DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mGluR and Vom2r30

DIOPT Version :9

Sequence 1:	NP_001259076.1	Gene:	mGluR / 43838	FlyBaseID:	FBgn0019985	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_001092937.1	Gene:	Vom2r30 / 289295	RGDID:	1561133	Length:	849	Species:	Rattus norvegicus

Alignment Length:	877	Identity:	208/877 - (23%)
Similarity:	357/877 - (40%)	Gaps:	188/877 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 MLYAIDRVNNDPNILPGITIGV-HILDTCSRDTYALNQSLQFVRASLNNLDTSGYECADGSSPQL 140
            :.::::.:|.:|::||.:::.: |.|..|...|..     ..|:....| ....|.|
  Rat    78 LAFSMNEINRNPDLLPNMSLVIKHTLSYCDGKTVH-----HIVKEKFYN-PLPNYIC-------- 128

  Fly   141 RKNASSGPVFGVIGGSYSSVSLQVANLLRLFHIP---QVSPASTAKTLSDKTRFDLFARTVPPDT 202
              |..:...|.:.|.::.| |:::...|.:|..|   |:|........||..:|....:..|.||
  Rat   129 --NEETMCSFLLTGLNWIS-SIKLFRELDVFLFPRFLQISYGPFHSIFSDNEQFPYVYQMTPKDT 190

  Fly   203 FQSVALVDILKNFNWSYVSTIHSEGSYGEYGIEALHKEATERNVCIAVA---------------- 251
            ...:|:|.|:..|||::|..:.|:...|...:..|.||...:.:|.|..
  Rat   191 LLPLAMVSIIHYFNWNWVGLVISDNDEGNQFLSELKKETQTKEICFAFVTMMTINDLSSYHKTEM 255

  Fly   252 ---EKVPSAADDKVF----DSIIS---KLQKKPNARGVVLFTRAEDARRILQAAKRANLSQPFHW 306
               |.|.|:.:..:.    ||||.   ::.|.|..:.:.: |::|             |..|
  Rat   256 YYNEIVMSSTNVIIIYGETDSIIELSFRMWKSPVIQRIWI-TKSE-------------LDFP--- 303

  Fly   307 IASDGWGKQQKLLEGLEDIAEGAITVELQSEIIADF-----DRYMMQ------LTPETNQRNPWF 360
             .|:|        :...||..|.:|.......|:.|     .||.::      |.||.|..|
  Rat   304 -TSNG--------DLSHDIFYGTLTFLHHHGEISGFKNFVETRYHLKSRDLNLLIPEWNYFN--- 356

  Fly   361 AEYWEDTFNC-VLTSLSVKPDTSNSANS--TDNKIGVKAKTECDDSYRLSEKVGYEQESKTQFVV 422
              |.....|| :|.:.|     |||:..  |:.|.                ::.:..||.:  :.
  Rat   357 --YEASASNCKILRNYS-----SNSSLEWLTEQKF----------------QMAFNDESNS--IY 396

  Fly   423 DAVYAFAYALH--NLHN-DRCNTQSDQTTETRKHLQSESVWYRKISTDTKSQACPDMANYDGKEF 484
            :||||.|:|||  ||.. |....::.:.|.|.                     |..:
  Rat   397 NAVYAMAHALHEKNLQEVDNQEIKNGKRTSTH---------------------CLKL-------- 432

  Fly   485 YNNYLLNVSFIDLAGSEVKFDRQGDGLARYDILNYQRQENSSGYQYKV-IGKWF------NGLQL 542
             |::|....|.:..|.:|...::......|||::.  |..|...:.|| |||:.      ....|
  Rat   433 -NSFLRKTHFTNPLGDKVIMKQRERVQEDYDIVHI--QNFSQRLRIKVKIGKFSPYFPHGGRFHL 494

  Fly   543 NSETV-VWNKETEQPTSACSLPCEVGMIK--KQQGDTCCWICDSCE----SFEYVYDEFTCKDCG 600
            ..|.: :.....:.|:|.||..|..|..|  |:....||:||..|.    |.|...|:  |.:|.
  Rat   495 YEEMIELATGSRKMPSSVCSADCSPGFRKIWKEGMAACCFICSPCPENEISNETNMDQ--CVNCP 557

  Fly   601 PGLWPYADKLSCYALDIQYMKWNS----LFALIPMAIAIFGIALTSIVIVLFAKNHDTPLVRASG 661
            ...:...:|..|....:.::.:..    :.|||...:::|    |::|..:|.||||||:|:|:.
  Rat   558 EYQYANKEKNKCIQKGVIFLSYEDPLGMVLALIAFCLSVF----TAVVFCVFVKNHDTPIVKANN 618

  Fly   662 RELSYTLLFGILVCYCNTFALIAKPTIGSCVLQRFGIGVGFSIIYSALLTKTNRISRIFH--SAS 724
            |.|||.|:..::.|:..:|..|..|...:|:||:...|:.|::..|.:|.||..:...|.  ...
  Rat   619 RILSYLLVMSLMFCFLCSFFFIGHPNNATCILQQITFGITFTVAVSTVLAKTITVVLAFKITDPG 683

  Fly   725 KSAQRLKYISPQSQVVITTSLIAIQVLITMIWMVVEPPGTRFYYPDRR----EVILKC-KIQDMS 784
            :..:....:...:.::...||  :|.::..||:.|.||   |...|:.    .:|:.| |...|:
  Rat   684 RMLRNFLVLGAPNYIIPICSL--LQCILCAIWLAVSPP---FVDIDKHSEHGHIIIVCNKGSVMA 743

  Fly   785 FLFSQLYNMILITICTIYAIKTRKIPENFNESKFIGFTMYTTCIIWLAFVPIYFGTGNSYEVQTT 849
            |.....|...|.......|...:.:|:.|||:|::.|::.....:|:.|:|:|..|..  .|...
  Rat   744 FYCVLGYLACLALGSFTMAFLAKNLPDTFNEAKYLTFSILVFFSVWVTFLPVYHSTKG--RVMVA 806

  Fly   850 TLCISISLSASVALVCLYSPKVYILVFHPDKN 881
            ....||..|::..|.|:::||:||::..|::|
  Rat   807 VEIFSILSSSAGMLGCIFTPKIYIILVKPERN 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mGluR	NP_001259076.1	Periplasmic_Binding_Protein_Type_1	43..542	CDD:299141	111/518 (21%)
		ANF_receptor	72..518	CDD:279440	104/487 (21%)
		NCD3G	557..604	CDD:284890	17/52 (33%)
		7tm_3	638..873	CDD:278433	67/241 (28%)
Vom2r30	NP_001092937.1	Periplasmic_Binding_Protein_Type_1	38..500	CDD:299141	113/524 (22%)
		ANF_receptor	75..464	CDD:279440	103/486 (21%)
		NCD3G	510..561	CDD:284890	17/52 (33%)
		7tm_3	596..830	CDD:278433	68/244 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000