDTLGYYDIIAW--DWNGPEWTFEIIGSASLSPVHLDINKTKIQWHGKNNQVPVSVCTTDCLAG 503

  Fly   568 MIKKQQGD-TCCWICDSCE--SFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALI 629
            ..:...|. .||:.|..||  :|..:.:...|:.||...|...:..:|:...::::.|:...:|:
  Rat   504 HHRVVVGSHHCCFECVPCEAGTFLNMSELHICQPCGTEEWAPKESTTCFPRTVEFLAWHEPISLV 568

  Fly   630 PMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQ 694
            .:|.....:.|......|||.:..||:||::|..|.:.:|..::...|:.::...:||:.:|:|:
  Rat   569 LIAANTLLLLLLVGTAGLFAWHFHTPVVRSAGGRLCFLMLGSLVAGSCSFYSFFGEPTVPACLLR 633

  Fly   695 RFGIGVGFSIIYSALLTKTNRISRIFHSASKS-------AQRLKYISPQSQVVITTSLIAIQVLI 752
            :....:||:|..|.|..::.::..||..::|.       ||.    ......||.:|  .:.:||
  Rat   634 QPLFSLGFAIFLSCLTIRSFQLVIIFKFSTKVPTFYRTWAQN----HGAGLFVIVSS--TVHLLI 692

  Fly   753 TMIWMVV-EPPGTRFYYPDRREVILKC-KIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNE 815
            .:.|:|: .|..||.|......|||:| ::..:.||.:..:|::|.....:.:...:::|||:||
  Rat   693 CLTWLVMWTPRPTREYQRFPHLVILECTEVNSVGFLLAFTHNILLSISTFVCSYLGKELPENYNE 757

  Fly   816 SKFIGFTMYTTCIIWLAF---VPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFH 877
            :|.:.|::....:.|:||   ..||.|   ||......|....:||...:  ..:.||.|:::..
  Rat   758 AKCVTFSLLLNFVSWIAFFTMASIYQG---SYLPAVNVLAGLTTLSGGFS--GYFLPKCYVILCR 817

  Fly   878 PDKN 881
            |:.|
  Rat   818 PELN 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	135/524 (26%)
		ANF_receptor	72..518	CDD:279440	120/454 (26%)
		NCD3G	557..604	CDD:284890	14/49 (29%)
		7tm_3	638..873	CDD:278433	65/246 (26%)
Tas1r1	NP_445757.1	PBP1_Taste_receptor	31..485	CDD:107358	139/536 (26%)
		ANF_receptor	73..456	CDD:279440	120/460 (26%)
		NCD3G	493..543	CDD:284890	14/49 (29%)
		7tm_3	581..813	CDD:278433	64/242 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000