DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and GRM2

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_000830.2	Gene:	GRM2 / 2912	HGNCID:	4594	Length:	872	Species:	Homo sapiens

Alignment Length:	948	Identity:	441/948 - (46%)
Similarity:	590/948 - (62%)	Gaps:	111/948 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 GTIL-VVVMVLSWSRVVDLKSPSNTHTQDSVSVSLPGDIILGGLFPVHEKGEGA-PCGPKVYNRG 70
            |::| ::.::|.|..|.:  .|:..      .::|.||::||||||||:||..| .|||...:||
Human     2 GSLLALLALLLLWGAVAE--GPAKK------VLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRG 58

  Fly    71 VQRLEAMLYAIDRVNNDPNILPGITIGVHILDTCSRDTYALNQSLQFVRASLN-NLDTSGYECAD 134
            :|||||||:|:||:|.||::|||:.:|.||||:||:||:||.|:|.||||||: ..|.|.:.|.|
Human    59 IQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPD 123

  Fly   135 GSSPQLRKNASSG----PVFGVIGGSYSSVSLQVANLLRLFHIPQVSPASTAKTLSDKTRFDLFA 195
            ||      .|:.|    .:.||||||||.||:|||||||||.|||:|.|||:..||||:|:|.||
Human   124 GS------YATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFA 182

  Fly   196 RTVPPDTFQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVAEKVPSAADD 260
            ||||||.||:.|:.:||:.|||:||||:.|||.|||.||||...||..||:|:|.:|||..|...
Human   183 RTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSR 247

  Fly   261 KVFDSIISKLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHWIASDGWGKQQKLLEGLEDI 325
            ..|:.::..|.:||:||..|||||:||||.:|.|::|.|.|  |.|:||||||..:.::.|.|..
Human   248 AAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGA 310

  Fly   326 AEGAITVELQSEIIADFDRYMMQLTPETNQRNPWFAEYWEDTFNCVLTSLSVKPDTSNSANSTDN 390
            ||||||:||.|..|:||..|...|.|..|.|||||.|:||..|.|   |...:...::|..:
Human   311 AEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRC---SFRQRDCAAHSLRA--- 369

  Fly   391 KIGVKAKTECDDSYRLSEKVGYEQESKTQFVVDAVYAFAYALHNLHNDRC-NTQSDQTTETRKHL 454
                               |.:|||||..|||:||||.|:||||:|...| ||
Human   370 -------------------VPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT------------ 403

  Fly   455 QSESVWYRKISTDTKSQACPDMANYDGKEFYNNYLLNVSFIDL------AGSEVKFDRQGDGLAR 513
                           ::.|..|...:|:..|.:::|||.| |.      ..:||:|||.|||:.|
Human   404 ---------------TRLCDAMRPVNGRRLYKDFVLNVKF-DAPFRPADTHNEVRFDRFGDGIGR 452

  Fly   514 YDILNYQRQENSSGYQYKVIGKWFNGLQLNSETVVWNKET--EQPTSACSLPCEVGMIKK-QQGD 575
            |:|..|.| ..|..|:|:.:|.|..||.|::..:.|...:  ..|.|.||.||....:|. |.|:
Human   453 YNIFTYLR-AGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGE 516

  Fly   576 TCCWICDSCESFEYVYDEFTCKDCGPGLWPYADKLSCYALDIQYMKWNSLFALIPMAIAIFGIAL 640
            .|||:|..|:.:||..|||||.|||.|.||.|....|:.|..:|::|...:|:.|:.||..|...
Human   517 VCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALA 581

  Fly   641 TSIVIVLFAKNHDTPLVRASGRELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSII 705
            |..|:.:|.:::.||:|:||||||.|.||.|:.:|||.||..||||:...|.|:|.|:|..||:.
Human   582 TLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVC 646

  Fly   706 YSALLTKTNRISRIFHSASKSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGT-RFYYP 769
            |||||||||||:|||..|.:.|||.::|||.|||.|..:||:.|:||.:.|:|||.||| :...|
Human   647 YSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAP 711

  Fly   770 DRREVI-LKCKIQDMSFLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAF 833
            :||||: |:|..:|.|.|.|..||::||.:||:||.||||.||||||:|||||||||||||||||
Human   712 ERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAF 776

  Fly   834 VPIYFGTGNSYEVQTTTLCISISLSASVALVCLYSPKVYILVFHPDKNVRKLTMNSTVYRRSAAA 898
            :||::.|.:.|.|||||:|:|:|||.||.|.||::||::|::|.|.|||
Human   777 LPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNV---------------- 825

  Fly   899 VAQGAPTSSGYSRTHAPGTSALTGGAVGTNASSSTLPT 936
            |:..||||...|      .:|....::|..:.|..:||
Human   826 VSHRAPTSRFGS------AAARASSSLGQGSGSQFVPT 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	242/511 (47%)
		ANF_receptor	72..518	CDD:279440	215/457 (47%)
		NCD3G	557..604	CDD:284890	24/47 (51%)
		7tm_3	638..873	CDD:278433	136/236 (58%)
GRM2	NP_000830.2	PBP1_mGluR_groupII	30..480	CDD:107370	242/511 (47%)
		ANF_receptor	60..456	CDD:279440	214/456 (47%)
		NCD3G	498..545	CDD:284890	24/46 (52%)
		7tm_3	579..816	CDD:278433	136/236 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146821
Domainoid	1	1.000	406	1.000	Domainoid score	I711
eggNOG	1	0.900	-	-		E33208_3B9DN
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	827	1.000	Inparanoid score	I465
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49358
OrthoDB	1	1.010	-	-		D1154468at2759
OrthoFinder	1	1.000	-	-		FOG0003689
OrthoInspector	1	1.000	-	-		otm40717
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2555
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.800