DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Gprc5b

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	XP_038963557.1	Gene:	Gprc5b / 293546	RGDID:	1309510	Length:	422	Species:	Rattus norvegicus

Alignment Length:	410	Identity:	90/410 - (21%)
Similarity:	167/410 - (40%)	Gaps:	101/410 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 TCKDCGPGLWPYADKLSCYALDIQYMK---WNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPL 656
            |.:.||..|.|            ||:.   .::::.::..|:|..|..:|.:::::....  .|.
  Rat    45 TSRGCGLDLLP------------QYVSLCDLDAIWGIVVEAVAGAGALITLLLMLILLVR--LPF 95

  Fly   657 VRASGRE----LSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRIS 717
            ::...|.    |.:..|.|.|..:..|||.|.:.....|.::||..||.|::.:|.||::..|:.
  Rat    96 IKDKERRRPVCLHFLFLLGTLGLFGLTFAFIIRMDETICSIRRFLWGVLFALCFSCLLSQAWRVR 160

  Fly   718 RIFHSASKSAQRLKYISPQSQVVITTS--LIAIQVLITMIWMVVEPPGTRFYYPDRREVILKCKI 780
            |:....:         ||.|..:::.:  |:.:||:|...|:|:..         .|:....|..
  Rat   161 RLVRQGT---------SPASWQLVSLALCLMLVQVIIATEWLVLTV---------LRDTKPACAY 207

  Fly   781 QDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESK----FIGFTMYTTCIIWLAFVPIYFGTG 841
            :.|.|:.:.:|:|:|:.|....::.|  :...|...|    ||..|.:.:.:||:.::.:|. .|
  Rat   208 EPMDFVMALIYDMVLLAITLAQSLFT--LCGKFKRWKVNGAFILITTFLSVLIWVIWMTMYL-FG 269

  Fly   842 NSYEVQT-----TTLCISISLSASVALVCLYSPKV-YILV----------------------FHP 878
            ||...:.     .||.|::..|..|.::....|:: |.|:                      |..
  Rat   270 NSLIKRADAWSDPTLAITLVASGWVFVIFHAIPEIHYTLLPPLQENPPNYFDTSQPRMRETAFEE 334

  Fly   879 DKNVRKLTMNSTVYR--------RSAAAVAQGA-----------PTSSGYSRTHAPGTSAL---T 921
            :.::.:..|.:..:.        |||...:.|:           |:|.| :|..||..|.:   |
  Rat   335 EMHLPRAYMENKAFSMDEHNAALRSAVGFSNGSLEQRSSSLGKKPSSLG-NRPSAPFRSNVYQPT 398

  Fly   922 GGAVGTNASSSTLPTQNSPH 941
            ..||..|  ..|:||....|
  Rat   399 EMAVVLN--GGTIPTAPPSH 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141
		ANF_receptor	72..518	CDD:279440
		NCD3G	557..604	CDD:284890	3/8 (38%)
		7tm_3	638..873	CDD:278433	57/250 (23%)
Gprc5b	XP_038963557.1	7tmC_RAIG2_GPRC5B	66..309	CDD:320405	61/265 (23%)
		TM helix 1	67..91	CDD:320405	4/23 (17%)
		TM helix 2	105..126	CDD:320405	7/20 (35%)
		TM helix 3	135..157	CDD:320405	8/21 (38%)
		TM helix 4	176..192	CDD:320405	4/15 (27%)
		TM helix 5	208..231	CDD:320405	6/22 (27%)
		TM helix 6	245..267	CDD:320405	5/21 (24%)
		TM helix 7	278..303	CDD:320405	5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910