DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vom2r11

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001092940.1	Gene:	Vom2r11 / 292417	RGDID:	1563778	Length:	864	Species:	Rattus norvegicus

Alignment Length:	914	Identity:	219/914 - (23%)
Similarity:	369/914 - (40%)	Gaps:	187/914 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVH-----EKGEGAPCGPKVYN----------RGVQRLEAMLYAIDRVNNDPNILP 92
            ||:::|..||||     .|...... |.:|.          :..|.:.|:.:||:.:|.:||:||
  Rat    39 GDLMIGAFFPVHTYYTVNKIPNVQF-PNIYYYQDYYLQFNFKNYQYVLALEFAIEEINRNPNLLP 102

  Fly    93 GITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSY 157
            .:|:|....:....:...|.....::.|.........|.|.:       ||.::     ...|:.
  Rat   103 NLTLGFDFYNVKFTEKETLMNVCMWLTAHKRGKVLPNYNCEE-------KNFTA-----AFTGTS 155

  Fly   158 SSVSLQVANLLRLFHIPQVS--PASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYV 220
            .:.|..:..||:||..||:|  |..||  |:|..::....:....||..|..:|.::..|.||:|
  Rat   156 WTTSAHIGTLLQLFRFPQLSIGPYDTA--LNDHGQYSSLYQMATKDTSLSHGIVSLMLYFRWSWV 218

  Fly   221 STIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQK-----KPNARGVV 280
            ..:..:...|...:.....|.....||||..:.:|:     .:....:|..|     :.::..|:
  Rat   219 GLLLPDDHKGNKVLSEFRDEMERERVCIAFVKMIPT-----TWTLYFNKQWKNMEEIEESSTNVI 278

  Fly   281 LFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGL-------EDIAEGA--------- 329
            :.....|:   ||...| |:.              |:||.|.       :||.:.|
  Rat   279 IIYGDVDS---LQGLMR-NIG--------------QRLLTGKVWVMNFEQDITDHADYFLLDSFH 325

  Fly   330 ---ITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNK 391
               |..:...|.. :|.:::..:.|.....:.:..:.|...|.|..:.:..|...:..||:|.|.
  Rat   326 GSFIFTQHYGESF-EFTKFIQTVNPYKYPEDIYLPKMWHYFFKCSYSEVDCKLLDNCQANATLNV 389

  Fly   392 IGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQS 456
            :.           |....|...:||..  :.:||||.|::||.:              |.|.:|
  Rat   390 LP-----------RHIFDVSMSKESYN--IYNAVYAVAHSLHEI--------------TLKQVQ- 426

  Fly   457 ESVWYRKISTDTKSQACPDMANYDGKE--FY----NNYLLNVSFIDLAGSEVKFDRQGDGL---- 511
                         .|.|.     :|:|  ||    |::|                |:..||
  Rat   427 -------------MQPCK-----NGEELLFYPWQINSFL----------------RKNMGLDWRQ 457

  Fly   512 ---ARYDILNYQRQENSSGYQYKVIGKWFNG------LQLNSETVVW-NKETEQPTSACSLPCEV 566
               ..|||||........|.:.| |||:...      |.|:.:.:.| .|.:|.|.|.||..|..
  Rat   458 KRNEEYDILNLWNFPKGLGLKIK-IGKYSENAPDGQQLTLSDQMIQWPEKFSEIPQSVCSESCGP 521

  Fly   567 GMIK-KQQGD-TCCWICDSCESFEY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFA 627
            |..| ..:|. .||:.|..|...|.  ..|...|..|....:...:|..|......::.:.....
  Rat   522 GFRKVTLEGQAVCCYNCTPCAENEISNETDVDHCVKCPESYYANTEKNHCLQKAQSFLAYEDPLG 586

  Fly   628 LIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCV 692
            :...:|::...|||.||:.:|.::..||:|:|:.|.||||||..:..|:..:...|.:|...:|:
  Rat   587 MALTSISLLFSALTVIVVGIFVRHRHTPMVKANNRALSYTLLISLNFCFLCSLNFIGQPNTATCI 651

  Fly   693 LQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYI----SPQSQVVITTSLIAIQVLIT 753
            ||:...||.|::..:.:|.|...:...| .|:...:.::::    :|...:.|.|   .||:::.
  Rat   652 LQQTIFGVAFTVALATVLAKAITVVIAF-KATFPGRIIRWLMISRAPNYTIPICT---LIQLVLC 712

  Fly   754 MIWMVVEPPGTRFY----YPDRREVILKC-KIQDMSFLFSQLYNMILITICTIYAIKTRKIPENF 813
            .|||...||   |.    :.:...||:.| |...::|..:..|...|.......|..:|.:|:.|
  Rat   713 GIWMATFPP---FVDQDDHTEHGHVIIFCNKGSSVAFHCALGYLCFLALGSYAMAFFSRNLPDTF 774

  Fly   814 NESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALV-CLYSPKVYILVFH 877
            |||||:.|:|.....:|:.|:|:|..|.....:.....||   |::|.||: .:::||.||::..
  Rat   775 NESKFLSFSMLVFFCVWITFLPVYHSTKGKIMLAMEVFCI---LASSAALLGFIFTPKCYIILLR 836

  Fly   878 PDKN 881
            |:||
  Rat   837 PEKN 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	119/558 (21%)
		ANF_receptor	72..518	CDD:279440	101/484 (21%)
		NCD3G	557..604	CDD:284890	15/50 (30%)
		7tm_3	638..873	CDD:278433	72/244 (30%)
Vom2r11	NP_001092940.1	PBP1_Pheromone_receptor	39..503	CDD:107360	120/565 (21%)
		ANF_receptor	85..468	CDD:279440	101/482 (21%)
		NCD3G	512..563	CDD:284890	15/50 (30%)
		7tm_3	598..832	CDD:278433	72/243 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000