DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and GRM6

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_000834.2	Gene:	GRM6 / 2916	HGNCID:	4598	Length:	877	Species:	Homo sapiens

Alignment Length:	906	Identity:	396/906 - (43%)
Similarity:	540/906 - (59%)	Gaps:	76/906 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ILVVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKG-EGAPCGPKVYNRGVQR 73
            :||.::.|:|.....|...:.       ||.|.|.:.||||||||.:| .|..||.....:||.|
Human    11 LLVALLPLAWLAQAGLARAAG-------SVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHR 68

  Fly    74 LEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLNNL---DTSGYECADG 135
            |||||||:||||.||.:|||:.:|..:|||||||||||.|:|.||:|.:...   |..|..| .|
Human    69 LEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRC-PG 132

  Fly   136 SSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFARTVPP 200
            ..|.||. |....|..|:|.|.||||:.|||:||||.|||:|.||||..|||.||:|.|:|.|||
Human   133 GVPPLRP-APPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPP 196

  Fly   201 DTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATER-NVCIAVAEKVPSAADDKVFD 264
            |::|:.|:|||::...|:||||:.|||:|||.|:||..:.:.|. .||||.:.|:|.......|.
Human   197 DSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFS 261

  Fly   265 SIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDIAEGA 329
            .:|.:|.:.|||||:::|...:|.||:|:||::|||:..|.|:.||.||.:...:..|||:|.||
Human   262 KVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGA 326

  Fly   330 ITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDNKIGV 394
            ||:..:...|..||:|.|..:.|.|:||.||||:||:.|||.|||...:.|.|.
Human   327 ITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDST----------- 380

  Fly   395 KAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTETRKHLQSESV 459
               .:|....|:.....||||.|.|||:|||||.|:|||::|...|...:.
Human   381 ---RKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTG-------------- 428

  Fly   460 WYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQR--- 521
                        .||.|...||:... .|:..|.|...||:.|.|:..||...||||..||.
Human   429 ------------LCPAMEPTDGRMLL-QYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNG 480

  Fly   522 QENSSGYQYKVIGKWFNGLQLNSETVVWNKET-EQPTSACSLPCEVGMIKKQ-QGDTCCWICDSC 584
            ..:|.|||  .:|:|...|:|:.|.:.|:.:. |.|:|.|||||..|..||. :|..|||.|::|
Human   481 SASSGGYQ--AVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEAC 543

  Fly   585 ESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSIVIVLFA 649
            :.:.:..|||||:.|...:.|..:...|....:..:.|:|.:|..|:.:|:.||..|:.|:..|.
Human   544 DGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFV 608

  Fly   650 KNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTN 714
            :.::||:||||||||||.||.||.:.|..||.::|:|....|..:|..:|:|.::.|||||||||
Human   609 RYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTN 673

  Fly   715 RISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRREV----- 774
            ||.|||....:|.....:|||.||:|||.||.::||:..:.|:...||.:...|.::|.|
Human   674 RIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQA 738

  Fly   775 --ILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIY 837
              :|||.:.|:|.:....|:::|:..||:||||.|.:||.|||:|.||||||||||||||||||:
Human   739 RGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIF 803

  Fly   838 FGTGNSYE---VQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRK----LTMNSTV 891
            |||..|.|   :|||||.:|:||||||:|..||.||.|:::|||::||:|    |...|||
Human   804 FGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTV 864

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	221/506 (44%)
		ANF_receptor	72..518	CDD:279440	197/449 (44%)
		NCD3G	557..604	CDD:284890	21/47 (45%)
		7tm_3	638..873	CDD:278433	122/244 (50%)
GRM6	NP_000834.2	Periplasmic_Binding_Protein_Type_1	45..506	CDD:299141	218/505 (43%)
		ANF_receptor	67..476	CDD:279440	197/451 (44%)
		Glutamate binding. /evidence=ECO:0000250	175..177		1/1 (100%)
		NCD3G	515..562	CDD:284890	21/46 (46%)
		7tm_3	597..842	CDD:278433	122/244 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	856..877		4/9 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X509
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.930