DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and GRM8

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001358015.1	Gene:	GRM8 / 2918	HGNCID:	4600	Length:	928	Species:	Homo sapiens

Alignment Length:	921	Identity:	428/921 - (46%)
Similarity:	560/921 - (60%)	Gaps:	76/921 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 THTQD-SVSVSLPGDIILGGLFPVHEKGE-GAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPG 93
            ||:|: :.|:.:.||||||||||||.||| |.|||.....:|:.||||||||||::|.||::|..
Human    31 THSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSN 95

  Fly    94 ITIGVHILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYS 158
            ||:||.||||||||||||.|||.||:|.:.. |.|..:||:|..|...|   ...:.||||.:.|
Human    96 ITLGVRILDTCSRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTK---PDKISGVIGAAAS 156

  Fly   159 SVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTI 223
            |||:.|||:||||.|||:|.||||..|||.||:|.|:|.||||::|:.|:|||:....|:||||:
Human   157 SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTL 221

  Fly   224 HSEGSYGEYGIEALHKEATE-RNVCIAVAEKVPSAADDKVFDSIISKLQKKPNARGVVLFTRAED 287
            .|||:|||.|:||..:.:.| ..||||.::|:|.......|:.||.:|.:.||||.|::|...:|
Human   222 ASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDD 286

  Fly   288 ARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPE 352
            .||||:|||:.|.|..|.||.||.||.:...:...|:|||||:|:..:...|..||||....|..
Human   287 IRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLA 351

  Fly   353 TNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESK 417
            .|:||.||||:||:.|.|.|.|       ....||...|        |....|::....||||.|
Human   352 NNRRNVWFAEFWEENFGCKLGS-------HGKRNSHIKK--------CTGLERIARDSSYEQEGK 401

  Fly   418 TQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGK 482
            .|||:||||:.||||||:|.|.|.....                          .||.|:..|||
Human   402 VQFVIDAVYSMAYALHNMHKDLCPGYIG--------------------------LCPRMSTIDGK 440

  Fly   483 EFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETV 547
            |.. .|:..|:|...||:.|.|:..||...||||..||....|:  :|||||.|.|.|.|..|.:
Human   441 ELL-GYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKST--EYKVIGHWTNQLHLKVEDM 502

  Fly   548 VW-NKETEQPTSACSLPCEVGMIKKQ-QGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKL 610
            .| ::|...|.|.|||||:.|..||. :|..|||.|:.||.:.|..||.:|:.|.....|..::.
Human   503 QWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRT 567

  Fly   611 SCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVC 675
            .|..:.|..::|:|.:|::|:.:||.||..|:.|||.|.:.:|||:||||||||||.||.||.:|
Human   568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLC 632

  Fly   676 YCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVV 740
            |..||.:||.|....|..:|..:|:|....|:|||||||||.|||....||....|:|||.||:|
Human   633 YSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLV 697

  Fly   741 ITTSLIAIQVLITMIWMVVEPPGTRFYY-------PDRREVILKCKIQDMSFLFSQLYNMILITI 798
            ||.|||::|:|...:|.||:||.....|       |::...:|||.|.|:|.:.|..|:::|:..
Human   698 ITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVT 762

  Fly   799 CTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---VQTTTLCISISLSAS 860
            ||:||||||.:||.|||:|.|||||||||||||||:||:|||..|.|   :|||||.:|:|||||
Human   763 CTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSAS 827

  Fly   861 VALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSS-----GYSRTHAPGTSAL 920
            |:|..||.|||||::|||::||:|       .:||..||...|...|     |..|.:....|.|
Human   828 VSLGMLYMPKVYIIIFHPEQNVQK-------RKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSEL 885

  Fly   921 TGGAVGTNASS 931
            . .::.||:|:
Human   886 C-ESLETNSST 895

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	234/500 (47%)
		ANF_receptor	72..518	CDD:279440	203/446 (46%)
		NCD3G	557..604	CDD:284890	21/47 (45%)
		7tm_3	638..873	CDD:278433	133/244 (55%)
GRM8	NP_001358015.1	PBP1_mGluR_groupIII	40..504	CDD:380599	236/511 (46%)
		Glutamate binding. /evidence=ECO:0000250	177..179		1/1 (100%)
		NCD3G	512..562	CDD:369426	22/49 (45%)
		7tmC_mGluR8	582..892	CDD:320570	156/317 (49%)
		TM helix 1	583..607	CDD:320570	11/23 (48%)
		TM helix 2	619..640	CDD:320570	13/20 (65%)
		TM helix 3	649..671	CDD:320570	9/21 (43%)
		TM helix 4	697..713	CDD:320570	8/15 (53%)
		TM helix 5	745..768	CDD:320570	8/22 (36%)
		TM helix 6	777..802	CDD:320570	21/24 (88%)
		TM helix 7	812..837	CDD:320570	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11921
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820