DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and GRM7

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_870989.1	Gene:	GRM7 / 2917	HGNCID:	4599	Length:	922	Species:	Homo sapiens

Alignment Length:	951	Identity:	435/951 - (45%)
Similarity:	569/951 - (59%)	Gaps:	113/951 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 SVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQRLEAMLYAIDRVNNDPNILPGITIGVHIL 101
            |:.:.||:.||||||||.|| .|.|||......|:.||||||||:|::|:|||:||.:|:|..||
Human    42 SIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARIL 106

  Fly   102 DTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVAN 166
            ||||||||||.|||.||:|.:.. |||...|.:|..|...|...   |.||||.|.||||:.|||
Human   107 DTCSRDTYALEQSLTFVQALIQK-DTSDVRCTNGEPPVFVKPEK---VVGVIGASGSSVSIMVAN 167

  Fly   167 LLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGE 231
            :||||.|||:|.||||..|||..|:|.|:|.||||:||:.|:|||:|...|:||||:.|||||||
Human   168 ILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGE 232

  Fly   232 YGIEA---LHKEATERNVCIAVAEKVPSAADDKV--FDSIISKLQKKPNARGVVLFTRAEDARRI 291
            .|:|:   :.|||  ..:|||.:.::|....|:.  ||.||.:|...||:|.||:|...||.::|
Human   233 KGVESFTQISKEA--GGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQI 295

  Fly   292 LQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQR 356
            |.|||||:....|.|:.||.||.:...|...|||||||||::.:...:..||.|....|.|.|:|
Human   296 LAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR 360

  Fly   357 NPWFAEYWEDTFNCVLT-SLSVKPDTSNSANSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQF 420
            |.|||||||:.|||.|| |.|.|.|       ||.|        |....|:.:...||||.|.||
Human   361 NVWFAEYWEENFNCKLTISGSKKED-------TDRK--------CTGQERIGKDSNYEQEGKVQF 410

  Fly   421 VVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEFY 485
            |:|||||.|:|||:::.|.|   :|               ||.:        ||:|....||:..
Human   411 VIDAVYAMAHALHHMNKDLC---AD---------------YRGV--------CPEMEQAGGKKLL 449

  Fly   486 NNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWN 550
             .|:.||:|...||:.|.|::.||...||||..|| ..|:|...|::||:|.:.||||.|.:.|.
Human   450 -KYIRNVNFNGSAGTPVMFNKNGDAPGRYDIFQYQ-TTNTSNPGYRLIGQWTDELQLNIEDMQWG 512

  Fly   551 KET-EQPTSACSLPCEVGMIKK-QQGDTCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCY 613
            |.. |.|.|.|:|||:.|..|| |:|..|||.|:.|:.::|.:||.||:.|.....|..::..|.
Human   513 KGVREIPASVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQ 577

  Fly   614 ALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCN 678
            .:.|..::|:|.:|:||:.:|:.||..|..|:..|.:.:|||:||||||||||.||.||.:||..
Human   578 DIPIIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYII 642

  Fly   679 TFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITT 743
            ||.:||||.:..|..:|..:|:|..|.|:|||||||||.|||....||....:.|||.||:.||:
Human   643 TFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITS 707

  Fly   744 SLIAIQVLITMIWMVVEPPGTRFYY-------PDRREVILKCKIQDMSFLFSQLYNMILITICTI 801
            |||::|:|...||..|:||.....|       |::...:|||.|.|:..:.|..|:::|:..||:
Human   708 SLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTV 772

  Fly   802 YAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYE---VQTTTLCISISLSASVAL 863
            ||||||.:||||||:|.||||||||||:||||:||:|||..|.|   :|||||.||::|||||||
Human   773 YAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVAL 837

  Fly   864 VCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQGAPTSSGYSRTHAPGTSALTGGAVGTN 928
            ..||.|||||::|||:.||:|       .:||..||...|..||..|  |.|
Human   838 GMLYMPKVYIIIFHPELNVQK-------RKRSFKAVVTAATMSSRLS--HKP------------- 880

  Fly   929 ASSSTLPTQNSPHLDEASAQTNVAHKTNGEFLPEVGERVEP 969
                                   :.:.|||...|:.|.|:|
Human   881 -----------------------SDRPNGEAKTELCENVDP 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	239/505 (47%)
		ANF_receptor	72..518	CDD:279440	213/451 (47%)
		NCD3G	557..604	CDD:284890	21/47 (45%)
		7tm_3	638..873	CDD:278433	131/244 (54%)
GRM7	NP_870989.1	PBP1_mGluR_groupIII	47..511	CDD:107371	243/512 (47%)
		ANF_receptor	77..484	CDD:279440	215/455 (47%)
		Glutamate binding. /evidence=ECO:0000250	180..182		1/1 (100%)
		NCD3G	521..567	CDD:284890	21/45 (47%)
		7tm_3	602..847	CDD:278433	131/244 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	874..895		8/58 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820