DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vom2r10

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001092939.1	Gene:	Vom2r10 / 292414	RGDID:	1565464	Length:	858	Species:	Rattus norvegicus

Alignment Length:	906	Identity:	217/906 - (23%)
Similarity:	373/906 - (41%)	Gaps:	163/906 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GDIILGGLFPVHE--KGEGAPCGPKV----------YN-RGVQRLEAMLYAIDRVNNDPNILPGI 94
            |||::|..||:|.  .|:..| .|.:          || |..|.:.|:|:||:.:|.:||:||.|
  Rat    40 GDIVIGAFFPLHTFYTGKKMP-DPTLPYQYLDNYIQYNFRNYQYILALLFAIEEINGNPNLLPNI 103

  Fly    95 TIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSS 159
            ::|....:....:...|..::.::.|.:.......|.|.       :|..|:     .:.|:..:
  Rat   104 SLGFDFYNVRFTEKETLMNAVIWLTAHVQRKVLPNYNCK-------KKKFSA-----ALTGTSWT 156

  Fly   160 VSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIH 224
            .|.|:..||:||..||::.......|||..::....:..|.||..|:|:|.::..|.||:|..|.
  Rat   157 TSAQIGTLLQLFKFPQITFGPYDPLLSDHGQYSSLYQMAPKDTSLSLAIVSLMVYFRWSWVGLIL 221

  Fly   225 SEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAEDA- 288
            .:...|...:....:|...:.||||..:.:|:     .:.|...:..:..|...|::.....|:
  Rat   222 PDDHKGNKILSDYREEMERQRVCIAFVKMIPA-----TWTSYFPRFWENMNETNVIIIHGDIDSL 281

  Fly   289 ----RRILQAAKRANLSQPFHWIA---------SDGWGKQQKLLEGLEDIAEGAITVELQSEIIA 340
                |.|.|.....|:     |:.         ||.:         :.|...|::..:.......
  Rat   282 ESLLRNIGQRLLTRNV-----WVMNIERHVTEFSDYF---------MLDSFHGSLIFKHNYREKF 332

  Fly   341 DFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYR 405
            :|.:::..:.|.....:.:..:.|...|.|..        :..:....||         |..:..
  Rat   333 EFTKFIQTVNPNRYPEDIYLPKLWNLLFKCSF--------SDRNCQVLDN---------CQTNAS 380

  Fly   406 LS------EKVGYEQESKTQFVVDAVYAFAYALHN--LHNDRCNTQSDQTTETRKHLQSESV--- 459
            |.      ..|...:||.:  :.:.|||.|::||:  ||.          .:.|.:...|.:
  Rat   381 LDILPSHIFDVAMSEESIS--IYNGVYAVAHSLHDMRLHQ----------VQMRPYENGEGMIFI 433

  Fly   460 -WYRKISTDTKSQACPDMANYDGKEFYNNYLLN-VSFIDLAGSEVKFDRQGDGLARYDILNYQRQ 522
             |  :::|..|     |:      |..:|..|| :..||               |.|||||....
  Rat   434 PW--QLNTFLK-----DL------EVRDNRSLNWIQTID---------------AEYDILNLWNL 470

  Fly   523 ENSSGYQYKVIGKWFNG-----LQLNSETVVWNK-ETEQPTSACSLPCEVGM--IKKQQGDTCCW 579
            ....|.:.|:.....|.     |.|:.:.:.|.: .::.|.|.||..|..|.  :..:....||:
  Rat   471 PKGLGLKVKIGSFSANAPKGQQLSLSEQIIQWPEIFSKVPQSVCSESCGPGFRKVTLEGKPICCY 535

  Fly   580 ICDSCESFEY--VYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTS 642
            .|..|...|.  ..|...|..|....:|..:|.:||.....::.:.....:...:||:...|||:
  Rat   536 KCTPCAENEISNETDSDQCVRCPESHYPNTEKSNCYQKTSSFLAFEEPLGMALASIALCLSALTA 600

  Fly   643 IVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYS 707
            .||.:|.|..|||:|:|:.:.|||.||..:..|:..:...|.:|...:|:||:...||.|::..:
  Rat   601 FVIGIFVKYRDTPIVKANNQALSYILLITLKFCFLCSLNFIGQPNTAACILQQTTFGVAFTVALA 665

  Fly   708 ALLTKTNRISRIFHSASKSAQRLKYI----SPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFY- 767
            .:|.|...:...| ..|...:.::::    .|...|.|.|   .||:|:..|||.:.||   |.
  Rat   666 TVLAKAITVVLAF-KVSFPGRMVRWLMISRGPYYIVPICT---LIQLLLCGIWMTMSPP---FID 723

  Fly   768 ---YPDRREVILKCKIQDMSFLFSQLYNMILITICTIY--AIKTRKIPENFNESKFIGFTMYTTC 827
               :.:...:|:.|. :..|..|..:...:.:.....|  |..:|.:|:.||||||:..:|....
  Rat   724 QDPHTEHGHIIILCN-KGSSLAFHAVLGYLCLLALGSYTMAFLSRNLPDTFNESKFLSLSMLVFF 787

  Fly   828 IIWLAFVPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKN----VRK 884
            .:|:.|:|:|:.|..  :|.......||..|::..|..::.||.||::..||||    |||
  Rat   788 CVWVTFLPVYYSTKG--KVMVAMEVFSILASSTALLAFIFGPKCYIILLRPDKNSFNHVRK 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	116/543 (21%)
		ANF_receptor	72..518	CDD:279440	97/472 (21%)
		NCD3G	557..604	CDD:284890	13/50 (26%)
		7tm_3	638..873	CDD:278433	70/244 (29%)
Vom2r10	NP_001092939.1	PBP1_Pheromone_receptor	40..502	CDD:107360	117/550 (21%)
		NCD3G	511..562	CDD:284890	13/50 (26%)
		7tm_3	597..831	CDD:278433	70/243 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000