DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and GRM5

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001137303.1	Gene:	GRM5 / 2915	HGNCID:	4597	Length:	1212	Species:	Homo sapiens

Alignment Length:	972	Identity:	377/972 - (38%)
Similarity:	541/972 - (55%)	Gaps:	96/972 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LVVVMVLSWSRVVDLKSPSNTHTQDS---VSVSLPGDIILGGLFPVHEKGEGAPCGPKVYNR--- 69
            :|::::||   |:.||.......|.|   |...:|||||:|.||.||.:    |...||:.|
Human     1 MVLLLILS---VLLLKEDVRGSAQSSERRVVAHMPGDIIIGALFSVHHQ----PTVDKVHERKCG 58

  Fly    70 ------GVQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASL-NNLDT 127
                  |:||:||||:.::|:|:||.:||.||:|..|.|:|.....||.||::|:|.|| ::.:.
Human    59 AVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEE 123

  Fly   128 SG-YECADGSSPQLRKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRF 191
            .| ..|.||||...|   |..|:.||||...|||::||.|||:||:|||::.::|:..|||||.|
Human   124 EGLVRCVDGSSSSFR---SKKPIVGVIGPGSSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLF 185

  Fly   192 DLFARTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPS 256
            ..|.|.||.|..|:.|:|||:|.:||:|||.:|:||:|||.|:||....:.:..:|||.:.|:.|
Human   186 KYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYS 250

  Fly   257 AADDKVFDSIISKLQKK-PNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLE 320
            .|.::.||.::.||... |.||.|..|......|.:|.|.:|..|:..|..:.||||..:..:.:
Human   251 NAGEQSFDKLLKKLTSHLPKARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTD 315

  Fly   321 GLEDIAEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSA 385
            |.:..|.|.||::|||..:..||.|.::|.||||.|||||.|:|:..|.|.|...   |..::..
Human   316 GYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGF---PQENSKY 377

  Fly   386 NSTDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRCNTQSDQTTET 450
            |.|           |:.|  |:.|..:.|:||..||::|:|:.||.|||:....|...:.
Human   378 NKT-----------CNSS--LTLKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAG----- 424

  Fly   451 RKHLQSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDLAGSEVKFDRQGDGLARYD 515
                                 .|..|...||::...: |:..:|..::|..:.||..||...||:
Human   425 ---------------------LCDAMKPIDGRKLLES-LMKTNFTGVSGDTILFDENGDSPGRYE 467

  Fly   516 ILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKETEQPTSACSLPCEVGMIKK-QQGD-TCC 578
            |:|: ::.....:.|..:|.|.||.....:..||:|::....|.||.|||.|.||. ::|: :||
Human   468 IMNF-KEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEKGQIKVIRKGEVSCC 531

  Fly   579 WICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIALTSI 643
            |.|..|:..|||:||:|||.|..|.||..|...|..:.:||::|.....:..:..|..|:..|..
Human   532 WTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLF 596

  Fly   644 VIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSA 708
            |.|:|....|||:|::|.|||.|.:|.||.:.|..||.|||||....|.|||.|||:..::.|||
Human   597 VTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSA 661

  Fly   709 LLTKTNRISRIFHSASKS--AQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDR 771
            |:||||||:||...:.|.  .::.:::|..:|:||...||.||:.|.:...::|||.....||..
Human   662 LVTKTNRIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSI 726

  Fly   772 REVILKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPI 836
            |||.|.|...::..:....||.:||..||.||.|||.:|.||||:|:|.||||||||||||||||
Human   727 REVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPI 791

  Fly   837 YFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAAVAQ 901
            ||  |::|::  .|:|.|:||||:|||.|::.|||||::..|::|||.....|||.|..
Human   792 YF--GSNYKI--ITMCFSVSLSATVALGCMFVPKVYIILAKPERNVRSAFTTSTVVRMH------ 846

  Fly   902 GAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPTQNSPHLDEASAQTNVAHKTNGE-FLPE 962
               ...|.|.:.|..:|:|........:|..||     .:.|...||    ||:..| |.|:
Human   847 ---VGDGKSSSAASRSSSLVNLWKRRGSSGETL-----RYKDRRLAQ----HKSEIECFTPK 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	189/510 (37%)
		ANF_receptor	72..518	CDD:279440	169/448 (38%)
		NCD3G	557..604	CDD:284890	25/48 (52%)
		7tm_3	638..873	CDD:278433	115/236 (49%)
GRM5	NP_001137303.1	PBP1_mGluR_groupI	26..497	CDD:107369	191/521 (37%)
		ANF_receptor	67..472	CDD:279440	170/451 (38%)
		NCD3G	508..557	CDD:284890	25/48 (52%)
		7tm_3	591..824	CDD:278433	115/236 (49%)
		GluR_Homer-bdg	1162..1212	CDD:287563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820